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  • Robert A Hromas

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

Daley, J. M., Tomimatsu, N., Hooks, G., Wang, W., Miller, A. S., Xue, X., Nguyen, K. A., Kaur, H., Williamson, E., Mukherjee, B., Hromas, R., Burma, S. & Sung, P., Dec 1 2020, In : Nature communications. 11, 1, 3088.

Research output: Contribution to journalArticle

Open Access

The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair

Liang, F., Miller, A. S., Tang, C., Maranon, D., Williamson, E. A., Hromas, R. A., Wiese, C., Zhao, W., Sung, P. & Kupfer, G. M., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8186-8194 9 p.

Research output: Contribution to journalArticle

The splicing component ISY1 regulates APE1 in base excision repair

Jaiswal, A. S., Williamson, E. A., Srinivasan, G., Kong, K., Lomelino, C. L., McKenna, R., Walter, C., Sung, P., Narayan, S. & Hromas, R., Feb 2020, In : DNA Repair. 86, 102769.

Research output: Contribution to journalArticle

Open Access
2019

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., Pei, J., Zhang, W., Sharma, A., McCurdy, C. R., Kuruvilla, V. M., Baran, N., Ferrando, A. A., Kim, Y. M., Rogojina, A., Houghton, P. J. & 5 others, Huang, G., Hromas, R., Konopleva, M., Zheng, G. & Zhou, D., Dec 1 2019, In : Nature Medicine. 25, 12, p. 1938-1947 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

Liang, F., Miller, A. S., Longerich, S., Tang, C., Maranon, D., Williamson, E. A., Hromas, R., Wiese, C., Kupfer, G. M. & Sung, P., Dec 1 2019, In : Nature communications. 10, 1, 2849.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers

Srinivasan, G., Williamson, E. A., Kong, K., Jaiswal, A. S., Huang, G., Kim, H. S., Schärer, O., Zhao, W., Burma, S., Sung, P. & Hromas, R., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17438-17443 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high-grade gliomas

Todorova, P. K., Fletcher-Sananikone, E., Mukherjee, B., Kollipara, R., Vemireddy, V., Xie, X. J., Guida, P. M., Story, M. D., Hatanpaa, K., Habib, A. A., Kittler, R., Bachoo, R., Hromas, R., Floyd, J. R. & Burma, S., 2019, In : Cancer Research. 79, 14, p. 3749-3761 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

The BRCA tumor suppressor network in chromosome damage repair by homologous recombination

Zhao, W., Wiese, C., Kwon, Y., Hromas, R. & Sung, P., Jun 20 2019, In : Annual Review of Biochemistry. 88, p. 221-245 25 p.

Research output: Contribution to journalReview article

11 Scopus citations
2018

A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1–Dna2 in long-range DNA end resection

Wang, W., Daley, J. M., Kwon, Y., Xue, X., Krasner, D. S., Miller, A. S., Nguyen, K. A., Williamson, E. A., Shim, E. Y., Lee, S. E., Hromas, R. & Sung, P., Nov 2 2018, In : Journal of Biological Chemistry. 293, 44, p. 17061-17069 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Approaching the crisis in medical research funding: an important role for nonprofit organizations and medical societies

Abkowitz, J. L. & Hromas, R. A., Apr 24 2018, In : Blood advances. 2, 8, p. 846-847 2 p.

Research output: Contribution to journalLetter

Open Access

Confronting the research funding crisis: Medical societies' role in filling the gap

Abkowitz, J. L. & Hromas, R., Jul 1 2018, In : Academic Medicine. 93, 7, p. 961-962 2 p.

Research output: Contribution to journalLetter

1 Scopus citations

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Shao, L., Chang, J., Feng, W., Wang, X., Williamson, E. A., Li, Y., Schajnovitz, A., Scadden, D., Mortensen, L. J., Lin, C. P., Li, L., Paulson, A., Downing, J., Zhou, D. & Hromas, R. A., Dec 1 2018, In : Nature communications. 9, 1, 2377.

Research output: Contribution to journalArticle

2 Scopus citations

What a medical school chair wants from the dean

Hromas, R., Leverence, R., Mramba, L. K., Jameson, J. L., Lerman, C., Schwenk, T. L., Zimmermann, E. M. & Good, M. L., Jan 1 2018, In : Journal of Healthcare Leadership. 10, p. 33-44 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Drugging the Cancers Addicted to DNA Repair

Nickoloff, J. A., Jones, D., Lee, S. H., Williamson, E. A. & Hromas, R., Nov 1 2017, In : Journal of the National Cancer Institute. 109, 11, djx059.

Research output: Contribution to journalReview article

43 Scopus citations

Endonuclease EEPD1 Is a gatekeeper for repair of stressed replication forks

Kim, H. S., Nickoloff, J. A., Wu, Y., Williamson, E. A., Sidhu, G. S., Reinert, B. L., Jaiswal, A. S., Srinivasan, G., Patel, B., Kong, K., Burma, S., Lee, S. H. & Hromas, R. A., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2795-2804 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Metnase mediates loading of exonuclease 1 onto single strand overhang DNA for end resection at stalled replication forks

Kim, H. S., Williamson, E. A., Nickoloff, J. A., Hromas, R. A. & Lee, S. H., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1414-1425 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Minimal residual disease by either flow cytometry or cytogenetics prior to an allogeneic hematopoietic stem cell transplant is associated with poor outcome in acute myeloid leukemia

Norkin, M., Katragadda, L., Zou, F., Xiong, S., Chang, M., Dai, Y., Hsu, J. W., Moreb, J. S., Leather, H., Murthy, H. S., Farhadfar, N., Li, Y., Hromas, R., Brown, R. A., Cogle, C. R. & Wingard, J. R., Dec 1 2017, In : Blood Cancer Journal. 7, 12, 634.

Research output: Contribution to journalArticle

6 Scopus citations

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

Narayan, S., Jaiswal, A. S., Sharma, R., Nawab, A., Duckworth, L. V., Law, B. K., Zajac-Kaye, M., George, T. J., Sharma, J., Sharma, A. K. & Hromas, R. A., Jan 1 2017, In : Oncotarget. 8, 34, p. 57246-57264 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

Srinivasan, G., Sidhu, G. S., Williamson, E. A., Jaiswal, A. S., Najmunnisa, N., Wilcoxen, K., Jones, D., George, T. J. & Hromas, R., Oct 1 2017, In : Cancer chemotherapy and pharmacology. 80, 4, p. 861-867 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells

Hromas, R., Kim, H. S., Sidhu, G., Williamson, E., Jaiswal, A., Totterdale, T. A., Nole, J., Lee, S. H., Nickoloff, J. A. & Kong, K. Y., Nov 16 2017, In : Breast Cancer Research. 19, 1, 122.

Research output: Contribution to journalArticle

9 Scopus citations

Using Organizational Philosophy to Create a Self-Sustaining Compensation Plan Without Harming Academic Missions

Leverence, R., Nuttall, R., Palmer, R., Segal, M., Wood, A., Yancey, F., Shuster, J., Brantly, M. & Hromas, R., Aug 1 2017, In : Academic Medicine. 92, 8, p. 1133-1137 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Sullivan, K., Cramer-Morales, K., McElroy, D. L., Ostrov, D. A., Haas, K., Childers, W., Hromas, R. & Skorski, T., Jan 1 2016, In : PloS one. 11, 1, e0147230.

Research output: Contribution to journalArticle

34 Scopus citations

Interaction between APC and Fen1 during breast carcinogenesis

Narayan, S., Jaiswal, A. S., Law, B. K., Kamal, M. A., Sharma, A. K. & Hromas, R. A., May 1 2016, In : DNA Repair. 41, p. 54-62 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER

Hromas, R., Williamson, E., Lee, S. H. & Nickoloff, J., Jan 1 2016, In : Transactions of the American Clinical and Climatological Association. 127, p. 176-195 20 p.

Research output: Contribution to journalArticle

6 Scopus citations

The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis

Chun, C., Wu, Y., Lee, S. H., Williamson, E. A., Reinert, B. L., Jaiswal, A. S., Nickoloff, J. A. & Hromas, R. A., Apr 2 2016, In : Cell Cycle. 15, 7, p. 957-962 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair

Wu, Y., Lee, S. H., Williamson, E. A., Reinert, B. L., Cho, J. H., Xia, F., Jaiswal, A. S., Srinivasan, G., Patel, B., Brantley, A., Zhou, D., Shao, L., Pathak, R., Hauer-Jensen, M., Singh, S., Kong, K., Wu, X., Kim, H. S., Beissbarth, T., Gaedcke, J. & 3 others, Burma, S., Nickoloff, J. A. & Hromas, R. A., Jan 1 2015, In : PLoS Genetics. 11, 12, e1005675.

Research output: Contribution to journalArticle

25 Scopus citations

Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry

Lebedyeva, I. O., Oliferenko, A. A., Oliferenko, P. V., Hromas, R. A., Neubert, J. K., Caudle, R. M., Wickersham, J., Castleman, W. L., Altschuler, G. I., Ostrov, D. A., Hall, C. D. & Katritzky, A. R., Sep 23 2015, In : Journal of Materials Chemistry B. 3, 43, p. 8492-8498 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

NSC666715 and Its analogs inhibit strand-displacement activity of DNA polymerase β and potentiate temozolomide-induced DNA damage, senescence and apoptosis in colorectal cancer cells

Jaiswal, A. S., Panda, H., Law, B. K., Sharma, J., Jani, J., Hromas, R. & Narayan, S., May 1 2015, In : PLoS One. 10, 5, e0123808.

Research output: Contribution to journalArticle

10 Scopus citations

The set domain is essential for metnase functions in replication restart and the 5' end of ss-overhang cleavage

Kim, H. S., Kim, S. K., Hromas, R. & Lee, S. H., Oct 5 2015, In : PloS one. 10, 10, e0139418.

Research output: Contribution to journalArticle

5 Scopus citations

Two novel RUNX1 mutations in a patient with congenital thrombocytopenia that evolved into a high grade myelodysplastic syndrome

Schmit, J. M., Turner, D. J., Hromas, R. A., Wingard, J. R., Brown, R. A., Li, Y., Li, M. M., Slayton, W. B. & Cogle, C. R., Mar 1 2015, In : Leukemia Research Reports. 4, 1, p. 24-27 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Disease-specific survival for patients with multiple myeloma: Significant improvements over time in all age groups

Libby, E., Garcia, D., Quintana, D., Fekrazad, M. H., Bauman, J., Ebaid, A., Hromas, R., Rabinowitz, I. & Wiggins, C., Dec 1 2014, In : Leukemia and Lymphoma. 55, 12, p. 2850-2857 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Erratum: Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

Hromas, R., Williamson, E. A., Fnu, S., Lee, Y. J., Park, S. J., Beck, B. D., You, J. S., Leitao, A., Nickoloff, J. A. & Lee, S. H., Jan 23 2014, In : Oncogene. 33, 4, 1 p.

Research output: Contribution to journalComment/debate

Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing

Rath, A., Hromas, R. & De Benedetti, A., Mar 22 2014, In : BMC Molecular Biology. 15, 6.

Research output: Contribution to journalArticle

4 Scopus citations

Functional integration of acute myeloid leukemia into the vascular niche

Cogle, C. R., Goldman, D. C., Madlambayan, G. J., Leon, R. P., Al Masri, A., Clark, H. A., Asbaghi, S. A., Tyner, J. W., Dunlap, J., Fan, G., Kovacsovics, T., Liu, Q., Meacham, A., Hamlin, K. L., Hromas, R. A., Scott, E. W. & Fleming, W. H., Oct 1 2014, In : Leukemia. 28, 10, p. 1978-1987 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Mechanisms of oncogenic chromosomal translocations

Byrne, M., Wray, J., Reinert, B., Wu, Y., Nickoloff, J., Lee, S. H., Hromas, R. & Williamson, E., Mar 2014, In : Annals of the New York Academy of Sciences. 1310, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

Kim, H. S., Chen, Q., Kim, S. K., Nickoloff, J. A., Hromas, R., Georgiadis, M. M. & Lee, S. H., Apr 11 2014, In : Journal of Biological Chemistry. 289, 15, p. 10930-10938 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

The DNA repair component Metnase regulates Chk1 stability

Williamson, E. A., Wu, Y., Singh, S., Byrne, M., Wray, J., Lee, S. H., Nickoloff, J. A. & Hromas, R., Jul 9 2014, In : Cell Division. 9, 1, 1.

Research output: Contribution to journalArticle

4 Scopus citations

The role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination

Abbas, M., Shanmugam, I., Bsaili, M., Hromas, R. & Shaheen, M., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14009-14019 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination

Shanmugam, I., Abbas, M., Ayoub, F., Mirabal, S., Bsaili, M., Caulder, E. K., Weinstock, D. M., Tomkinson, A. E., Hromas, R. & Shaheen, M., Aug 15 2014, In : Journal of Biological Chemistry. 289, 33, p. 22739-22748 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Adenomatous polyposis coli- mediated accumulation of abasic dna lesions lead to cigarette smoke condensate- induced neoplastic transformation of normal breast epithelial cells

Jaiswal, A. S., Panda, H., Pampo, C. A., Siemann, D. W., Gary Gairola, C., Hromas, R. & Narayan, S., Apr 2013, In : Neoplasia (United States). 15, 4, p. 454-460 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

PARP1 is required for chromosomal translocations

Wray, J., Williamson, E. A., Singh, S. B., Wu, Y., Cogle, C. R., Weinstock, D. M., Zhang, Y., Lee, S. H., Zhou, D., Shao, L., Hauer-Jensen, M., Pathak, R., Klimek, V., Nickoloff, J. A. & Hromas, R., May 23 2013, In : Blood. 121, 21, p. 4359-4365 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Repressing DNA repair to enhance chemotherapy: Targeting MyD88 in colon cancer

Williamson, E. A. & Hromas, R., Jul 3 2013, In : Journal of the National Cancer Institute. 105, 13, p. 926-927 2 p.

Research output: Contribution to journalEditorial

6 Scopus citations

Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases

Mohapatra, S., Yannone, S. M., Lee, S. H., Hromas, R. A., Akopiants, K., Menon, V., Ramsden, D. A. & Povirk, L. F., Jun 1 2013, In : DNA Repair. 12, 6, p. 422-432 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

Hromas, R., Williamson, E. A., Fnu, S., Lee, Y. J., Park, S. J., Beck, B. D., You, J. S., Laitao, A., Nickoloff, J. A. & Lee, S. H., Sep 20 2012, In : Oncogene. 31, 38, p. 4245-4254 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cytotoxic activity of the titanium alkoxide (OPy) 2Ti(4AP) 2 against cancer colony forming cells

Williamson, E. A., Boyle, T. J., Raymond, R., Farrington, J., Verschraegen, C., Shaheen, M. & Hromas, R., Feb 1 2012, In : Investigational New Drugs. 30, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Facing the NIH funding crisis: How professional societies can help

Hromas, R., Abkowitz, J. L. & Keating, A., Dec 12 2012, In : JAMA - Journal of the American Medical Association. 308, 22, p. 2343-2344 2 p.

Research output: Contribution to journalShort survey

23 Scopus citations

Overview for the histone codes for DNA repair

Williamson, E. A., Wray, J. W., Bansal, P. & Hromas, R., 2012, Progress in Molecular Biology and Translational Science. Elsevier B.V., p. 207-227 21 p. (Progress in Molecular Biology and Translational Science; vol. 110).

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Targeting the transposase domain of the DNA repair component metnase to enhance chemotherapy

Williamson, E. A., Damiani, L., Leitao, A., Hu, C., Hathaway, H., Oprea, T., Sklar, L., Shaheen, M., Bauman, J., Wang, W., Nickoloff, J. A., Lee, S. H. & Hromas, R., Dec 1 2012, In : Cancer Research. 72, 23, p. 6200-6208 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

Biochemical characterization of metnases endonuclease activity and its role in NHEJ repair

Beck, B. D., Lee, S. S., Williamson, E., Hromas, R. A. & Lee, S. H., May 24 2011, In : Biochemistry. 50, 20, p. 4360-4370 11 p.

Research output: Contribution to journalArticle

28 Scopus citations