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  • Thomas F Patterson
Article

A murine model of Cryptococcus gattii meningoencephalitis

Thompson, G. R., Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R., Graybill, J. R. & Patterson, T. F., Jun 2012, In : Journal of Antimicrobial Chemotherapy. 67, 6, p. 1432-1438 7 p., dks060.

Research output: Contribution to journalArticle

20 Scopus citations

Animal models in mycology: What have we learned over the past 30 years

Kirkpatrick, W. R., Wiederhold, N. P., Najvar, L. K. & Patterson, T. F., Jan 1 2013, In : Current Fungal Infection Reports. 7, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antifungal therapy and length of hospitalization in transplant patients with invasive aspergillosis

Baddley, J. W., Andes, D. R., Marr, K. A., Kauffman, C. A., Kontoyiannis, D. P., Ito, J. I., Schuster, M. G., Brizendine, K. D., Patterson, T. F., Lyon, G. M., Boeckh, M., Oster, R. A., Chiller, T. & Pappas, P. G., Feb 2013, In : Medical mycology. 51, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Antifungal treatment affects the laboratory diagnosis of invasive aspergillosis

McCulloch, E., Ramage, G., Rajendran, R., Lappin, D. F., Jones, B., Warn, P., Shrief, R., Kirkpatrick, W. R., Patterson, T. F. & Williams, C., Jan 2012, In : Journal of Clinical Pathology. 65, 1, p. 83-86 4 p.

Research output: Contribution to journalArticle

36 Scopus citations
52 Scopus citations

A reference laboratory experience of clinically achievable voriconazole, posaconazole, and itraconazole concentrations withinthe bloodstream and cerebral spinal fluid

Wiederhold, N. P., Pennick, G. J., Dorsey, S. A., Furmaga, W., Lewis, J. S., Patterson, T. F., Sutton, D. A. & Fothergill, A. W., Jan 2014, In : Antimicrobial agents and chemotherapy. 58, 1, p. 424-431 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Aspergillus Polymerase Chain Reaction: Systematic Review of Evidence for Clinical Use in Comparison with Antigen Testing

White, P. L., Wingard, J. R., Bretagne, S., Löffler, J., Patterson, T. F., Slavin, M. A., Barnes, R. A., Pappas, P. G. & Donnelly, J. P., Oct 15 2015, In : Clinical Infectious Diseases. 61, 8, p. 1293-1303 11 p.

Research output: Contribution to journalArticle

96 Scopus citations

Assessment of aspergillus fumigatus in guinea pig bronchoalveolar lavages and pulmonary tissue by culture and realtime polymerase chain reaction studies

Hooper, D. G., Bolton, V. E., Sutton, J. S., Guilford, F. T., Straus, D. C., Najvar, L. K., Wiederhold, N. P., Kirkpatrick, W. R. & Patterson, T. F., Jan 2012, In : International journal of molecular sciences. 13, 1, p. 726-736 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Blastomyces helicus, a New Dimorphic Fungus Causing Fatal Pulmonary and Systemic Disease in Humans and Animals in Western Canada and the United States

Schwartz, I. S., Wiederhold, N. P., Hanson, K. E., Patterson, T. F. & Sigler, L., Jan 7 2019, In : Clinical Infectious Diseases. 68, 2, p. 188-196 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans

Wiederhold, N. P., Najvar, L. K., Bocanegra, R. A., Kirkpatrick, W. R. & Patterson, T. F., Jul 2011, In : Antimicrobial agents and chemotherapy. 55, 7, p. 3254-3260 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
10 Scopus citations

Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis

Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R. & Patterson, T. F., Feb 2012, In : Clinical Microbiology and Infection. 18, 2, p. E20-E23

Research output: Contribution to journalArticle

12 Scopus citations

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis

Thompson, G. R., Lewis, J. S., Nix, D. E. & Patterson, T. F., Feb 1 2019, In : Medical Mycology. 57, 1, p. S76-S84

Research output: Contribution to journalArticle

8 Scopus citations

Daptomycin-induced acute eosinophilic pneumonia: Analysis of the current data and illustrative case reports

Phillips, J., Cardile, A. P., Patterson, T. F. & Lewis, J. S., Oct 1 2013, In : Scandinavian Journal of Infectious Diseases. 45, 10, p. 804-808 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detection

Lengerova, M., Kocmanova, I., Racil, Z., Hrncirova, K., Pospisilova, S., Mayer, J., Najvar, L. K., Wiederhold, N. P., Kirkpatrick, W. R. & Patterson, T. F., Mar 1 2012, In : Journal of clinical microbiology. 50, 3, p. 602-608 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Detection of urinary excreted fungal galactomannan-like antigens for diagnosis of invasive aspergillosis

Dufresne, S. F., Datta, K., Li, X., Dadachova, E., Staab, J. F., Patterson, T. F., Feldmesser, M. & Marr, K. A., Aug 10 2012, In : PloS one. 7, 8, e42736.

Research output: Contribution to journalArticle

30 Scopus citations

Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing Aspergillosis

Lyon, G. M., Abdul-Ali, D., Loeffler, J., White, P. L., Wickes, B., Herrera, M. L., Alexander, B. D., Baden, L. R., Clancy, C., Denning, D., Nguyen, M. H., Sugrue, M., Wheat, L. J., Wingard, J. R., Donnelly, J. P., Barnes, R., Patterson, T. F. & Caliendo, A. M., Jul 2013, In : Journal of clinical microbiology. 51, 7, p. 2403-2405 3 p.

Research output: Contribution to journalArticle

19 Scopus citations
9 Scopus citations

Effect of antifungal treatment in a diet-based murine model of disseminated candidiasis acquired via the gastrointestinal tract

Kadosh, D., Najvar, L. K., Bocanegra, R., Olivo, M., Kirkpatrick, W. R., Wiederhold, N. & Patterson, T. F., Nov 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6703-6708 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Efficacy of delayed therapy with fosmanogepix (APX001) in a murine model of candida auris invasive candidiasis

Wiederhold, N. P., Najvar, L. K., Shaw, K. J., Jaramillo, R., Patterson, H., Olivo, M., Catano, G. & Patterson, T. F., 2019, In : Antimicrobial agents and chemotherapy. 63, 11, e01120-19.

Research output: Contribution to journalArticle

6 Scopus citations

Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis

Luo, G., Gebremariam, T., Lee, H., French, S. W., Wiederhold, N. P., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Jul 2013, In : Antimicrobial agents and chemotherapy. 57, 7, p. 3340-3347 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis

Wiederhold, N., Najvar, L. K., Matsumoto, S., Bocanegra, R. A., Herrera, M. L., Wickes, B. L., Kirkpatrick, W. R. & Patterson, T. F., May 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 5, p. 2875-2881 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Emergence of Azole Resistance in Aspergillus

Wiederhold, N. & Patterson, T. F., Oct 25 2015, In : Seminars in Respiratory and Critical Care Medicine. 36, 5, p. 673-680 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Emergomyces canadensis, a dimorphic fungus causing fatal systemic human disease in North America

Schwartz, I. S., Sanche, S., Wiederhold, N. P., Patterson, T. F. & Sigler, L., Apr 2018, In : Emerging Infectious Diseases. 24, 4, p. 758-761 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET)

Kauffman, C. A., Freifeld, A. G., Andes, D. R., Baddley, J. W., Herwaldt, L., Walker, R. C., Alexander, B. D., Anaissie, E. J., Benedict, K., Ito, J. I., Knapp, K. M., Lyon, G. M., Marr, K. A., Morrison, V. A., Park, B. J., Patterson, T. F., Schuster, M. G., Chiller, T. M. & Pappas, P. G., Apr 2014, In : Transplant Infectious Disease. 16, 2, p. 213-224 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: Results from an open-label trial

Vazquez, J., Reboli, A. C., Pappas, P. G., Patterson, T. F., Reinhardt, J., Chin-Hong, P., Tobin, E., Kett, D. H., Biswas, P. & Swanson, R., Feb 21 2014, In : BMC Infectious Diseases. 14, 1, 97.

Research output: Contribution to journalArticle

57 Scopus citations

Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus

Wiederhold, N. P., Najvar, L. K., Jaramillo, R., Olivo, M., Wickes, B. L., Catano, G. & Patterson, T. F., 2019, In : Antimicrobial agents and chemotherapy. 63, 10, e01165-19.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Fosmanogepix (APX001) is effective in the treatment of pulmonary murine mucormycosis due to rhizopus arrhizus

Gebremariam, T., Alkhazraji, S., Alqarihi, A., Wiederhold, N. P., Shaw, K. J., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Jun 2020, In : Antimicrobial agents and chemotherapy. 64, 6, e00178-20.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Fungal disease of the nose and paranasal sinuses

Thompson, G. R. & Patterson, T. F., Feb 2012, In : Journal of Allergy and Clinical Immunology. 129, 2, p. 321-326 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Fungal outbreak update from IDWeek

Slama, T., Kauffman, C. A., Patterson, T. F. & Neill, M. A., Feb 18 2013, In : Clinical Infectious Diseases. 56, 5, p. 621-624 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

Brumlik, M. J., Nkhoma, S., Kious, M. J., Thompson, G. R., Patterson, T. F., Siekierka, J. J., Anderson, T. J. C. & Curiel, T. J., Jun 2011, In : Experimental Parasitology. 128, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids

Mor, V., Rella, A., Farnou, A. M., Singh, A., Munshi, M., Bryan, A., Naseem, S., Konopka, J. B., Ojima, I., Bullesbach, E., Ashbaugh, A., Linke, M. J., Cushion, M., Collins, M., Ananthula, H. K., Sallans, L., Desai, P. B., Wiederhold, N. P., Fothergill, A. W., Kirkpatrick, W. R. & 15 others, Patterson, T., Wong, L. H., Sinha, S., Giaever, G., Nislow, C., Flaherty, P., Pan, X., Cesar, G. V., Tavares, P. D. M., Frases, S., Miranda, K., Rodrigues, M. L., Luberto, C., Nimrichter, L. & Poeta, M. D., Jun 23 2015, In : mBio. 6, 3, e00647-15.

Research output: Contribution to journalArticle

51 Scopus citations

Impact of unresolved neutropenia in patients with neutropenia and invasive aspergillosis: A post hoc analysis of the SECURE trial

Kontoyiannis, D. P., Selleslag, D., Mullane, K., Cornely, O. A., Hope, W., Lortholary, O., Croos-Dabrera, R., Lademacher, C., Engelhardt, M. & Patterson, T. F., Mar 1 2018, In : Journal of Antimicrobial Chemotherapy. 73, 3, p. 757-763 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Interlaboratory and interstudy reproducibility of a novel lateral- Flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis

Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R., Patterson, T. F. & Thornton, C. R., Feb 1 2013, In : Journal of clinical microbiology. 51, 2, p. 459-465 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
36 Scopus citations

Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Park, B. J., Pappas, P. G., Wannemuehler, K. A., Alexander, B. D., Anaissie, E. J., Andes, D. R., Baddley, J. W., Brown, J. M., Brumble, L. M., Freifeld, A. G., Hadley, S., Herwaldt, L., Ito, J. I., Kauffman, C. A., Lyon, G. M., Marr, K. A., Morrison, V. A., Papanicolaou, G., Patterson, T. F., Perl, T. M. & 5 others, Schuster, M. G., Walker, R., Wingard, J. R., Walsh, T. J. & Kontoyiannis, D. P., Oct 2011, In : Emerging Infectious Diseases. 17, 10, p. 1855-1864 10 p.

Research output: Contribution to journalArticle

156 Scopus citations

In vivo efficacy of VT-1129 against experimental cryptococcal meningitis with the use of a loading dose-maintenance dose administration strategy

Wiederhold, N. P., Xu, X., Wang, A., Najvar, L. K., Garvey, E. P., Ottinger, E. A., Alimardanov, A., Cradock, J., Behnke, M., Hoekstra, W. J., Brand, S. R., Schotzinger, R. J., Jaramillo, R., Olivo, M., Kirkpatrick, W. R. & Pattersona, T. F., Nov 2018, In : Antimicrobial agents and chemotherapy. 62, 11, e01315-18.

Research output: Contribution to journalArticle

6 Scopus citations

Isavuconazole is effective for the treatment of experimental cryptococcal meningitis

Wiederhold, N., Kovanda, L., Najvar, L. K., Bocanegra, R., Olivo, M., Kirkpatrick, W. R. & Patterson, T. F., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5600-5603 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): A phase 3, randomised-controlled, non-inferiority trial

Maertens, J. A., Raad, I. I., Marr, K. A., Patterson, T. F., Kontoyiannis, D. P., Cornely, O. A., Bow, E. J., Rahav, G., Neofytos, D., Aoun, M., Baddley, J. W., Giladi, M., Heinz, W. J., Herbrecht, R., Hope, W., Karthaus, M., Lee, D. G., Lortholary, O., Morrison, V. A., Oren, I. & 8 others, Selleslag, D., Shoham, S., Thompson, G. R., Lee, M., Maher, R. M., Schmitt-Hoffmann, A. H., Zeiher, B. & Ullmann, A. J., Feb 20 2016, In : The Lancet. 387, 10020, p. 760-769 10 p.

Research output: Contribution to journalArticle

340 Scopus citations

Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis

Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R., Sorrell, T. C. & Pattersona, T. F., Feb 1 2013, In : Antimicrobial agents and chemotherapy. 57, 2, p. 745-750 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Microbiology and epidemiology of oral yeast colonization in hemopoietic progenitor cell transplant recipients

Westbrook, S. D., Kirkpatrick, W. R., Wiederhold, N. P., Freytes, C. O., Toro, J. J., Patterson, T. F. & Redding, S. W., Mar 2013, In : Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 115, 3, p. 354-358 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection

Maincent, J. P., Najvar, L. K., Kirkpatrick, W. R., Huang, S., Patterson, T. F., Wiederhold, N., Peters, J. I. & Williams, R. O., Oct 5 2016, (Accepted/In press) In : Drug Development and Industrial Pharmacy. p. 1-11 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata

Wiederhold, N., Najvar, L. K., Jaramillo, R., Olivo, M., Pizzini, J., Catano, G. & Patterson, T. F., Feb 1 2018, In : The Journal of antimicrobial chemotherapy. 73, 2, p. 448-451 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Our 2014 approach to breakthrough invasive fungal infections

Maschmeyer, G. & Patterson, T. F., Nov 1 2014, In : Mycoses. 57, 11, p. 645-651 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Phaeohyphomycosis in transplant recipients: Results from the Transplant Associated Infection Surveillance Network (TRANSNET)

McCarty, T. P., Baddley, J. W., Walsh, T. J., Alexander, B. D., Kontoyiannis, D. P., Perl, T. M., Walker, R., Patterson, T. F., Schuster, M. G., Lyon, G. M., Wingard, J. R., Andes, D. R., Park, B. J., Brandt, M. E. & Pappas, P. G., 2015, In : Medical mycology. 53, 5, p. 440-446 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Prolyl endopeptidase activity in bronchoalveolar lavage fluid: A novel diagnostic biomarker in a guinea pig model of invasive pulmonary aspergillosis

Jambunathan, K., Watson, D. S., Najvar, L. K., Wiederhold, N. P., Kirkpatrick, W. R., Patterson, T. F., Askew, D. S., Kodukula, K. & Galande, A. K., Aug 2013, In : Medical mycology. 51, 6, p. 592-602 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis

Kirkpatrick, W. R., Najvar, L. K., Vallor, A. C., Wiederhold, N. P., Bocanegra, R., Pfeiffer, J., Perkins, K., Kugler, A. R., Sweeney, T. D. & Patterson, T. F., Apr 1 2012, In : Journal of Antimicrobial Chemotherapy. 67, 4, p. 970-976 7 p., dkr567.

Research output: Contribution to journalArticle

14 Scopus citations

Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection

Gebremariam, T., Alkhazraji, S., Lin, L., Wiederhold, N. P., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Sep 2017, In : Antimicrobial agents and chemotherapy. 61, 9, e00390-17.

Research output: Contribution to journalArticle

10 Scopus citations

Pulmonary aspergillosis: Recent advances

Thompson, G. R. & Patterson, T. F., Dec 21 2011, In : Seminars in Respiratory and Critical Care Medicine. 32, 6, p. 673-681 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

Lewis, J. S., Wiederhold, N. P., Wickes, B. L., Patterson, T. F. & Jorgensen, J. H., Sep 2013, In : Antimicrobial agents and chemotherapy. 57, 9, p. 4559-4561 3 p.

Research output: Contribution to journalArticle

60 Scopus citations