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  • Kumar Sharma
2020

Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue

Debnath, S., Lorenzo, C., Bansal, S., Morales, J., Rueda, R. O., Kasinath, B. S., Sharma, K., Sharma, K., O'connor, J. & O'connor, J., 2020, (Accepted/In press) In : American journal of nephrology.

Research output: Contribution to journalArticle

DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules

Zhang, G., Zhang, J., DeHoog, R. J., Pennathur, S., Anderton, C. R., Venkatachalam, M. A., Alexandrov, T., Eberlin, L. S. & Sharma, K., Jan 1 2020, In : Metabolomics. 16, 1, 11.

Research output: Contribution to journalArticle

1 Scopus citations

Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease

Afshinnia, F., Zeng, L., Byun, J., Wernisch, S., Deo, R., Chen, J., Hamm, L., Miller, E. R., Rhee, E. P., Fischer, M. J., Sharma, K., Feldman, H. I., Michailidis, G. & Pennathur, S., 2020, In : Nephrology Dialysis Transplantation. 35, 2, p. 303-312 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes

Concepcion, J., Concepcion, J., Chen, K., Saito, R., Gangoiti, J., Mendez, E., Nikita, M. E., Barshop, B. A., Barshop, B. A., Natarajan, L., Sharma, K., Kim, J. J. & Kim, J. J., Jun 2020, In : PloS one. 15, 6 June, e0234970.

Research output: Contribution to journalArticle

Open Access

mGWAS: next generation genetic prediction in kidney disease

Montemayor, D. & Sharma, K., May 1 2020, In : Nature Reviews Nephrology. 16, 5, p. 255-256 2 p.

Research output: Contribution to journalArticle

Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity

Nemani, N., Dong, Z., Daw, C. C., Madaris, T. R., Ramachandran, K., Enslow, B. T., Rubannelsonkumar, C. S., Shanmughapriya, S., Mallireddigari, V., Maity, S., SinghMalla, P., Natarajanseenivasan, K., Hooper, R., Shannon, C. E., Tourtellotte, W. G., Singh, B. B., Reeves, W. B., Sharma, K., Norton, L., Srikantan, S. & 2 others, Soboloff, J. & Madesh, M., Apr 21 2020, In : Science signaling. 13, 628

Research output: Contribution to journalArticle

1 Scopus citations

Nephrology Training: Time to Revisit Integrative Physiology

Bansal, S., Kanakia, R., Sharma, K., Tsai, S. & Prasad, A., Mar 1 2020, In : American journal of nephrology. 51, 3, p. 244-248 5 p.

Research output: Contribution to journalEditorial

Predictive Biomarkers in Nephrology Around the Corner

Perco, P. & Sharma, K., Jan 2020, In : Kidney International Reports. 5, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

Open Access

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

Miyamoto, S., Zhang, G., Hall, D., Oates, P. J., Maity, S., Madesh, M., Han, X. & Sharma, K., May 22 2020, In : Journal of Biological Chemistry. 295, 21, p. 7249-7260 12 p.

Research output: Contribution to journalArticle

2019

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice

Declèves, A. E., Mathew, A. V., Armando, A. M., Han, X., Dennis, E. A., Quehenberger, O. & Sharma, K., 2019, In : Journal of lipid research. 60, 5, p. 937-952 16 p.

Research output: Contribution to journalArticle

Association of Urinary Oxalate Excretion with the Risk of Chronic Kidney Disease Progression

for the Chronic Renal Insufficiency Cohort study investigators, Apr 2019, In : JAMA internal medicine. 179, 4, p. 542-551 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Differential network enrichment analysis reveals novel lipid pathways in chronic kidney disease

Ma, J., Karnovsky, A., Afshinnia, F., Wigginton, J., Rader, D. J., Natarajan, L., Sharma, K., Porter, A. C., Rahman, M., He, J., Hamm, L., Shafi, T., Gipson, D., Gadegbeku, C., Feldman, H., Michailidis, G., Pennathur, S. & Wren, J., Sep 15 2019, In : Bioinformatics. 35, 18, p. 3441-3452 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Effect of renal tubule-specific knockdown of the Na+/h+ exchanger NHE3 in akita diabetic mice

Onishi, A., Fu, Y., Darshi, M., Crespo-Masip, M., Huang, W., Song, P., Patel, R., Kim, Y. C., Nespoux, J., Freeman, B., Soleimani, M., Thomson, S., Sharma, K. & Vallon, V., Aug 2019, In : American Journal of Physiology - Renal Physiology. 317, 2, p. F419-F434

Research output: Contribution to journalArticle

11 Scopus citations

Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes

Mulder, S., Heerspink, H. J. L., Darshi, M., Kim, J. J., Laverman, G. D., Sharma, K. & Pena, M. J., Nov 1 2019, In : Diabetes, Obesity and Metabolism. 21, 11, p. 2422-2428 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis

Øvrehus, M. A., Bruheim, P., Ju, W., Zelnick, L. R., Langlo, K. A., Sharma, K., de Boer, I. H. & Hallan, S. I., Feb 2019, In : Kidney International Reports. 4, 2, p. 321-333 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Global Health Training Opportunities in North American Nephrology Fellowships

International Society of Nephrology North American and Caribbean Regional Board, Jul 2019, In : Kidney International Reports. 4, 7, p. 904-907 4 p.

Research output: Contribution to journalEditorial

Open Access

Increased lipogenesis and impaired B-oxidation predict type 2 diabetic kidney disease progression in American Indians

Afshinnia, F., Nair, V., Lin, J., Rajendiran, T. M., Soni, T., Byun, J., Sharma, K., Fort, P. E., Gardner, T. W., Looker, H. C., Nelson, R. G., Brosius, F. C., Feldman, E. L., Michailidis, G., Kretzler, M. & Pennathur, S., Nov 1 2019, In : JCI Insight. 4, 21, e130317.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Management of calciphylaxis in a burn center: A case series and review of the literature

Dado, D. N., Huang, B., Foster, D. V., Nielsen, J. S., Gurney, J. M., Morrow, B. D., Sharma, K., Chung, K. K. & Ainsworth, C. R., Feb 2019, In : Burns. 45, 1, p. 241-246 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular imaging of the glomerulus via mesangial cell uptake of radiolabeled tilmanocept

Qin, Z., Hoh, C. K., Olson, E. S., Jahromi, A. H., Hall, D. J., Barback, C. V., You, Y. H., Yanagita, M., Sharma, K. & Vera, D. R., Jan 1 2019, In : Journal of Nuclear Medicine. 60, 9, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Myofibroblasts acquire retinoic acid–producing ability during fibroblast-to-myofibroblast transition following kidney injury

Nakamura, J., Sato, Y., Kitai, Y., Wajima, S., Yamamoto, S., Oguchi, A., Yamada, R., Kaneko, K., Kondo, M., Uchino, E., Tsuchida, J., Hirano, K., Sharma, K., Kohno, K. & Yanagita, M., Mar 2019, In : Kidney international. 95, 3, p. 526-539 14 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Role of mitochondria in the regulation of kidney function and metabolism in type 2 diabetes

Han, X., Shi, Y., Diamond-Stanic, M. & Sharma, K., Jan 1 2019, Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases. Elsevier, p. 287-300 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sex-related disparities in CKD progression

CRIC Investigators, Jan 1 2019, In : Journal of the American Society of Nephrology. 30, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

The NASA twins study: A multidimensional analysis of a year-long human spaceflight

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A. & 62 others, Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. & Turek, F. W., 2019, In : Science. 364, 6436, eaau8650.

Research output: Contribution to journalArticle

91 Scopus citations
2018

A new drug combination significantly reduces kidney tumor progression in kidney mouse model

Liang, S., Cuellar, T., Nowacki, M., Nayak, B. K., Dong, L., Li, B., Sharma, K. & Habib, S. L., Aug 31 2018, In : Oncotarget. 9, 68, p. 32900-32916 17 p.

Research output: Contribution to journalArticle

Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial

de Zeeuw, D., Renfurm, R. W., Bakris, G., Rossing, P., Perkovic, V., Hou, F. F., Nangaku, M., Sharma, K., Heerspink, H. J. L., Garcia-Hernandez, A. & Larsson, T. E., Dec 1 2018, In : The lancet. Diabetes & endocrinology. 6, 12, p. 925-933 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Introduction: Systems Biology of Kidney Disease

Sharma, K., Susztak, K. & Pennathur, S., Mar 1 2018, In : Seminars in Nephrology. 38, 2, p. 99-100 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

The Warburg Effect in Diabetic Kidney Disease

Zhang, G., Darshi, M. & Sharma, K., Mar 2018, In : Seminars in nephrology. 38, 2, p. 111-120 10 p.

Research output: Contribution to journalReview article

19 Scopus citations

Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies

Sharma, K. & Paša-Tolić, L., Jun 1 2018, In : Kidney International. 93, 6, p. 1265-1267 3 p.

Research output: Contribution to journalComment/debate

Urine metabolites are associated with glomerular lesions in type 2 diabetes

Saulnier, P. J., Darshi, M., Wheelock, K. M., Looker, H. C., Fufaa, G. D., Knowler, W. C., Weil, E. J., Tanamas, S. K., Lemley, K. V., Saito, R., Natarajan, L., Nelson, R. G. & Sharma, K., Jun 1 2018, In : Metabolomics. 14, 6, 84.

Research output: Contribution to journalArticle

3 Scopus citations

Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus

Yamamoto, C. M., Murakami, T., Oakes, M. L., Mitsuhashi, M., Kelly, C., Henry, R. R. & Sharma, K., Jun 1 2018, In : American Journal of Nephrology. 47, 5, p. 283-291 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Acid Load and Phosphorus Homeostasis in CKD

Chronic Renal Insufficiency Cohort (CRIC) Study Investigators & Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Oct 2017, In : American Journal of Kidney Diseases. 70, 4, p. 541-550 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin

Börgeson, E., Wallenius, V., Syed, G. H., Darshi, M., Lantero Rodriguez, J., Biörserud, C., Ragnmark Ek, M., Björklund, P., Quiding-Järbrink, M., Fändriks, L., Godson, C. & Sharma, K., Apr 1 2017, In : Diabetologia. 60, 4, p. 729-739 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression

Zhang, G., Saito, R. & Sharma, K., Jun 2017, In : Kidney international. 91, 6, p. 1274-1276 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Kidney disease and obesity: Epidemiology, mechanisms and treatment

Câmara, N. O. S., Iseki, K., Kramer, H., Liu, Z. H. & Sharma, K., Mar 1 2017, In : Nature Reviews Nephrology. 13, 3, p. 181-190 10 p.

Research output: Contribution to journalReview article

37 Scopus citations

Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-T2D trial

Groop, P. H., Cooper, M. E., Perkovic, V., Hocher, B., Kanasaki, K., Haneda, M., Schernthaner, G., Sharma, K., Stanton, R. C., Toto, R., Cescutti, J., Gordat, M., Meinicke, T., Koitka-Weber, A., Thiemann, S. & von Eynatten, M., Nov 2017, In : Diabetes, Obesity and Metabolism. 19, 11, p. 1610-1619 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Hallan, S., Afkarian, M., Zelnick, L. R., Kestenbaum, B., Sharma, S., Saito, R., Darshi, M., Barding, G., Raftery, D., Ju, W., Kretzler, M., Sharma, K. & de Boer, I. H., Dec 2017, In : EBioMedicine. 26, p. 68-77 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mitochondrial dysfunction in the diabetic kidney

Sharma, K., May 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 553-562 10 p. (Advances in Experimental Medicine and Biology; vol. 982).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations
1 Scopus citations

The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathy

Pena, M. J., de Zeeuw, D., Andress, D., Brennan, J. J., Correa-Rotter, R., Coll, B., Kohan, D. E., Makino, H., Perkovic, V., Remuzzi, G., Tobe, S. W., Toto, R., Parving, H. H., Sharma, S., Corringham, T., Sharma, K. & Heerspink, H. J. L., May 2017, In : Diabetes, Obesity and Metabolism. 19, 5, p. 749-753 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice

Kim, I. H., Xu, J., Liu, X., Koyama, Y., Ma, H. Y., Diggle, K., You, Y. H., Schilling, J. M., Jeste, D., Sharma, K., Brenner, D. A. & Kisseleva, T., Aug 1 2016, In : AGE. 38, 4, p. 291-302 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease

Coughlan, M. T. & Sharma, K., Aug 1 2016, In : Kidney international. 90, 2, p. 272-279 8 p.

Research output: Contribution to journalReview article

35 Scopus citations

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., Shimizu, A., Narumiya, S., Kaisho, T., Arita, M., Yanagisawa, M., Miyasaka, M., Sharma, K., Minato, N., Kawamoto, H. & Yanagita, M., Jan 1 2016, In : JCI Insight. 1, 11, e87680.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Anders, H. J., Rovin, B., Jayne, D., Brunetta, P., Coppo, R., Davidson, A., Devarapu, S. K., de Zeeuw, D., Duffield, J., Eulberg, D., Fierro, A., Floege, J., Frese, S., Guillevin, L., Holdsworth, S., Hughes, J., Kettritz, R., Kluger, M., Krebs, C., Lapteva, L. & 25 others, Levin, A., Li, J., Lightstone, L., Mack, M., Mansouri, L., McAdoo, S., McKinney, E., Panzer, U., Parikh, S., Pusey, C., Putterman, C., Rabelink, T., Radbruch, A., Rees, A., Reilly, M., Reinders, M., Remuzzi, G., Ruggenenti, P., Sacks, S., Schall, T. J., Meyer-Schwesinger, C., Sharma, K., Suzuki, Y., Tomas, N. M. & Zhao, M. H., 2016, In : Kidney International Reports. 1, 4, p. 327-339 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Management of patients with diabetes and CKD: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Perkovic, V., Agarwal, R., Fioretto, P., Hemmelgarn, B. R., Levin, A., Thomas, M. C., Wanner, C., Kasiske, B. L., Wheeler, D. C., Groop, P. H., Bakris, G. L., Cooper, M. E., Chae, D. W., Davidson, M. H., de Boer, I. H., de Zeeuw, D., Fornoni, A., Gnudi, L., Herzog, C. A., Hung, A. M. & 30 others, Jafar, T. H., Jardine, M., Jha, V., Ji, L., Kahn, S. E., Langham, R. G., Lerma, E. V., Ma, R. C. W., Makino, H., Marre, M., Mauer, M., Metsärinne, K., Nelson, R. G., Pecoits-Filho, R., Pollock, C. A., Rajapurkar, M., Rossing, P., Rychlík, I., Sharma, K., Stanton, R. C., Tesař, V., Tikkanen, I., Tomson, C. R. V., Toto, R. D., Tsukamoto, Y., Tuttle, K. R., Wada, T., Williams, W. W., Zhang, H. & Zoungas, S., Dec 1 2016, In : Kidney international. 90, 6, p. 1175-1183 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

Miyamoto, S., Hsu, C. C., Hamm, G., Darshi, M., Diamond-Stanic, M., Declèves, A. E., Slater, L., Pennathur, S., Stauber, J., Dorrestein, P. C. & Sharma, K., May 1 2016, In : EBioMedicine. 7, p. 121-134 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer

Darshi, M., Van Espen, B. & Sharma, K., Sep 1 2016, In : American journal of nephrology. 44, 2, p. 92-103 12 p.

Research output: Contribution to journalReview article

21 Scopus citations

Metabolomics reveals a key role for fumarate in mediating the effects of NADPH oxidase 4 in diabetic kidney disease

You, Y. H., Quach, T., Saito, R., Pham, J. & Sharma, K., Feb 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 466-481 16 p.

Research output: Contribution to journalArticle

80 Scopus citations