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  • Robert A Clark
2020

Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice

Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J. A. L., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A. & Li, S., Mar 1 2020, In : Aging cell. 19, 3, e13110.

Research output: Contribution to journalArticle

Open Access

Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson's Disease

Chen, C., Guderyon, M. J., Li, Y., Ge, G., Bhattacharjee, A., Ballard, C., He, Z., Masliah, E., Clark, R. A., O'Connor, J. C. & Li, S., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 83-98 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Functional MRI of the mouse olfactory system

Muir, E. R., Biju, K. C., Cong, L., Rogers, W. E., Torres Hernandez, E., Duong, T. Q. & Clark, R. A., Jun 21 2019, In : Neuroscience Letters. 704, p. 57-61 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

intersecting stories of the phagocyte NADPH oxidase and chronic granulomatous disease

Nauseef, W. M. & Clark, R. A., Jan 1 2019, Methods in Molecular Biology. Humana Press, p. 3-16 14 p. (Methods in Molecular Biology; vol. 1982).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Lentiviral Infection of Mouse Bone Marrow Cells for Hematopoietic Stem Cell Transplantation

Chen, C., Guderyon, M. J., Ge, G., Clark, R. A. & Li, S., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1919, p. 205-213 9 p.

Research output: Contribution to journalArticle

Reduced cerebral blood flow in an α-synuclein transgenic mouse model of Parkinson’s disease

Biju, K. C., Shen, Q., Hernandez, E. T., Mader, M. J. & Clark, R. A., Jan 1 2019, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

2018

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice

Chen, C., Li, X., Ge, G., Liu, J., Biju, K. C., Laing, S. D., Qian, Y., Ballard, C., He, Z., Masliah, E., Clark, R. A., O'Connor, J. C. & Li, S., Dec 1 2018, In : Scientific reports. 8, 1, 5460.

Research output: Contribution to journalArticle

10 Scopus citations

Methylene Blue Ameliorates Olfactory Dysfunction and Motor Deficits in a Chronic MPTP/Probenecid Mouse Model of Parkinson's Disease

Biju, K. C., Evans, R. C., Shrestha, K., Carlisle, D. C. B., Gelfond, J. & Clark, R. A., Jun 1 2018, In : Neuroscience. 380, p. 111-122 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulatable lentiviral hematopoietic stem cell gene therapy in a mouse model of Parkinson's disease

Ge, G., Chen, C., Guderyon, M. J., Liu, J., He, Z., Yu, Y., Clark, R. A. & Li, S., Jul 15 2018, In : Stem Cells and Development. 27, 14, p. 995-1005 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge

Ahuja, S. K., Manoharan, M. S., Harper, N. L., Jimenez, F., Hobson, B. D., Martinez, H., Ingale, P., Liu, Y. G., Carrillo, A., Lou, Z., Kellog, D. L., Ahuja, S. S., Rather, C. G., Esch, R. E., Ramirez, D. A., Clark, R. A., Nadeau, K., Andrews, C. P., Jacobs, R. L. & He, W., Mar 2017, In : Journal of Allergy and Clinical Immunology. 139, 3, p. 844-854 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016
1 Scopus citations

Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR-/- mice

Li, G., Chen, C., Laing, S. D., Ballard, C., Biju, K. C., Reddick, R. L., Clark, R. A. & Li, S., Jan 1 2016, In : Gene Therapy. 23, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Multimodal MRI evaluation of the mitopark mouse model of Parkinson's disease

Cong, L., Muir, E. R., Chen, C., Qian, Y., Liu, J., Biju, K. C., Clark, R. A., Li, S. & Duong, T. Q., Mar 2016, In : PloS one. 11, 3, e0151884.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen

He, W., Jimenez, F., Martinez, H., Harper, N. L., Manoharan, M. S., Carrillo, A., Ingale, P., Liu, Y., Ahuja, S. S., Clark, R. A., Rather, C. G., Ramirez, D. A., Andrews, C. P., Jacobs, R. L. & Ahuja, S. K., Sep 1 2015, In : Journal of Allergy and Clinical Immunology. 136, 3, p. 658-666 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor

Gornalusse, G. G., Mummidi, S., Gaitan, A. A., Jimenez, F., Ramsuran, V., Picton, A., Rogers, K., Manoharan, M. S., Avadhanam, N., Murthy, K. K., Martinez, H., Murillo, A. M., Chykarenko, Z. A., Hutt, R., Daskalakis, D., Shostakovich-Koretskaya, L., Karim, S. A., Martin, J. N., Deeks, S. G., Hecht, F. & 10 others, Sinclair, E., Clark, R. A., Okulicz, J., Valentine, F. T., Martinson, N., Tiemessen, C. T., Ndung'U, T., Hunt, P. W., He, W. & Ahuja, S. K., Aug 25 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 34, p. E4762-E4771

Research output: Contribution to journalArticle

24 Scopus citations

Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals

Okulicz, J. F., Le, T. D., Agan, B. K., Camargo, J. F., Landrum, M. L., Wright, E., Dolan, M. J., Ganesan, A., Ferguson, T. M., Smith, D. M., Richman, D. D., Little, S. J., Clark, R. A., He, W. & Ahuja, S. K., Jan 1 2015, In : JAMA internal medicine. 175, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet

De Figueiredo, A. S. P., Salmon, A. B., Bruno, F., Jimenez, F., Martinez, H. G., Halade, G. V., Ahuja, S. S., Clark, R. A., DeFronzo, R. A., Abboud, H. E. & El Jamali, A., May 22 2015, In : Journal of Biological Chemistry. 290, 21, p. 13427-13439 13 p.

Research output: Contribution to journalArticle

46 Scopus citations
2013

Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling

Valente, A. J., Yoshida, T., Clark, R. A., Delafontaine, P., Siebenlist, U. & Chandrasekar, B., Jul 1 2013, In : Free Radical Biology and Medicine. 60, p. 125-135 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease

Biju, K. C., Santacruz, R. A., Chen, C., Zhou, Q., Yao, J., Rohrabaugh, S. L., Clark, R. A., Roberts, J. L., Phillips, K. A., Imam, S. Z. & Li, S., Feb 22 2013, In : Neuroscience Letters. 535, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy

Le, T., Wright, E. J., Smith, D. M., He, W., Catano, G., Okulicz, J. F., Young, J. A., Clark, R. A., Richman, D. D., Little, S. J. & Ahuja, S. K., Jan 17 2013, In : New England Journal of Medicine. 368, 3, p. 218-230 13 p.

Research output: Contribution to journalArticle

227 Scopus citations

Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson's Disease Model

Imam, S. Z., Trickler, W., Kimura, S., Binienda, Z. K., Paule, M. G., Slikker, W., Li, S., Clark, R. A. & Ali, S. F., May 31 2013, In : PloS one. 8, 5, e65129.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Angiotensin II enhances AT 1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT 1, Nox1, and interleukin-18

Valente, A. J., Yoshida, T., Murthy, S. N., Sakamuri, S. S. V. P., Katsuyama, M., Clark, R. A., Delafontaine, P. & Chandrasekar, B., Aug 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 3, p. 282-296 15 p.

Research output: Contribution to journalArticle

61 Scopus citations

CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy

Valente, A. J., Clark, R. A., Siddesha, J. M., Siebenlist, U. & Chandrasekar, B., Jul 1 2012, In : Journal of Molecular and Cellular Cardiology. 53, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

NOX5 in human spermatozoa: Expression, function, and regulation

Musset, B., Clark, R. A., DeCoursey, T. E., Petheo, G. L., Geiszt, M., Chen, Y., Cornell, J. E., Eddy, C. A., Brzyski, R. G. & El Jamali, A., Mar 16 2012, In : Journal of Biological Chemistry. 287, 12, p. 9376-9388 13 p.

Research output: Contribution to journalArticle

82 Scopus citations
13 Scopus citations
2011

Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates

Catano, G., Chykarenko, Z. A., Mangano, A., Anaya, J. M., He, W., Smith, A., Bologna, R., Sen, L., Clark, R. A., Lloyd, A., Shostakovich-Koretskaya, L. & Ahuja, S. K., Jan 15 2011, In : Journal of Infectious Diseases. 203, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women

Ramsuran, V., Kulkarni, H., He, W., Mlisana, K., Wright, E. J., Werner, L., Castiblanco, J., Dhanda, R., Le, T., Dolan, M. J., Guan, W., Weiss, R. A., Clark, R. A., Abdool Karim, S. S., Ahuja, S. K. & Ndung'U, T., May 15 2011, In : Clinical Infectious Diseases. 52, 10, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR/mice

Li, G., Biju, K. C., Xu, X., Zhou, Q., Chen, C., Valente, A. J., He, W., Reddick, R. L., Freeman, G. L., Ahuja, S. S., Clark, R. A. & Li, S., Aug 1 2011, In : Gene Therapy. 18, 8, p. 835-841 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Novel regulation of Parkin function through c-Abl-mediated tyrosine phosphorylation: Implications for Parkinson's disease

Imam, S. Z., Zhou, Q., Yamamoto, A., Valente, A. J., Ali, S. F., Bains, M., Roberts, J. L., Kahle, P. J., Clark, R. A. & Li, S., Jan 5 2011, In : Journal of Neuroscience. 31, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

104 Scopus citations