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  • Xianlin Han
2020

Can oral health and oral-derived biospecimens predict progression of dementia?

Orr, M. E., Reveles, K. R., Yeh, C. K., Young, E. H. & Han, X., Mar 1 2020, In : Oral Diseases. 26, 2, p. 249-258 10 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy

Cole, L. K., Mejia, E. M., Sparagna, G. C., Vandel, M., Xiang, B., Han, X., Dedousis, N., Kaufman, B. A., Dolinsky, V. W. & Hatch, G. M., Jul 2020, In : Journal of Molecular and Cellular Cardiology. 144, p. 24-34 11 p.

Research output: Contribution to journalArticle

Open Access

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

Miyamoto, S., Zhang, G., Hall, D., Oates, P. J., Maity, S., Madesh, M., Han, X. & Sharma, K., May 22 2020, In : Journal of Biological Chemistry. 295, 21, p. 7249-7260 12 p.

Research output: Contribution to journalArticle

Sensitive analysis of fatty acid esters of hydroxy fatty acids in biological lipid extracts by shotgun lipidomics after one-step derivatization

Hu, C., Wang, M., Duan, Q. & Han, X., Apr 8 2020, In : Analytica Chimica Acta. 1105, p. 105-111 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., John-Williams, L. S., Tenenbaum, J. D., Blach, C., Chang, R., Brinton, R. D., Baillie, R., Han, X., Trojanowski, J. Q., Shaw, L. M., Martins, R. & 10 others, Weiner, M. W., Trushina, E., Toledo, J. B., Meikle, P. J., Bennett, D. A., Krumsiek, J., Doraiswamy, P. M., Saykin, A. J., Kaddurah-Daouk, R. & Kastenmüller, G., Dec 1 2020, In : Nature communications. 11, 1, 1148.

Research output: Contribution to journalArticle

Open Access

Strategies to Improve/Eliminate the Limitations in Shotgun Lipidomics

Hu, C., Duan, Q. & Han, X., Jun 1 2020, In : Proteomics. 20, 11, 1900070.

Research output: Contribution to journalReview article

6 Scopus citations

The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

Mitchell, W., Ng, E. A., Tamucci, J. D., Boyd, K. J., Sathappa, M., Coscia, A., Pan, M., Han, X., Eddy, N. A., May, E. R., Szeto, H. H. & Alder, N. N., May 22 2020, In : Journal of Biological Chemistry. 295, 21, p. 7452-7469 18 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Rodriguez-Ayala, E., Gallegos-Cabrales, E. C., Gonzalez-Lopez, L., Laviada-Molina, H. A., Salinas-Osornio, R. A., Nava-Gonzalez, E. J., Leal-Berumen, I., Escudero-Lourdes, C., Escalante-Araiza, F., Buenfil-Rello, F. A., Peschard, V. G., Laviada-Nagel, A., Silva, E., Veloz-Garza, R. A., Martinez-Hernandez, A., Barajas-Olmos, F. M., Molina-Segui, F., Gonzalez-Ramirez, L., Espadas-Olivera, R., Lopez-Muñoz, R. & 29 others, Arjona-Villicaña, R. D., Hernandez-Escalante, V. M., Rodriguez-Arellano, M. E., Gaytan-Saucedo, J. F., Vaquera, Z., Acebo-Martinez, M., Cornejo-Barrera, J., Jancy Andrea, H. Q., Castillo-Pineda, J. C., Murillo-Ramirez, A., Diaz-Tena, S. P., Figueroa-Nuñez, B., Valencia-Rendon, M. E., Garzon-Zamora, R., Viveros-Paredes, J. M., Ángeles-Chimal, J., Santa-Olalla Tapia, J., Remes-Troche, J. M., Valdovinos-Chavez, S. B., Huerta-Avila, E. E., Lopez-Alvarenga, J. C., Comuzzie, A. G., Haack, K., Han, X., Orozco, L., Weintraub, S., Kent, J. W., Cole, S. A. & Bastarrachea, R. A., Jan 1 2020, In : Adipocyte. 9, 1, p. 153-169 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, Jan 2019, In : Alzheimer's and Dementia. 15, 1, p. 76-92 17 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, Feb 2019, In : Alzheimer's and Dementia. 15, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice

Declèves, A. E., Mathew, A. V., Armando, A. M., Han, X., Dennis, E. A., Quehenberger, O. & Sharma, K., 2019, In : Journal of lipid research. 60, 5, p. 937-952 16 p.

Research output: Contribution to journalArticle

Analytical challenges of shotgun lipidomics at different resolution of measurements

Wang, J. & Han, X., Dec 2019, In : TrAC - Trends in Analytical Chemistry. 121, 115697.

Research output: Contribution to journalReview article

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

Lefterov, I., Wolfe, C. M., Fitz, N. F., Nam, K. N., Letronne, F., Biedrzycki, R. J., Kofler, J., Han, X., Wang, J., Schug, J. & Koldamova, R., Dec 30 2019, In : Alzheimer's Research and Therapy. 11, 1, 113.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers

Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, Jul 3 2019, In : JAMA network open. 2, 7, p. e197978

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

Alzheimer’s Disease Neuroimaging Initiative & Alzheimer’s Disease Metabolomics Consortium, Oct 17 2019, In : Scientific Data. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis

Zhang, X., Zhang, J., Sun, H., Liu, X., Zheng, Y., Xu, D., Wang, J., Jia, D., Han, X., Liu, F., Nie, J. & Shi, Y., Jan 1 2019, In : CMGH. 7, 4, p. 763-781 19 p.

Research output: Contribution to journalArticle

Open Access

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

Giannakis, N., Sansbury, B. E., Patsalos, A., Hays, T. T., Riley, C. O., Han, X., Spite, M. & Nagy, L., May 1 2019, In : Nature Immunology. 20, 5, p. 626-636 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes

Pino, M. F., Stephens, N. A., Eroshkin, A. M., Yi, F., Hodges, A., Cornnell, H. H., Pratley, R. E., Smith, S. R., Wang, M., Han, X., Coen, P. M., Goodpaster, B. H. & Sparks, L. M., Nov 2019, In : Physiological Genomics. 51, 11, p. 586-595 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J. & Crawford, P. A., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 383-398.e7

Research output: Contribution to journalArticle

10 Scopus citations

Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy

Trevino, M. B., Zhang, X., Standley, R. A., Wang, M., Han, X., Reis, F. C. G., Periasamy, M., Yu, G., Kelly, D. P., Goodpaster, B. H., Vega, R. B. & Coen, P. M., 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 317, 5, p. E899-E910

Research output: Contribution to journalArticle

MondoA drives muscle lipid accumulation and insulin resistance

Ahn, B., Wan, S., Jaiswal, N., Vega, R. B., Ayer, D. E., Titchenell, P. M., Han, X., Won, K. J. & Kelly, D. P., Aug 8 2019, In : JCI Insight. 4, 15, e129119.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc 1 complex function

Calzada, E., Avery, E., Sam, P. N., Modak, A., Wang, C., McCaffery, J. M., Han, X., Alder, N. N. & Claypool, S. M., Dec 1 2019, In : Nature communications. 10, 1, 1432.

Research output: Contribution to journalArticle

14 Scopus citations

Publisher Correction: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration (Nature Immunology, (2019), 20, 5, (626-636), 10.1038/s41590-019-0356-7)

Giannakis, N., Sansbury, B. E., Patsalos, A., Hays, T. T., Riley, C. O., Han, X., Spite, M. & Nagy, L., Jun 1 2019, In : Nature Immunology. 20, 6, p. 765-767 3 p.

Research output: Contribution to journalComment/debate

Open Access

Role of mitochondria in the regulation of kidney function and metabolism in type 2 diabetes

Han, X., Shi, Y., Diamond-Stanic, M. & Sharma, K., Jan 1 2019, Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases. Elsevier, p. 287-300 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors

Gao, C. Z., Dong, W., Cui, Z. W., Yuan, Q., Hu, X. M., Wu, Q. M., Han, X., Xu, Y. & Min, Z. L., Jan 1 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 150-162 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tutorial on lipidomics

Wang, J., Wang, C. & Han, X., Jul 11 2019, In : Analytica Chimica Acta. 1061, p. 28-41 14 p.

Research output: Contribution to journalReview article

22 Scopus citations
2018

A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction

Killion, E. A., Reeves, A. R., El Azzouny, M. A., Yan, Q. W., Surujon, D., Griffin, J. D., Bowman, T. A., Wang, C., Matthan, N. R., Klett, E. L., Kong, D., Newman, J. W., Han, X., Lee, M. J., Coleman, R. A. & Greenberg, A. S., Mar 2018, In : Molecular Metabolism. 9, p. 43-56 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 others, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, A., Pedersen, O., Kiebish, M. A., Qvortrup, K., Han, X., Pedersen, B. K., Jastroch, M., Mandrup, S., Kjær, A., Gygi, S. P., Hansen, T., Gillum, M. P., Grarup, N., Emanuelli, B., Nielsen, S., Scheele, C., Tseng, Y. H., Færgeman, N. J. & Gerhart-Hines, Z., Jul 3 2018, In : Cell Metabolism. 28, 1, p. 159-174.e11

Research output: Contribution to journalArticle

25 Scopus citations

Deep multi-OMICs and multi-tissue characterization in a pre-and postprandial state in human volunteers: The GEMM family study research design

Bastarrachea, R. A., Laviada-Molina, H. A., Nava-Gonzalez, E. J., Leal-Berumen, I., Escudero-Lourdes, C., Escalante-Araiza, F., Peschard, V. G., Veloz-Garza, R. A., Haack, K., Martínez-Hernández, A., Barajas-Olmos, F. M., Molina-Segui, F., Buenfil-Rello, F. A., Gonzalez-Ramirez, L., Janssen-Aguilar, R., Lopez-Muñoz, R., Perez-Cetina, F., Gaytan-Saucedo, J. F., Vaquera, Z., Cornejo-Barrera, J. & 19 others, Castillo-Pineda, J. C., Murillo-Ramirez, A., Diaz-Tena, S. P., Figueroa-Nuñez, B., González-López, L., Salinas-Osornio, R. A., Valencia-Rendón, M. E., Ángeles-Chimal, J., Tapia, J. S. O., Remes-Troche, J. M., Valdovinos-Chavez, S. B., Huerta-Avila, E. E., Han, X., Orozco, L., Rodriguez-Ayala, E., Weintraub, S., Gallegos-Cabrales, E. C., Cole, S. A. & Kent, J. W., Nov 2 2018, In : Genes. 9, 11, 532.

Research output: Contribution to journalArticle

3 Scopus citations
12 Scopus citations

Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

d'Avignon, D. A., Puchalska, P., Ercal, B., Chang, Y. J., Martin, S. E., Graham, M. J., Patti, G. J., Han, X. & Crawford, P. A., Jun 21 2018, In : JCI insight. 3, 12

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice

Zhang, X., Trevino, M. B., Wang, M., Gardell, S. J., Ayala, J. E., Han, X., Kelly, D. P., Goodpaster, B. H., Vega, R. B. & Coen, P. M., Sep 11 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 10, p. 1313-1322 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments

Puchalska, P., Huang, X., Martin, S. E., Han, X., Patti, G. J. & Crawford, P. A., Nov 30 2018, In : iScience. 9, p. 298-313 16 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Is the clinical lipidomics a potential goldmine?

Zhang, L., Han, X. & Wang, X., Jan 1 2018, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

9 Scopus citations

Lipidomic analysis reveals significant lipogenesis and accumulation of lipotoxic components in ob/ob mouse organs

Hayakawa, J., Wang, M., Wang, C., Han, R. H., Jiang, Z. Y. & Han, X., Sep 2018, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 136, p. 161-169 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lipidomics profiling of myelin

Wang, C., Palavicini, J. P. & Han, X., Jan 1 2018, Methods in Molecular Biology. Humana Press, p. 37-50 14 p. (Methods in Molecular Biology; vol. 1791).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure

Wang, C., Liu, F., Frisch-Daiello, J. L., Martin, S., Patterson, T. A., Gu, Q., Liu, S., Paule, M. G., Hanig, J. P., Slikker, W., Crawford, P. A., Wang, C. & Han, X., Dec 11 2018, In : Analytica Chimica Acta. 1037, p. 87-96 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains

Wang, C., Wang, C., Liu, F., Rainosek, S., Patterson, T. A., Slikker, W. & Han, X., Sep 17 2018, In : Chemical Research in Toxicology. 31, 9, p. 825-835 11 p.

Research output: Contribution to journalReview article

Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains

Wang, C., Wang, C., Liu, F., Rainosek, S., Patterson, T. A., Slikker, W. & Han, X., Sep 17 2018, In : Chemical research in toxicology. 31, 9, p. 825-835 11 p.

Research output: Contribution to journalArticle

Lipid profiling as an effective approach for identifying biomarkers/adverse events associated with pediatric anesthesia

Wang, C., Han, X., Liu, F., Patterson, T. A., Hanig, J. P., Paule, M. G. & Slikker, W., Sep 1 2018, In : Toxicology and Applied Pharmacology. 354, p. 191-195 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity

Senagolage, M. D., Sommars, M. A., Ramachandran, K., Futtner, C. R., Omura, Y., Allred, A. L., Wang, J., Yang, C., Procissi, D., Evans, R. M., Han, X., Bederman, I. R. & Barish, G. D., Dec 18 2018, In : Cell Reports. 25, 12, p. 3283-3298.e6

Research output: Contribution to journalArticle

4 Scopus citations

MS-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines

Burla, B., Arita, M., Arita, M., Bendt, A. K., Cazenave-Gassiot, A., Dennis, E. A., Ekroos, K., Han, X., Ikeda, K., Liebisch, G., Lin, M. K., Loh, T. P., Meikle, P. J., Orešič, M., Quehenberger, O., Shevchenko, A., Torta, F., Wakelam, M. J. O., Wheelock, C. E. & Wenk, M. R., 2018, In : Journal of lipid research. 59, 10, p. 2001-2017 17 p.

Research output: Contribution to journalArticle

64 Scopus citations

Novel strategies for enhancing shotgun lipidomics for comprehensive analysis of cellular lipidomes

Hu, C., Wang, C., He, L. & Han, X., Jan 1 2018, (Accepted/In press) In : TrAC - Trends in Analytical Chemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase

Schlegel, C., Lapierre, L. A., Weis, V. G., Williams, J. A., Kaji, I., Pinzon-Guzman, C., Prasad, N., Boone, B., Jones, A., Correa, H., Levy, S. E., Han, X., Wang, M., Thomsen, K., Acra, S. & Goldenring, J. R., Nov 2018, In : Traffic. 19, 11, p. 879-892 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Shotgun lipidomics revealed altered profiles of serum lipids in systemic lupus erythematosus closely associated with disease activity

Lu, L., Hu, C., Zhao, Y., He, L., Zhou, J., Li, H., Du, Y., Wang, Y., Wen, C., Han, X. & Fan, Y., Dec 1 2018, In : Biomolecules. 8, 4, 105.

Research output: Contribution to journalArticle

4 Scopus citations

Sphingolipid metabolic pathway impacts thiazide diuretics blood pressure response: Insights from genomics, metabolomics, and lipidomics

Shahin, M. H., Gong, Y., Frye, R. F., Rotroff, D. M., Beitelshees, A. L., Baillie, R. A., Chapman, A. B., Gums, J. G., Turner, S. T., Boerwinkle, E., Motsinger-Reif, A., Fiehn, O., Cooper-DeHoff, R. M., Han, X., Kaddurah-Daouk, R. & Johnson, J. A., Jan 1 2018, In : Journal of the American Heart Association. 7, 1, e006656.

Research output: Contribution to journalArticle

4 Scopus citations

SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1

Lee, J. H., Phelan, P., Shin, M., Oh, B. C., Han, X., Im, S. S. & Osborne, T. F., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12228-E12234

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2017

A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels

Cabanos, C., Wang, M., Han, X. & Hansen, S. B., Aug 8 2017, In : Cell Reports. 20, 6, p. 1287-1294 8 p.

Research output: Contribution to journalArticle

16 Scopus citations