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  • Peter J Houghton
2020

Age-associated genes in human mammary gland drive human breast cancer progression

Gu, X., Wang, B., Zhu, H., Zhou, Y., Horning, A. M., Huang, T. H. M., Chen, Y., Houghton, P., Lai, Z., Michalek, J. E. & Sun, L. Z., Jun 15 2020, In : Breast Cancer Research. 22, 1, 64.

Research output: Contribution to journalArticle

Open Access

Evaluation of VTP-50469, a menin-MLL1 inhibitor, against Ewing sarcoma xenograft models by the pediatric preclinical testing consortium

Kurmasheva, R. T., Bandyopadhyay, A., Favours, E., Pozo, V. D., Ghilu, S., Phelps, D. A., McGeehan, G. M., Erickson, S. W., Smith, M. A. & Houghton, P. J., Jul 1 2020, In : Pediatric Blood and Cancer. 67, 7, e28284.

Research output: Contribution to journalArticle

GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma

Charan, M., Dravid, P., Cam, M., Audino, A., Gross, A. C., Arnold, M. A., Roberts, R. D., Cripe, T. P., Pertsemlidis, A., Houghton, P. J. & Cam, H., Jun 1 2020, In : International Journal of Cancer. 146, 11, p. 3184-3195 12 p.

Research output: Contribution to journalArticle

Gli2 mediates the development of castration‑resistant prostate cancer

Xia, L., Bouamar, H., Gu, X., Zeballos, C., Qin, T., Wang, B., Zhou, Y., Wang, Y., Yang, J., Zhu, H., Zhang, W., Houghton, P. J. & Sun, L. Z., Jul 2020, In : International journal of oncology. 57, 1, p. 100-112 13 p.

Research output: Contribution to journalArticle

Open Access

Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

Harrison, D. J., Gill, J. D., Roth, M. E., Zhang, W., Teicher, B., Erickson, S., Gatto, G., Kurmasheva, R. T., Houghton, P. J., Smith, M. A., Kolb, E. A. & Gorlick, R., Jun 1 2020, In : Pediatric Blood and Cancer. 67, 6, e28222.

Research output: Contribution to journalArticle

Preclinical evaluation of the combination of AZD1775 and irinotecan against selected pediatric solid tumors: A Pediatric Preclinical Testing Consortium report

Kolb, E. A., Houghton, P. J., Kurmasheva, R. T., Mosse, Y. P., Maris, J. M., Erickson, S. W., Guo, Y., Teicher, B. A., Smith, M. A. & Gorlick, R., May 1 2020, In : Pediatric Blood and Cancer. 67, 5, e28098.

Research output: Contribution to journalArticle

Prospective use of the single-mouse experimental design for the evaluation of PLX038A

Ghilu, S., Li, Q., Fontaine, S. D., Santi, D. V., Kurmasheva, R. T., Zheng, S. & Houghton, P. J., Feb 1 2020, In : Cancer chemotherapy and pharmacology. 85, 2, p. 251-263 13 p.

Research output: Contribution to journalArticle

2019

A phase II study of alisertib in children with recurrent/refractory solid tumors or leukemia: Children's Oncology Group Phase I and pilot Consortium (ADVL0921)

Mosse, Y. P., Fox, E., Teachey, D. T., Reid, J. M., Safgren, S. L., Carol, H., Lock, R. B., Houghton, P. J., Smith, M. A., Hall, D., Barkauskas, D. A., Krailo, M., Voss, S. D., Berg, S. L., Blaney, S. M. & Weigel, B. J., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3229-3238 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., Pei, J., Zhang, W., Sharma, A., McCurdy, C. R., Kuruvilla, V. M., Baran, N., Ferrando, A. A., Kim, Y. M., Rogojina, A., Houghton, P. J. & 5 others, Huang, G., Hromas, R., Konopleva, M., Zheng, G. & Zhou, D., Dec 1 2019, In : Nature Medicine. 25, 12, p. 1938-1947 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Broad spectrum activity of the checkpoint kinase 1 inhibitor prexasertib as a single agent or chemopotentiator across a range of preclinical pediatric tumor models

Lowery, C. D., Dowless, M., Renschler, M., Blosser, W., VanWye, A. B., Stephens, J. R., Iversen, P. W., Lin, A. B., Beckmann, R. P., Krytska, K., Cole, K. A., Maris, J. M., Hawkins, D. S., Rubin, B. P., Kurmasheva, R. T., Houghton, P. J., Gorlick, R., Anders Kolb, E., Kang, M. H., Patrick Reynolds, C. & 4 others, Erickson, S. W., Teicher, B. A., Smith, M. A. & Stancato, L. F., Apr 1 2019, In : Clinical Cancer Research. 25, 7, p. 2278-2289 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2

Gardner, H. L., Sivaprakasam, K., Briones, N., Zismann, V., Perdigones, N., Drenner, K., Facista, S., Richholt, R., Liang, W., Aldrich, J., Trent, J. M., Shields, P. G., Robinson, N., Johnson, J., Lana, S., Houghton, P., Fenger, J., Lorch, G., Janeway, K. A., London, C. A. & 1 others, Hendricks, W. P. D., Dec 1 2019, In : Communications Biology. 2, 1, 266.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Challenges and opportunities for childhood cancer drug development

Houghton, P. J. & Kurmasheva, R. T., Oct 1 2019, In : Pharmacological Reviews. 71, 4, p. 671-697 27 p.

Research output: Contribution to journalArticle

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) new agents for ewing sarcoma task force [version 1; peer review: 3 approved]

Bailey, K., Cost, C., Davis, I., Glade-Bender, J., Grohar, P., Houghton, P., Isakoff, M., Stewart, E., Laack, N., Yustein, J., Reed, D., Janeway, K., Gorlick, R., Lessnick, S., DuBois, S. & Hingorani, P., 2019, In : F1000Research. 8, 493.

Research output: Contribution to journalReview article

Open Access
8 Scopus citations

Evaluation of entinostat alone and in combination with standard-of-care cytotoxic agents against rhabdomyosarcoma xenograft models

Kurmasheva, R. T., Bandyopadhyay, A. M., Favours, E., Del Pozo, V., Ghilu, S., Phelps, D. A., Erickson, S. W., Peer, C. J., Figg, W. D., Smith, M. A. & Houghton, P. J., Aug 2019, In : Pediatric Blood and Cancer. 66, 8, e27820.

Research output: Contribution to journalArticle

3 Scopus citations

Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

Murphy, A. J., Chen, X., Pinto, E. M., Williams, J. S., Clay, M. R., Pounds, S. B., Cao, X., Shi, L., Lin, T., Neale, G., Morton, C. L., Woolard, M. A., Mulder, H. L., Gil, H. J., Rehg, J. E., Billups, C. A., Harlow, M. L., Dome, J. S., Houghton, P. J., Easton, J. & 4 others, Zhang, J., George, R. E., Zambetti, G. P. & Davidoff, A. M., Dec 1 2019, In : Nature communications. 10, 1, 5806.

Research output: Contribution to journalArticle

Open Access

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

Rokita, J. L., Rathi, K. S., Cardenas, M. F., Upton, K. A., Jayaseelan, J., Cross, K. L., Pfeil, J., Egolf, L. E., Way, G. P., Farrel, A., Kendsersky, N. M., Patel, K., Gaonkar, K. S., Modi, A., Berko, E. R., Lopez, G., Vaksman, Z., Mayoh, C., Nance, J., McCoy, K. & 49 others, Haber, M., Evans, K., McCalmont, H., Bendak, K., Böhm, J. W., Marshall, G. M., Tyrrell, V., Kalletla, K., Braun, F. K., Qi, L., Du, Y., Zhang, H., Lindsay, H. B., Zhao, S., Shu, J., Baxter, P., Morton, C., Kurmashev, D., Zheng, S., Chen, Y., Bowen, J., Bryan, A. C., Leraas, K. M., Coppens, S. E., Doddapaneni, H. V., Momin, Z., Zhang, W., Sacks, G. I., Hart, L. S., Krytska, K., Mosse, Y. P., Gatto, G. J., Sanchez, Y., Greene, C. S., Diskin, S. J., Vaske, O. M., Haussler, D., Gastier-Foster, J. M., Kolb, E. A., Gorlick, R., Li, X. N., Reynolds, C. P., Kurmasheva, R. T., Houghton, P. J., Smith, M. A., Lock, R. B., Raman, P., Wheeler, D. A. & Maris, J. M., Nov 5 2019, In : Cell Reports. 29, 6, p. 1675-1689.e9

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase

Wu, X., Li, S., Hu, X., Xiang, X., Halloran, M., Yang, L., Williams, T. M., Houghton, P. J., Shen, C. & He, Z., Dec 1 2019, In : Scientific reports. 9, 1, 9805.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Preclinical activity of the antibody-drug conjugate denintuzumab mafodotin (SGN-CD19A) against pediatric acute lymphoblastic leukemia xenografts

Jones, L., McCalmont, H., Evans, K., Mayoh, C., Kurmasheva, R. T., Billups, C. A., Houghton, P. J., Smith, M. A. & Lock, R. B., Jan 1 2019, In : Pediatric Blood and Cancer. e27765.

Research output: Contribution to journalArticle

2 Scopus citations

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma

Sun, W., Chatterjee, B., Shern, J. F., Patidar, R., Song, Y., Wang, Y., Walker, R. L., Pawel, B. R., Linardic, C. M., Houghton, P. J., Hewitt, S. M., Edelman, D. C., Khan, J., Meltzer, P. S. & Barr, F. G., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Abemaciclib is active in preclinical models of Ewing sarcoma via multipronged regulation of cell cycle, DNA methylation, and interferon pathway signaling

Dowless, M., Lowery, C. D., Shackleford, T., Renschler, M., Stephens, J., Flack, R., Blosser, W., Gupta, S., Stewart, J., Webster, Y., Dempsey, J., VanWye, A. B., Ebert, P., Iversen, P., Olsen, J. B., Gong, X., Buchanan, S., Houghton, P. J. & Stancato, L., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 6028-6039 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Classical NF-κB metabolically reprograms sarcoma cells through regulation of hexokinase 2

Londhe, P., Yu, P. Y., Ijiri, Y., Ladner, K. J., Fenger, J. M., London, C., Houghton, P. J. & Guttridge, D. C., Apr 11 2018, In : Frontiers in Oncology. 8, APR, 104.

Research output: Contribution to journalArticle

11 Scopus citations

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

Harwood, F. C., Klein Geltink, R. I., O’Hara, B. P., Cardone, M., Janke, L., Finkelstein, D., Entin, I., Paul, L., Houghton, P. J. & Grosveld, G. C., Sep 12 2018, In : Science advances. 4, 9, eaar3938.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models

Bandyopadhyay, A., Favours, E., Phelps, D. A., Pozo, V. D., Ghilu, S., Kurmashev, D., Michalek, J., Trevino, A., Guttridge, D., London, C., Hirotani, K., Zhang, L., Kurmasheva, R. T. & Houghton, P. J., Feb 1 2018, In : Pediatric Blood and Cancer. 65, 2, e26870.

Research output: Contribution to journalArticle

3 Scopus citations

IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis

Gross, A. C., Cam, H., Phelps, D. A., Saraf, A. J., Bid, H. K., Cam, M., London, C. A., Winget, S. A., Arnold, M. A., Brandolini, L., Mo, X., Hinckley, J. M., Houghton, P. J. & Roberts, R. D., Aug 23 2018, In : JCI insight. 3, 16

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program

Kurmasheva, R. T., Kurmashev, D., Reynolds, C. P., Kang, M., Wu, J., Houghton, P. J. & Smith, M. A., Feb 1 2018, In : Pediatric Blood and Cancer. 65, 2, e26825.

Research output: Contribution to journalArticle

9 Scopus citations

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., Nov 12 2018, In : Cancer Cell. 34, 5, p. 807-822.e7

Research output: Contribution to journalArticle

28 Scopus citations

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Abdelfattah, N., Rajamanickam, S., Panneerdoss, S., Timilsina, S., Yadav, P., Onyeagucha, B. C., Garcia, M., Vadlamudi, R., Chen, Y., Brenner, A., Houghton, P. & Rao, M. K., Dec 1 2018, In : Nature communications. 9, 1, 4541.

Research output: Contribution to journalArticle

12 Scopus citations

The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

Breneman, J. C., Donaldson, S. S., Constine, L., Merchant, T., Marcus, K., Paulino, A. C., Followill, D., Mahajan, A., Laack, N., Esiashvili, N., Haas-Kogan, D., Laurie, F., Olch, A., Ulin, K., Hodgson, D., Yock, T. I., Terezakis, S., Krasin, M., Panoff, J., Chuba, P. & 7 others, Hua, C. H., Hess, C. B., Houghton, P. J., Wolden, S., Buchsbaum, J., Fitzgerald, T. J. & Kalapurakal, J. A., Jul 15 2018, In : International Journal of Radiation Oncology Biology Physics. 101, 4, p. 860-874 15 p.

Research output: Contribution to journalReview article

8 Scopus citations

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Mack, S. C., Pajtler, K. W., Chavez, L., Okonechnikov, K., Bertrand, K. C., Wang, X., Erkek, S., Federation, A., Song, A., Lee, C., Wang, X., McDonald, L., Morrow, J. J., Saiakhova, A., Sin-Chan, P., Wu, Q., Michaelraj, K. A., Miller, T. E., Hubert, C. G., Ryzhova, M. & 55 others, Garzia, L., Donovan, L., Dombrowski, S., Factor, D. C., Luu, B., Valentim, C. L. L., Gimple, R. C., Morton, A., Kim, L., Prager, B. C., Lee, J. J. Y., Wu, X., Zuccaro, J., Thompson, Y., Holgado, B. L., Reimand, J., Ke, S. Q., Tropper, A., Lai, S., Vijayarajah, S., Doan, S., Mahadev, V., Miñan, A. F., Gröbner, S. N., Lienhard, M., Zapatka, M., Huang, Z., Aldape, K. D., Carcaboso, A. M., Houghton, P. J., Keir, S. T., Milde, T., Witt, H., Li, Y., Li, C. J., Bian, X. W., Jones, D. T. W., Scott, I., Singh, S. K., Huang, A., Dirks, P. B., Bouffet, E., Bradner, J. E., Ramaswamy, V., Jabado, N., Rutka, J. T., Northcott, P. A., Lupien, M., Lichter, P., Korshunov, A., Scacheri, P. C., Pfister, S. M., Kool, M., Taylor, M. D. & Rich, J. N., Jan 4 2018, In : Nature. 553, 7686, p. 101-105 5 p.

Research output: Contribution to journalArticle

56 Scopus citations
2017

Bioluminescence imaging enhances analysis of drug responses in a patient-derived xenograft model of pediatric ALL

Jones, L., Richmond, J., Evans, K., Carol, H., Jing, D., Kurmasheva, R. T., Billups, C. A., Houghton, P. J., Smith, M. A. & Lock, R. B., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3744-3755 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Evaluation of the selectivity and sensitivity of isoform-And mutation-specific RAS antibodies

Waters, A. M., Ozkan-Dagliyan, I., Vaseva, A. V., Fer, N., Strathern, L. A., Hobbs, G. A., Tessier-Cloutier, B., Gillette, W. K., Bagni, R., Whiteley, G. R., Hartley, J. L., Mccormick, F., Cox, A. D., Houghton, P. J., Huntsman, D. G., Philips, M. R. & Der, C. J., Sep 26 2017, In : Science Signaling. 10, 498, eaao3332.

Research output: Contribution to journalArticle

20 Scopus citations

EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1

Jayabal, P., Houghton, P. J. & Shiio, Y., Nov 2017, In : Genes and Cancer. 8, 11-12, p. 762-770 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program

Kurmasheva, R. T., Sammons, M., Favours, E., Wu, J., Kurmashev, D., Cosmopoulos, K., Keilhack, H., Klaus, C. R., Houghton, P. J. & Smith, M. A., Mar 1 2017, In : Pediatric Blood and Cancer. 64, 3, e26218.

Research output: Contribution to journalArticle

37 Scopus citations

Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program

Lock, R., Carol, H., Maris, J. M., Kolb, E. A., Gorlick, R., Reynolds, C. P., Kang, M. H., Keir, S. T., Wu, J., Purmal, A., Gudkov, A., Kurmashev, D., Kurmasheva, R. T., Houghton, P. J. & Smith, M. A., Apr 1 2017, In : Pediatric Blood and Cancer. 64, 4, e26263.

Research output: Contribution to journalArticle

5 Scopus citations

Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program

Kurmasheva, R. T., Gorlick, R., Kolb, E. A., Keir, S. T., Maris, J. M., Lock, R. B., Carol, H., Kang, M., Reynolds, C. P., Wu, J., Houghton, P. J. & Smith, M. A., Apr 1 2017, In : Pediatric Blood and Cancer. 64, 4, e26304.

Research output: Contribution to journalArticle

4 Scopus citations

P53 suppresses ribonucleotide reductase via inhibiting mTORC1

He, Z., Hu, X., Liu, W., Dorrance, A., Garzon, R., Houghton, P. J. & Shen, C., 2017, In : Oncotarget. 8, 25, p. 41422-41431 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

PDX-MI: Minimal information for patient-derived tumor xenograft models

Meehan, T. F., Conte, N., Goldstein, T., Inghirami, G., Murakami, M. A., Brabetz, S., Gu, Z., Wiser, J. A., Dunn, P., Begley, D. A., Krupke, D. M., Bertotti, A., Bruna, A., Brush, M. H., Byrne, A. T., Caldas, C., Christie, A. L., Clark, D. A., Dowst, H., Dry, J. R. & 34 others, Doroshow, J. H., Duchamp, O., Evrard, Y. A., Ferretti, S., Frese, K. K., Goodwin, N. C., Greenawalt, D., Haendel, M. A., Hermans, E., Houghton, P. J., Jonkers, J., Kemper, K., Khor, T. O., Lewis, M. T., Lloyd, K. C. K., Mason, J., Medico, E., Neuhauser, S. B., Olson, J. M., Peeper, D. S., Rueda, O. M., Seong, J. K., Trusolino, L., Vinolo, E., Wechsler-Reya, R. J., Weinstock, D. M., Welm, A., Weroha, S. J., Amant, F., Pfister, S. M., Kool, M., Parkinson, H., Butte, A. J. & Bult, C. J., Nov 1 2017, In : Cancer Research. 77, 21, p. e62-e66

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells

Zhou, X., Liu, W., Hu, X., Dorrance, A., Garzon, R., Houghton, P. J. & Shen, C., Dec 1 2017, In : Scientific Reports. 7, 1, 1535.

Research output: Contribution to journalArticle

14 Scopus citations

Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing’s sarcoma, and rhabdomyosarcoma

Yu, P. Y., Gardner, H. L., Roberts, R., Cam, H., Hariharan, S., Ren, L., Leblanc, A. K., Xiao, H., Lin, J., Guttridge, D. C., Mo, X., Bennett, C. E., Coss, C. C., Ling, Y., Phelps, M. A., Houghton, P. & London, C. A., Jul 2017, In : PloS one. 12, 7, e0181885.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant

Richmond, J., Robbins, A., Evans, K., Beck, D., Kurmasheva, R. T., Billups, C. A., Carol, H., Heatley, S., Sutton, R., Marshall, G. M., White, D., Pimanda, J., Houghton, P. J., Smith, M. A. & Lock, R. B., Aug 1 2016, In : Cancer Research. 76, 15, p. 4579-4591 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program

Jones, L., Carol, H., Evans, K., Richmond, J., Houghton, P. J., Smith, M. A. & Lock, R. B., Nov 1 2016, In : Leukemia. 30, 11, p. 2133-2141 9 p.

Research output: Contribution to journalReview article

27 Scopus citations

Evaluation of alternative in vivo drug screening methodology: A single mouse analysis

Murphy, B., Yin, H., Maris, J. M., Kolb, E. A., Gorlick, R., Reynolds, C. P., Kang, M. H., Keir, S. T., Kurmasheva, R. T., Dvorchik, I., Wu, J., Billups, C. A., Boateng, N., Smith, M. A., Lock, R. B. & Houghton, P. J., Oct 1 2016, In : Cancer Research. 76, 19, p. 5798-5809 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hypoxic proliferation of osteosarcoma cells depends on arginase II

Setty, B. A., Jin, Y., Houghton, P. J., Yeager, N. D., Gross, T. G. & Nelin, L. D., Jul 1 2016, In : Cellular Physiology and Biochemistry. 39, 2, p. 802-813 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identifying novel therapeutic agents using xenograft models of pediatric cancer

Kurmasheva, R. T. & Houghton, P. J., Aug 1 2016, In : Cancer Chemotherapy and Pharmacology. 78, 2, p. 221-232 12 p.

Research output: Contribution to journalReview article

7 Scopus citations

Initial Testing (Stage 1) of MK-8242—A Novel MDM2 Inhibitor—by the Pediatric Preclinical Testing Program

Kang, M. H., Reynolds, C. P., Kolb, E. A., Gorlick, R., Carol, H., Lock, R., Keir, S. T., Maris, J. M., Wu, J., Lyalin, D., Kurmasheva, R. T., Houghton, P. J. & Smith, M. A., Oct 1 2016, In : Pediatric Blood and Cancer. 63, 10, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program

Gorlick, R., Kolb, E. A., Keir, S. T., Maris, J. M., Lock, R. B., Carol, H., Reynolds, C. P., Kang, M. H., Billups, C. A., Collins, J., Kurmashev, D., Kurmasheva, R. T., Houghton, P. J. & Smith, M. A., Mar 1 2016, In : Pediatric Blood and Cancer. 63, 3, p. 443-450 8 p.

Research output: Contribution to journalArticle

Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program

Attiyeh, E. F., Maris, J. M., Lock, R., Reynolds, C. P., Kang, M. H., Carol, H., Gorlick, R., Kolb, E. A., Keir, S. T., Wu, J., Landesman, Y., Shacham, S., Lyalin, D., Kurmasheva, R. T., Houghton, P. J. & Smith, M. A., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 276-286 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia

Dolai, S., Sia, K. C. S., Robbins, A. K., Zhong, L., Heatley, S. L., Vincent, T. L., Hochgräfe, F., Sutton, R., Kurmasheva, R. T., Revesz, T., White, D. L., Houghton, P. J., Smith, M. A., Teachey, D. T., Daly, R. J., Raftery, M. J. & Lock, R. B., May 1 2016, In : Cancer Research. 76, 9, p. 2766-2777 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Targeting Glycoprotein NMB With Antibody-Drug Conjugate, Glembatumumab Vedotin, for the Treatment of Osteosarcoma

Roth, M., Barris, D. M., Piperdi, S., Kuo, V., Everts, S., Geller, D., Houghton, P., Kolb, E. A., Hawthorne, T., Gill, J. & Gorlick, R., Jan 1 2016, In : Pediatric Blood and Cancer. 63, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

26 Scopus citations