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  • Sudha Seshadri
2020

Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies

Ding, J., Davis-Plourde, K. L., Sedaghat, S., Tully, P. J., Wang, W., Phillips, C., Pase, M. P., Himali, J. J., Gwen Windham, B., Griswold, M., Gottesman, R., Mosley, T. H., White, L., Guðnason, V., Debette, S., Beiser, A. S., Seshadri, S., Ikram, M. A., Meirelles, O., Tzourio, C. & 1 others, Launer, L. J., Jan 2020, In : The Lancet Neurology. 19, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Are large simple trials for dementia prevention possible?

Whiteley, W. N., Anand, S., Bangdiwala, S. I., Bosch, J., Canavan, M., Chertkow, H., Gerstein, H. C., Gorelick, P., O'Donnell, M., Paré, G., Pigeyre, M., Seshadri, S., Sharma, M., Smith, E. E., Williamson, J., Cukierman-Yaffe, T., Hart, R. G. & Yusuf, S., Feb 27 2020, In : Age and ageing. 49, 2, p. 154-160 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage among Participants in the Framingham Heart Study between 1948 and 2016

Lioutas, V. A., Beiser, A. S., Aparicio, H. J., Himali, J. J., Selim, M. H., Romero, J. R. & Seshadri, S., 2020, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease: A Systematic Review and Meta-Analysis

the Variability in Blood Pressure and Brain Health Consortium, Jan 7 2020, In : Journal of the American Heart Association. 9, 1, e013841.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia

Lee, C. M. Y., Woodward, M., Batty, G. D., Beiser, A. S., Bell, S., Berr, C., Bjertness, E., Chalmers, J., Clarke, R., Dartigues, J. F., Davis-Plourde, K., Debette, S., Di Angelantonio, E., Feart, C., Frikke-Schmidt, R., Gregson, J., Haan, M. N., Hassing, L. B., Hayden, K. M., Hoevenaar-Blom, M. P. & 26 others, Kaprio, J., Kivimaki, M., Lappas, G., Larson, E. B., LeBlanc, E. S., Lee, A., Lui, L. Y., Moll van Charante, E. P., Ninomiya, T., Nordestgaard, L. T., Ohara, T., Ohkuma, T., Palviainen, T., Peres, K., Peters, R., Qizilbash, N., Richard, E., Rosengren, A., Seshadri, S., Shipley, M., Singh-Manoux, A., Strand, B. H., van Gool, W. A., Vuoksimaa, E., Yaffe, K. & Huxley, R. R., Apr 1 2020, In : Obesity Reviews. 21, 4, e12989.

Research output: Contribution to journalReview article

Open Access

Association of CD14 with incident dementia and markers of brain aging and injury

Pase, M. P., Himali, J. J., Beiser, A. S., DeCarli, C., McGrath, E. R., Satizabal, C. L., Aparicio, H. J., Adams, H. H. H., Reiner, A. P., Longstreth, W. T., Fornage, M., Tracy, R. P., Lopez, O., Psaty, B. M., Levy, D., Seshadri, S. & Bis, J. C., Jan 21 2020, In : Neurology. 94, 3, p. e254-e266

Research output: Contribution to journalArticle

1 Scopus citations

Circulating ceramide ratios and risk of vascular brain aging and dementia

McGrath, E. R., Himali, J. J., Xanthakis, V., Duncan, M. S., Schaffer, J. E., Ory, D. S., Peterson, L. R., DeCarli, C., Pase, M. P., Satizabal, C. L., Vasan, R. S., Beiser, A. S. & Seshadri, S., Feb 1 2020, In : Annals of Clinical and Translational Neurology. 7, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

Parker, N., Vidal-Pineiro, D., French, L., Shin, J., Adams, H. H. H., Brodaty, H., Cox, S. R., Deary, I. J., Fjell, A. M., Frenzel, S., Grabe, H., Hosten, N., Ikram, M. A., Jiang, J., Knol, M. J., Mazoyer, B., Mishra, A., Sachdev, P. S., Salum, G., Satizabal, C. L. & 12 others, Schmidt, H., Schmidt, R., Seshadri, S., Schumann, G., Völzke, H., Walhovd, K. B., Wen, W., Wittfeld, K., Yang, Q., Debette, S., Pausova, Z. & Paus, T., Mar 21 2020, In : Cerebral cortex (New York, N.Y. : 1991). 30, 2, p. 575-586 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes

Enigma Consortium & neuroCHARGE Working Group, Jun 1 2020, In : Cerebral cortex (New York, N.Y. : 1991). 30, 7, p. 4121-4139 19 p.

Research output: Contribution to journalArticle

Joint trajectories of cognition and gait speed in Mexican American and European American older adults: The San Antonio longitudinal study of aging

Gonzales, M. M., Wang, C. P., Quiben, M., MacCarthy, D., Seshadri, S., Jacob, M. & Hazuda, H., Aug 1 2020, In : International journal of geriatric psychiatry. 35, 8, p. 897-906 10 p.

Research output: Contribution to journalArticle

Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study

Romero, J. R., Demissie, S., Beiser, A., Himali, J. J., DeCarli, C., Levy, D. & Seshadri, S., Jul 1 2020, In : Annals of Clinical and Translational Neurology. 7, 7, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Open Access

The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group, Mar 20 2020, In : Science. 367, 6484, aay6690.

Research output: Contribution to journalArticle

25 Scopus citations

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Alzheimer’s Disease Sequencing Project, Aug 1 2020, In : Molecular psychiatry. 25, 8, p. 1859-1875 17 p.

Research output: Contribution to journalArticle

38 Scopus citations
2019

Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study

Spartano, N. L., Demissie, S., Himali, J. J., Dukes, K. A., Murabito, J. M., Vasan, R. S., Beiser, A. S. & Seshadri, S., 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 618-626 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

van der Lee, S. J., Knol, M. J., Chauhan, G., Satizabal, C. L., Smith, A. V., Hofer, E., Bis, J. C., Hibar, D. P., Hilal, S., van den Akker, E. B., Arfanakis, K., Bernard, M., Yanek, L. R., Amin, N., Crivello, F., Cheung, J. W., Harris, T. B., Saba, Y., Lopez, O. L., Li, S. & 42 others, van der Grond, J., Yu, L., Paus, T., Roshchupkin, G. V., Amouyel, P., Jahanshad, N., Taylor, K. D., Yang, Q., Mathias, R. A., Boehringer, S., Mazoyer, B., Rice, K., Cheng, C. Y., Maillard, P., van Heemst, D., Wong, T. Y., Niessen, W. J., Beiser, A. S., Beekman, M., Zhao, W., Nyquist, P. A., Chen, C., Launer, L. J., Psaty, B. M., Ikram, M. K., Vernooij, M. W., Schmidt, H., Pausova, Z., Becker, D. M., De Jager, P. L., Thompson, P. M., van Duijn, C. M., Bennett, D. A., Slagboom, P. E., Schmidt, R., Longstreth, W. T., Ikram, M. A., Seshadri, S., Debette, S., Gudnason, V., Adams, H. H. H. & DeCarli, C., Dec 1 2019, In : Communications Biology. 2, 1, 285.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology

INVENT Consortium, MEGASTROKE Consortium of the International Stroke Genetics Consortium, 2019, In : Blood. 133, 9, p. 967-977 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Ma, Y., Jun, G. R., Zhang, X., Chung, J., Naj, A. C., Chen, Y., Bellenguez, C., Hamilton-Nelson, K., Martin, E. R., Kunkle, B. W., Bis, J. C., Debette, S., Destefano, A. L., Fornage, M., Nicolas, G., Van Duijn, C., Bennett, D. A., De Jager, P. L., Mayeux, R., Haines, J. L. & 6 others, Pericak-Vance, M. A., Seshadri, S., Lambert, J. C., Schellenberg, G. D., Lunetta, K. L. & Farrer, L. A., Sep 2019, In : JAMA Neurology. 76, 9, p. 1099-1108 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

Alzheimer's Disease Sequencing Project, Mar 2019, In : Alzheimer's and Dementia. 15, 3, p. 441-452 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes

Pase, M. P., Beiser, A. S., Himali, J. J., Satizabal, C. L., Aparicio, H. J., Decarli, C., Chêne, G., Dufouil, C. & Seshadri, S., Jan 1 2019, In : JAMA Neurology.

Research output: Contribution to journalArticle

21 Scopus citations

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study

Spartano, N. L., Davis-Plourde, K. L., Himali, J. J., Andersson, C., Pase, M. P., Maillard, P., DeCarli, C., Murabito, J. M., Beiser, A. S., Vasan, R. S. & Seshadri, S., Apr 5 2019, In : JAMA network open. 2, 4, p. e192745

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts

Weinstein, G., Davis-Plourde, K. L., Conner, S., Himali, J. J., Beiser, A. S., Lee, A., Rawlings, A. M., Sedaghat, S., Ding, J., Moshier, E., Van Duijn, C. M., Beeri, M. S., Selvin, E., Arfan Ikram, M., Launer, L. J., Haan, M. N. & Seshadri, S., Feb 2019, In : PloS one. 14, 2, e0212293.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

Mishra, A., Chauhan, G., Violleau, M. H., Vojinovic, D., Jian, X., Bis, J. C., Li, S., Saba, Y., Grenier-Boley, B., Yang, Q., Bartz, T. M., Hofer, E., Soumaré, A., Peng, F., Duperron, M. G., Foglio, M., Mosley, T. H., Schmidt, R., Psaty, B. M., Launer, L. J. & 14 others, Boerwinkle, E., Zhu, Y., Mazoyer, B., Lathrop, M., Bellenguez, C., Van Duijn, C. M., Arfan Ikram, M., Schmidt, H., Longstreth, W. T., Fornage, M., Seshadri, S., Joutel, A., Tzourio, C. & Debette, S., Jan 1 2019, In : Brain. 142, 4, p. 1009-1023 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Sep 1 2019, In : Nature Genetics. 51, 9, p. 1423-1424 2 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., DeRosse, P., Djurovic, S. & 202 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., van der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Lill, C. M., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, R., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., Dec 1 2019, In : Nature communications. 10, 1, 2068.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Author response: Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham study

Weinstein, G., Davis-Plourde, K. L., Beiser, A. S. & Seshadri, S., 2019, (Accepted/In press) In : Liver International.

Research output: Contribution to journalLetter

Author response: Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study

Echouffo-Tcheugui, J., Conner, S. C., Himali, J. J., Beiser, A. S. & Seshadri, S., Oct 8 2019, In : Neurology. 93, 15, p. 685-686 2 p.

Research output: Contribution to journalArticle

Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study

McGrath, E. R., Himali, J. J., Levy, D., Conner, S. C., Pase, M. P., Abraham, C. R., Courchesne, P., Satizabal, C. L., Vasan, R. S., Beiser, A. S. & Seshadri, S., Mar 2019, In : PloS one. 14, 3, e0213321.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Circulating IGFBP-2: a novel biomarker for incident dementia

McGrath, E. R., Himali, J. J., Levy, D., Conner, S. C., DeCarli, C. S., Pase, M. P., Courchesne, P., Satizabal, C. L., Vasan, R. S., Beiser, A. S. & Seshadri, S., Sep 1 2019, In : Annals of Clinical and Translational Neurology. 6, 9, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Circulating monocyte chemoattractant protein-1 and risk of stroke meta-analysis of population-based studies involving 17180 individuals

Georgakis, M. K., Malik, R., Björkbacka, H., Pana, T. A., Demissie, S., Ayers, C., Elhadad, M. A., Fornage, M., Beiser, A. S., Benjamin, E. J., Matthijs Boekholdt, S., Engström, G., Herder, C., Hoogeveen, R. C., Koenig, W., Melander, O., Orho-Melander, M., Schiopu, A., Söderholm, M., Wareham, N. & 7 others, Ballantyne, C. M., Peters, A., Seshadri, S., Myint, P. K., Nilsson, J., De Lemos, J. A. & Dichgans, M., Sep 27 2019, In : Circulation research. 125, 8, p. 773-782 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis

Yakushiji, Y., Wilson, D., Ambler, G., Charidimou, A., Beiser, A., Van Buchem, M. A., Decarli, C., Ding, D., Gudnason, V., Hara, H., Imaizumi, T., Kohara, K., Kwon, H. M., Launer, L. J., Mok, V., Phan, T., Preis, S. R., Romero, J. R., Seshadri, S., Srikanth, V. & 7 others, Takashima, Y., Tsushima, Y., Wang, Z., Wolf, P. A., Xiong, Y., Yamaguchi, S. & Werring, D. J., Mar 5 2019, In : Neurology. 92, 10, p. E1086-E1097

Research output: Contribution to journalArticle

10 Scopus citations

Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings

Adams, H. H. H., Roshchupkin, G. V., DeCarli, C., Franke, B., Grabe, H. J., Habes, M., Jahanshad, N., Medland, S. E., Niessen, W., Satizabal, C. L., Schmidt, R., Seshadri, S., Teumer, A., Thompson, P. M., Vernooij, M. W., Wittfeld, K. & Ikram, M. A., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 286-290 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease

Baker, E., Sims, R., Leonenko, G., Frizzati, A., Harwood, J. C., Grozeva, D., Morgan, K., Passmore, P., Holmes, C., Powell, J., Brayne, C., Gill, M., Mead, S., Bossù, P., Spalletta, G., Goate, A. M., Cruchaga, C., Maier, W., Heun, R., Jessen, F. & 16 others, Peters, O., Dichgans, M., FröLich, L., Ramirez, A., Jones, L., Hardy, J., Ivanov, D., Hill, M., Holmans, P., Allen, N. D., Morgan, B. P., Seshadri, S., Schellenberg, G. D., Amouyel, P., Williams, J. & Escott-Price, V., 2019, In : PloS one. 14, 7, e0218111.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer’s Disease Genetics Consortium (ADGC) & Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Jan 29 2019, In : Neurology. 92, 5, p. E486-E503

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 others, Li, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C. Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B. C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J. J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., van Tol, M. J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J. L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., Nov 1 2019, In : Nature Genetics. 51, 11, p. 1624-1636 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

167 Scopus citations

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment

Nagtegaal, A. P., Broer, L., Zilhao, N. R., Jakobsdottir, J., Bishop, C. E., Brumat, M., Christiansen, M. W., Cocca, M., Gao, Y., Heard-Costa, N. L., Evans, D. S., Pankratz, N., Pratt, S. R., Price, T. R., Spankovich, C., Stimson, M. R., Valle, K., Vuckovic, D., Wells, H., Eiriksdottir, G. & 22 others, Fransen, E., Ikram, M. A., Li, C. M., Longstreth, W. T., Steves, C., Van Camp, G., Correa, A., Cruickshanks, K. J., Gasparini, P., Girotto, G., Kaplan, R. C., Nalls, M., Schweinfurth, J. M., Seshadri, S., Sotoodehnia, N., Tranah, G. J., Uitterlinden, A. G., Wilson, J. G., Gudnason, V., Hoffman, H. J., Williams, F. M. K. & Goedegebure, A., Dec 1 2019, In : Scientific reports. 9, 1, 15192.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Smith, E. E., Biessels, G. J., De Guio, F., de Leeuw, F. E., Duchesne, S., Düring, M., Frayne, R., Ikram, M. A., Jouvent, E., MacIntosh, B. J., Thrippleton, M. J., Vernooij, M. W., Adams, H., Backes, W. H., Ballerini, L., Black, S. E., Chen, C., Corriveau, R., DeCarli, C., Greenberg, S. M. & 29 others, Gurol, M. E., Ingrisch, M., Job, D., Lam, B. Y. K., Launer, L. J., Linn, J., McCreary, C. R., Mok, V. C. T., Pantoni, L., Pike, G. B., Ramirez, J., Reijmer, Y. D., Romero, J. R., Ropele, S., Rost, N. S., Sachdev, P. S., Scott, C. J. M., Seshadri, S., Sharma, M., Sourbron, S., Steketee, R. M. E., Swartz, R. H., van Oostenbrugge, R., van Osch, M., van Rooden, S., Viswanathan, A., Werring, D., Dichgans, M. & Wardlaw, J. M., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 191-204 14 p.

Research output: Contribution to journalShort survey

Open Access
11 Scopus citations

Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes

Vasan, R. S., Short, M. I., Niiranen, T. J., Xanthakis, V., DeCarli, C., Cheng, S., Seshadri, S. & Mitchell, G. F., Jul 16 2019, In : Journal of the American Heart Association. 8, 14, p. e012141

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts

Conner, S. C., Benayoun, L., Himali, J. J., Adams, S. L., Yang, Q., DeCarli, C., Blusztajn, J. K., Beiser, A., Seshadri, S. & Delalle, I., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 357-365 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mid-life and late-life vascular risk factor burden and neuropathology in old age

Conner, S. C., Pase, M. P., Carneiro, H., Raman, M. R., McKee, A. C., Alvarez, V. E., Walker, J. M., Satizabal, C. L., Himali, J. J., Stein, T. D., Beiser, A. & Seshadri, S., Dec 1 2019, In : Annals of Clinical and Translational Neurology. 6, 12, p. 2403-2412 10 p.

Research output: Contribution to journalArticle

Open Access

Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study

Weinstein, G., Davis-Plourde, K., Himali, J. J., Zelber-Sagi, S., Beiser, A. S. & Seshadri, S., Sep 1 2019, In : Liver International. 39, 9, p. 1713-1721 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10–pulmonary function association

Xu, J., Gaddis, N. C., Bartz, T. M., Hou, R., Manichaikul, A. W., Pankratz, N., Smith, A. V., Sun, F., Terzikhan, N., Markunas, C. A., Patchen, B. K., Schu, M., Beydoun, M. A., Brusselle, G. G., Eiriksdottir, G., Zhou, X., Wood, A. C., Graff, M., Harris, T. B., Arfan Ikram, M. & 30 others, Jacobs, D. R., Launer, L. J., Lemaitre, R. N., O’Connor, G. T., Oelsner, E. C., Psaty, B. M., Vasan, R. S., Rohde, R. R., Rich, S. S., Rotter, J. I., Seshadri, S., Smith, L. J., Tiemeier, H., Tsai, M. Y., Uitterlinden, A. G., Saroja Voruganti, V., Xu, H., Zilhão, N. R., Fornage, M., Carola Zillikens, M., London, S. J., Graham Barr, R., Dupuis, J., Gharib, S. A., Gudnason, V., Lahousse, L., North, K. E., Steffen, L. M., Cassano, P. A. & Hancock, D. B., Mar 1 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 5, p. 631-642 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Schmidt, A. F., Holmes, M. V., Preiss, D., Swerdlow, D. I., Denaxas, S., Fatemifar, G., Faraway, R., Finan, C., Valentine, D., Fairhurst-Hunter, Z., Hartwig, F. P., Horta, B. L., Hypponen, E., Power, C., Moldovan, M., Van Iperen, E., Hovingh, K., Demuth, I., Norman, K., Steinhagen-Thiessen, E. & 145 others, Demuth, J., Bertram, L., Lill, C. M., Coassin, S., Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., Van Der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R. A., Luan, JA., Bobak, M., Malyutina, S., Pajak, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Jess, T., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Lester, K. H., Larson, E. B., Crosslin, D. R., De Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., Scott, R., Schofield, P., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., Van Der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Meade, T., Christophersen, I. E., Maitland-Van Der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Roussel, R., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Hopewell, J. C., Seshadri, S., Dale, C., Costa, R. P. E., Ridker, P. M., Chasman, D. I., Reiner, A. P., Ritchie, M. D., Lange, L. A., Cornish, A. J., Dobbins, S. E., Hemminki, K., Kinnersley, B., Sanson, M., Labreche, K., Simon, M., Bondy, M., Law, P., Speedy, H., Allan, J., Li, N., Went, M., Weinhold, N., Morgan, G., Sonneveld, P., Nilsson, B., Goldschmidt, H., Sud, A., Engert, A., Hansson, M., Hemingway, H., Asselbergs, F. W., Patel, R. S., Keating, B. J., Sattar, N., Houlston, R., Casas, J. P. & Hingorani, A. D., 2019, In : BMC Cardiovascular Disorders. 19, 1, 240.

Research output: Contribution to journalArticle

Open Access

Physical inactivity, cardiometabolic disease, and risk of dementia: An individual-participant meta-analysis

Kivimäki, M., Singh-Manoux, A., Pentti, J., Sabia, S., Nyberg, S. T., Alfredsson, L., Goldberg, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Kouvonen, A., Nordin, M., Oksanen, T., Strandberg, T., Suominen, S. B., Theorell, T., Vahtera, J., Väänänen, A., Virtanen, M., Westerholm, P. & 9 others, Westerlund, H., Zins, M., Seshadri, S., Batty, G. D., Sipilä, P. N., Shipley, M. J., Lindbohm, J. V., Ferrie, J. E. & Jokela, M., 2019, In : BMJ (Online). 365, l1495.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Plasma total-tau as a biomarker of stroke risk in the community

Pase, M. P., Himali, J. J., Aparicio, H. J., Romero, J. R., Satizabal, C. L., Maillard, P., DeCarli, C., Beiser, A. S. & Seshadri, S., Jan 1 2019, In : Annals of neurology. 86, 3, p. 463-467 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Prevention of Dementia - Thinking beyond the Age and Amyloid Boxes

Seshadri, S., Jan 1 2019, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalEditorial

Publisher correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes(Nature Genetics, (2018) 50, 4, (524-537), 10.1038/s41588-018-0058-3)

AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study & MEGASTROKE Consortium, 2019, In : Nature Genetics. 51, 7, p. 1192-1193 2 p.

Research output: Contribution to journalComment/debate

Open Access

Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project

Alzheimer's Disease Sequencing Project (ADSP), Jul 2019, In : Genomics. 111, 4, p. 808-818 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Response by Aparicio et al to letter regarding article, "temporal trends in ischemic stroke incidence in younger adults in the framingham study"

Aparicio, H. J., Beiser, A. S. & Seshadri, S., Dec 1 2019, In : Stroke. 50, 12, p. E425

Research output: Contribution to journalLetter