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  • Patrick M Sung

Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination

Crickard, J. B., Moevus, C. J., Kwon, Y., Sung, P. & Greene, E. C., Jun 11 2020, In : Cell. 181, 6, p. 1380-1394.e18

Research output: Contribution to journalArticle

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

Daley, J. M., Tomimatsu, N., Hooks, G., Wang, W., Miller, A. S., Xue, X., Nguyen, K. A., Kaur, H., Williamson, E., Mukherjee, B., Hromas, R., Burma, S. & Sung, P., Dec 1 2020, In : Nature communications. 11, 1, 3088.

Research output: Contribution to journalArticle

Open Access

The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

Tarsounas, M. & Sung, P., May 1 2020, In : Nature Reviews Molecular Cell Biology. 21, 5, p. 284-299 16 p.

Research output: Contribution to journalReview article

1 Scopus citations

The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair

Liang, F., Miller, A. S., Tang, C., Maranon, D., Williamson, E. A., Hromas, R. A., Wiese, C., Zhao, W., Sung, P. & Kupfer, G. M., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8186-8194 9 p.

Research output: Contribution to journalArticle

The splicing component ISY1 regulates APE1 in base excision repair

Jaiswal, A. S., Williamson, E. A., Srinivasan, G., Kong, K., Lomelino, C. L., McKenna, R., Walter, C., Sung, P., Narayan, S. & Hromas, R., Feb 2020, In : DNA Repair. 86, 102769.

Research output: Contribution to journalArticle

Open Access

The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, S., Simonsen, A. K. W., Viswalingam, K. S., Gonzalez, L., Hickson, I. D., Oestergaard, V. H., Mankouri, H. W., Sung, P. & Lisby, M., Jul 7 2020, In : Cell Reports. 32, 1, 107849.

Research output: Contribution to journalArticle

Open Access

UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide

Pérez-Calero, C., Bayona-Feliu, A., Xue, X., Barroso, S. I., Muñoz, S., González-Basallote, V. M., Sung, P. & Aguilera, A., Jul 1 2020, In : Genes & development. 34, 13-14, p. 898-912 15 p.

Research output: Contribution to journalArticle

Open Access
2019

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Liang, Z., Liang, F., Teng, Y., Chen, X., Liu, J., Longerich, S., Rao, T., Green, A. M., Collins, N. B., Xiong, Y., Lan, L., Sung, P. & Kupfer, G. M., Jan 15 2019, In : Cell Reports. 26, 3, p. 564-572.e5

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

Bai, Y., Wang, W., Li, S., Zhan, J., Li, H., Zhao, M., Zhou, X. A., Li, S., Li, X., Huo, Y., Shen, Q., Zhou, M., Zhang, H., Luo, J., Sung, P., Zhu, W. G., Xu, X. & Wang, J., Sep 19 2019, In : Molecular Cell. 75, 6, p. 1299-1314.e6

Research output: Contribution to journalArticle

1 Scopus citations

Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

Jiang, H., Xue, X., Panda, S., Kawale, A., Hooy, R. M., Liang, F., Sohn, J., Sung, P. & Gekara, N. O., Oct 4 2019, In : EMBO Journal. 38, 21, e102718.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts

Biswas, H., Goto, G., Wang, W., Sung, P. & Sugimoto, K., 2019, In : PLoS Genetics. 15, 8, e1008294.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination

Steinfeld, J. B., Beláň, O., Kwon, Y., Terakawa, T., Al-Zain, A., Smith, M. J., Crickard, J. B., Qi, Z., Zhao, W., Rothstein, R., Symington, L. S., Sung, P., Boulton, S. J. & Greene, E. C., Sep 1 2019, In : Genes and Development. 33, 17-18, p. 1191-1207 17 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

Liang, F., Miller, A. S., Longerich, S., Tang, C., Maranon, D., Williamson, E. A., Hromas, R., Wiese, C., Kupfer, G. M. & Sung, P., Dec 1 2019, In : Nature communications. 10, 1, 2849.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
6 Scopus citations

Fanconi anemia protein FANCI functions in ribosome biogenesis

Sondalle, S. B., Longerich, S., Ogawa, L. M., Sung, P. & Baserga, S. J., Feb 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 7, p. 2561-2570 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Klein, H. L., Ang, K. K. H., Arkin, M. R., Beckwitt, E. C., Chang, Y. H., Fan, J., Kwon, Y., Morten, M. J., Mukherjee, S., Pambos, O. J., Sayyed, H. E., Thrall, E. S., Vieira-Da-Rocha, J. P., Wang, Q., Wang, S., Yeh, H. Y., Biteen, J. S., Chi, P., Heyer, W. D., Kapanidis, A. N. & 6 others, Loparo, J. J., Strick, T. R., Sung, P., Van Houten, B., Niu, H. & Rothenberg, E., Jan 2019, In : Microbial Cell. 6, 1, p. 65-101 37 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers

Srinivasan, G., Williamson, E. A., Kong, K., Jaiswal, A. S., Huang, G., Kim, H. S., Schärer, O., Zhao, W., Burma, S., Sung, P. & Hromas, R., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17438-17443 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast

Yan, Z., Xue, C., Kumar, S., Crickard, J. B., Yu, Y., Wang, W., Pham, N., Li, Y., Niu, H., Sung, P., Greene, E. C. & Ira, G., Dec 5 2019, In : Molecular Cell. 76, 5, p. 699-711.e6

Research output: Contribution to journalArticle

2 Scopus citations

Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection

Xue, C., Wang, W., Crickard, J. B., Moevus, C. J., Kwon, Y., Sung, P. & Greene, E. C., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6091-6100 10 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates

Xue, C., Daley, J. M., Xue, X., Steinfeld, J., Kwon, Y., Sung, P. & Greene, E. C., Dec 2 2019, In : Nucleic acids research. 47, 21, p. 11225-11237 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The BRCA tumor suppressor network in chromosome damage repair by homologous recombination

Zhao, W., Wiese, C., Kwon, Y., Hromas, R. & Sung, P., Jun 20 2019, In : Annual Review of Biochemistry. 88, p. 221-245 25 p.

Research output: Contribution to journalReview article

11 Scopus citations

The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers

Marzio, A., Puccini, J., Kwon, Y., Maverakis, N. K., Arbini, A., Sung, P., Bar-Sagi, D. & Pagano, M., Jan 17 2019, In : Molecular Cell. 73, 2, p. 224-237.e6

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway

Rosenbaum, J. C., Bonilla, B., Hengel, S. R., Mertz, T. M., Herken, B. W., Kazemier, H. G., Pressimone, C. A., Ratterman, T. C., MacNary, E., De Magis, A., Kwon, Y., Godin, S. K., Van Houten, B., Normolle, D. P., Sung, P., Das, S. R., Paeschke, K., Roberts, S. A., VanDemark, A. P. & Bernstein, K. A., Dec 1 2019, In : Nature communications. 10, 1, 3515.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments

Crickard, J. B., Xue, C., Wang, W., Kwon, Y., Sung, P. & Greene, E. C., 2019, In : Nucleic acids research. 47, 9, p. 4694-4706 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1–Dna2 in long-range DNA end resection

Wang, W., Daley, J. M., Kwon, Y., Xue, X., Krasner, D. S., Miller, A. S., Nguyen, K. A., Williamson, E. A., Shim, E. Y., Lee, S. E., Hromas, R. & Sung, P., Nov 2 2018, In : Journal of Biological Chemistry. 293, 44, p. 17061-17069 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Determining the RAD51-DNA Nucleoprotein Filament Structure and Function by Cryo-Electron Microscopy

Zhao, L., Xu, J., Zhao, W., Sung, P. & Wang, H. W., Jan 1 2018, Methods in Enzymology. Academic Press Inc., p. 179-199 21 p. (Methods in Enzymology; vol. 600).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage

Rao, T., Longerich, S., Zhao, W., Aihara, H., Sung, P. & Xiong, Y., Apr 2018, In : DNA Repair. 64, p. 53-58 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Introduction to the thematic minireview series: DNA double-strand break repair and pathway choice

Sung, P., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10500-10501 2 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations

Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase

Crickarda, J. B., Kaniecki, K., Kwon, Y., Sung, P. & Greene, E. C., Oct 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10041-E10048

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection

Cheng, X., Jobin-Robitaille, O., Billon, P., Buisson, R., Niu, H., Lacoste, N., Abshiru, N., Côté, V., Thibault, P., Kron, S. J., Sung, P., Brandl, C. J., Masson, J. Y. & Côté, J., Oct 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 10028-10033 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Regulation of Hed1 and Rad54 binding during maturation of the meiosis-specific presynaptic complex

Crickard, J. B., Kaniecki, K., Kwon, Y. H., Sung, P., Lisby, M. & Greene, E. C., Apr 3 2018, In : EMBO Journal. 37, 7, e98728.

Research output: Contribution to journalArticle

9 Scopus citations

Spontaneous self-segregation of Rad51 and Dmc1 DNA recombinases within mixed recombinase filaments

Brooks Crickard, J., Kaniecki, K., Kwon, Y., Sung, P. & Greene, E. C., Mar 16 2018, In : Journal of Biological Chemistry. 293, 11, p. 4191-4200 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance

Cassani, C., Gobbini, E., Vertemara, J., Wang, W., Marsella, A., Sung, P., Tisi, R., Zampella, G. & Longhese, M. P., 2018, In : Nucleic acids research. 46, 6, p. 2990-3008 19 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

The MRX complex regulates Exo1 resection activity by altering DNA end structure

Gobbini, E., Cassani, C., Vertemara, J., Wang, W., Mambretti, F., Casari, E., Sung, P., Tisi, R., Zampella, G. & Longhese, M. P., Aug 15 2018, In : EMBO Journal. 37, 16, e98588.

Research output: Contribution to journalArticle

11 Scopus citations
2017

A novel role of the Dna2 translocase function in DNA break resection

Miller, A. S., Daley, J. M., Pham, N. T., Niu, H., Xue, X., Ira, G. & Sung, P., Mar 1 2017, In : Genes and Development. 31, 5, p. 503-510 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing

Zhao, W., Steinfeld, J. B., Liang, F., Chen, X., Maranon, D. G., Jian Ma, C., Kwon, Y., Rao, T., Wang, W., Sheng, C., Song, X., Deng, Y., Jimenez-Sainz, J., Lu, L., Jensen, R. B., Xiong, Y., Kupfer, G. M., Wiese, C., Greene, E. C. & Sung, P., Oct 19 2017, In : Nature. 550, 7676, nature24060.

Research output: Contribution to journalArticle

73 Scopus citations
Open Access

Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange

Xu, J., Zhao, L., Xu, Y., Zhao, W., Sung, P. & Wang, H. W., Jan 5 2017, In : Nature Structural and Molecular Biology. 24, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2

Kaniecki, K., De Tullio, L., Gibb, B., Kwon, Y., Sung, P. & Greene, E. C., Dec 12 2017, In : Cell Reports. 21, 11, p. 3166-3177 12 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

Daley, J. M., Jimenez-Sainz, J., Wang, W., Miller, A. S., Xue, X., Nguyen, K. A., Jensen, R. B. & Sung, P., Oct 10 2017, In : Cell Reports. 21, 2, p. 324-332 9 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Human DNA polymerase η accommodates RNA for strand extension

Su, Y., Egli, M., Guengerich, F. P. & Sung, P., Nov 3 2017, In : Journal of Biological Chemistry. 292, 44, p. 18044-18051 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Human RAD52 interactions with replication protein a and the RAD51 presynaptic complex

Ma, C. J., Kwon, Y., Sung, P. & Greene, E. C., Jul 14 2017, In : Journal of Biological Chemistry. 292, 28, p. 11702-11713 12 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

Kumar, S., Peng, X., Daley, J., Yang, L., Shen, J., Nguyen, N., Bae, G., Niu, H., Peng, Y., Hsieh, H. J., Wang, L., Rao, C., Stephan, C. C., Sung, P., Ira, G. & Peng, G., Apr 17 2017, In : Oncogenesis. 6, 4, e319.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Nucleosome-like, single-stranded DNA (ssDNA)-histone octamer complexes and the implication for DNA double strand break repair

Adkins, N. L., Swygert, S. G., Kaur, P., Niu, H., Grigoryev, S. A., Sung, P., Wang, H. & Peterson, C. L., Mar 31 2017, In : Journal of Biological Chemistry. 292, 13, p. 5271-5281 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles

Wang, W., Daley, J. M., Kwon, Y., Krasner, D. S. & Sung, P., Dec 1 2017, In : Genes and Development. 31, 23-24, p. 2331-2336 6 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

Ma, C. J., Gibb, B., Kwon, Y., Sung, P. & Greene, E. C., Jan 1 2017, In : Nucleic acids research. 45, 2, p. 749-761 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Rad52, Maestro of Inverse Strand Exchange

Kwon, Y. & Sung, P., Jul 6 2017, In : Molecular Cell. 67, 1, p. 1-3 3 p.

Research output: Contribution to journalShort survey

Open Access
1 Scopus citations

Reconstituted System for the Examination of Repair DNA Synthesis in Homologous Recombination

Kwon, Y., Daley, J. M. & Sung, P., Jan 1 2017, Methods in Enzymology. Academic Press Inc., p. 307-325 19 p. (Methods in Enzymology; vol. 591).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis

Pires, E., Sung, P. & Wiese, C., Nov 2017, In : DNA Repair. 59, p. 76-81 6 p.

Research output: Contribution to journalReview article

5 Scopus citations