Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Guangming Zhong
2020

Chlamydia deficient in plasmid-encoded pgp3 is prevented from spreading to large intestine

Huo, Z., He, C., Xu, Y., Jia, T., Wang, J. & Zhong, G., Jun 1 2020, In : Infection and immunity. 88, 6, e00120.

Research output: Contribution to journalArticle

Evasion of innate lymphoid cell-regulated gamma interferon responses by chlamydia muridarum to achieve long-lasting colonization in mouse colon

Koprivsek, J. J., He, Y., Song, C., Zhang, N., Tumanov, A. & Zhong, G., Mar 1 2020, In : Infection and immunity. 88, 3, e00798-19.

Research output: Contribution to journalArticle

1 Scopus citations

Gastrointestinal coinfection promotes chlamydial pathogenicity in the genital tract

Tian, Q., Zhou, Z., Wang, L., Abu-Khdeir, A. M. H., Huo, Z., Sun, X., Zhang, N., Schenken, R., Wang, Y., Xue, M. & Zhong, G., Mar 1 2020, In : Infection and immunity. 88, 4, e00905-19.

Research output: Contribution to journalArticle

Proteome array of antibody responses to Chlamydia trachomatis infection in nonhuman primates

Lu, C., Sun, Z., Chen, H., Chen, L., Zhu, C., Chen, C., Li, C., Peng, B. & Zhong, G., May 1 2020, In : Life Sciences. 248, 117444.

Research output: Contribution to journalArticle

The cryptic plasmid improves chlamydia fitness in different regions of the gastrointestinal tract

Ma, J., He, C., Huo, Z., Xu, Y., Arulanandam, B., Liu, Q. & Zhong, G., Mar 1 2020, In : Infection and immunity. 88, 3, e00860-19.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Antigen-specific CD4 T cell-derived gamma interferon is both necessary and sufficient for clearing chlamydia from the small intestine but not the large intestine

Lin, H., He, C., Koprivsek, J. J., Chen, J., Zhou, Z., Arulanandam, B., Xu, Z., Tang, L. & Zhong, G., Jan 1 2019, In : Infection and Immunity. 87, 6, e00055-19.

Research output: Contribution to journalArticle

3 Scopus citations

A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains

Zhou, Z., Liu, N., Wang, Y., Emmanuel, A. W., You, X., Liu, J., Li, Z., Wu, Y. & Zhong, G., Apr 1 2019, In : Pathogens and disease. 77, 3, ftz017.

Research output: Contribution to journalArticle

Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune response

Hou, S., Sun, X., Dong, X., Lin, H., Tang, L., Xue, M. & Zhong, G., Jan 1 2019, In : Microbes and Infection. 21, 1, p. 50-55 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Chlamydia muridarum induces pathology in the female upper genital tract via distinct mechanisms

Yu, H., Lin, H., Xie, L., Tang, L., Chen, J., Zhou, Z., Ni, J. & Zhong, G., Jan 1 2019, In : Infection and immunity. 87, 8, e00145.

Research output: Contribution to journalArticle

2 Scopus citations

Distinct roles of chromosome- versus plasmid-encoded genital tract virulence factors in promoting chlamydia muridarum colonization in the gastrointestinal tract

Koprivsek, J. J., Zhang, T., Tian, Q., He, Y., Xu, H., Xu, Z. & Zhong, G., Jan 1 2019, In : Infection and immunity. 87, 8, e00265.

Research output: Contribution to journalArticle

4 Scopus citations

IL-10通过抑制IFN-γ和IL-2表达促进鼠衣原体感染

Translated title of the contribution: IL-10 promotes Chlamydia muridarum infection in mice through inhibiting IFN-γ and IL-2 expressionHe, Q., He, M., Wang, X., Luo, X., Wu, Y. & Zhong, G., Feb 28 2019, In : Chinese Journal of Microbiology and Immunology (China). 39, 2, p. 126-130 5 p.

Research output: Contribution to journalArticle

The plasmid-encoded PGP3 promotes chlamydia evasion of acidic barriers in both stomach and vagina

Zhang, T., Huo, Z., Ma, J., He, C. & Zhong, G., May 1 2019, In : Infection and Immunity. 87, 5, e00844-18.

Research output: Contribution to journalArticle

7 Scopus citations

TIM-4 inhibits NLRP3 inflammasome via the LKB1/AMPKA pathway in macrophages

Liu, W., Bai, F., Wang, H., Liang, Y., Du, X., Liu, C., Cai, D., Peng, J., Zhong, G., Liang, X., Ma, C. & Gao, L., Aug 15 2019, In : Journal of Immunology. 203, 4, p. 990-1000 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

2017: beginning of a new era for Chlamydia research in China and the rest of the world

Fan, H. & Zhong, G., Jan 2018, In : Microbes and Infection. 20, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

Advances and obstacles in the genetic dissection of chlamydial virulence

Brothwell, J. A., Muramatsu, M. K., Zhong, G. & Nelson, D. E., Jan 1 2018, Current Topics in Microbiology and Immunology. Springer Verlag, p. 133-158 26 p. (Current Topics in Microbiology and Immunology; vol. 412).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Nonpathogenic colonization with Chlamydia in the gastrointestinal tract as oral vaccination for inducing transmucosal protection

Wang, L., Zhu, C., Zhang, T., Tian, Q., Zhang, N., Morrison, S., Morrison, R., Xue, M. & Zhong, G., Feb 1 2018, In : Infection and Immunity. 86, 2, e00630-17.

Research output: Contribution to journalArticle

10 Scopus citations

Oral Chlamydia vaccination induces transmucosal protection in the airway

Zhu, C., Lin, H., Tang, L., Chen, J., Wu, Y. & Zhong, G., Apr 12 2018, In : Vaccine. 36, 16, p. 2061-2068 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract

Shao, L., Zhang, T., Melero, J., Huang, Y., Liu, Y., Liu, Q., He, C., Nelson, D. E. & Zhong, G., Jan 1 2018, In : Infection and Immunity. 86, 1, e00429-17.

Research output: Contribution to journalArticle

12 Scopus citations

Transcervical inoculation with Chlamydia trachomatis induces infertility in HLA-DR4 transgenic and wild-type mice

Pal, S., Tifrea, D. F., Zhong, G. & de la Maza, L. M., Jan 1 2018, In : Infection and Immunity. 86, 1, e00722-17.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Chlamydial lipoproteins stimulate toll-like receptors 1/2 mediated inflammatory responses through MyD88-dependent pathway

Wang, Y., Liu, Q., Chen, D., Guan, J., Ma, L., Zhong, G., Shu, H. & Wu, X., Jan 26 2017, In : Frontiers in Microbiology. 8, JAN, 78.

Research output: Contribution to journalArticle

10 Scopus citations

Chlamydial protease-like activity factor mediated protection against C. trachomatis in guinea pigs

Wali, S., Gupta, R., Yu, J. J., Lanka, G. K. K., Chambers, J. P., Guentzel, M. N., Zhong, G., Murthy, A. K. & Arulanandam, B. P., May 1 2017, In : Immunology and Cell Biology. 95, 5, p. 454-460 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chlamydia muridarum with mutations in chromosomal genes tc0237 and/or tc0668 is deficient in colonizing the mouse gastrointestinal tract

Shao, L., Zhang, T., Liu, Q., Wang, J. & Zhong, G., Aug 1 2017, In : Infection and Immunity. 85, 8, e00321-17.

Research output: Contribution to journalArticle

15 Scopus citations

Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis

Zhong, G., Jan 1 2017, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

13 Scopus citations

CPAF selectively degrades chlamydial T cell antigens for inhibiting antigen presentation

Zhang, Y., Zhong, G., Cai, H., Chen, S., Sun, D., Zhang, D. & He, Y., Nov 1 2017, In : Journal of Infection in Developing Countries. 11, 11, p. 868-875 8 p.

Research output: Contribution to journalArticle

IL-6-mediated signaling pathways limit Chlamydia muridarum infection and exacerbate its pathogenicity in the mouse genital tract

Sun, X., Tian, Q., Wang, L., Xue, M. & Zhong, G., Nov 1 2017, In : Microbes and Infection. 19, 11, p. 536-545 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

National institute of allergy and infectious diseases workshop report: “Chlamydia vaccines: The way forward“

Zhong, G., Brunham, R. C., de la Maza, L. M., Darville, T. & Deal, C., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

10 Scopus citations

The cryptic plasmid is more important for Chlamydia muridarum to colonize the mouse gastrointestinal tract than to infect the genital tract

Shao, L., Melero, J., Zhang, N., Arulanandam, B., Baseman, J., Liu, Q. & Zhong, G., May 1 2017, In : PLoS One. 12, 5, e0177691.

Research output: Contribution to journalArticle

15 Scopus citations

Update on Chlamydia trachomatis vaccinology

De La Maza, L. M., Zhong, G. & Brunham, R. C., Apr 2017, In : Clinical and Vaccine Immunology. 24, 4, 0054316.

Research output: Contribution to journalReview article

34 Scopus citations

Uterotubal junction prevents chlamydial ascension via innate immunity

Zhang, Y., Shao, L., Li, X. & Zhong, G., Aug 2017, In : PloS one. 12, 8, e0183189.

Research output: Contribution to journalArticle

2 Scopus citations
2016

An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions

Dutow, P., Wask, L., Bothe, M., Fehlhaber, B., Laudeley, R., Rheinheimer, C., Yang, Z., Zhong, G., Glage, S. & Klos, A., Mar 1 2016, In : Pathogens and Disease. 74, 2

Research output: Contribution to journalArticle

3 Scopus citations

Chlamydial Plasmid-Dependent Pathogenicity

Zhong, G., 2016, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

37 Scopus citations

Guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16:0/18:1 and contribution to Chlamydia trachomatis serovar D infectivity

Wali, S., Gupta, R., Yu, J. J., Mfuh, A., Gao, X., Guentzel, M. N., Chambers, J. P., Bakar, S. A., Zhong, G. & Arulanandam, B. P., Apr 1 2016, In : Metabolomics. 12, 4, 74.

Research output: Contribution to journalArticle

2 Scopus citations

IgA modulates respiratory dysfunction as a sequela to pulmonary chlamydial infection as neonates

Lanka, G. K. K., Yu, J. J., Gong, S., Gupta, R., Mustafa, S. B., Murthy, A. K., Zhong, G., Chambers, J. P., Guentzel, M. N. & Arulanandam, B. P., Apr 1 2016, In : Pathogens and Disease. 74, 3

Research output: Contribution to journalArticle

2 Scopus citations

Intravenous inoculation with chlamydia muridarum leads to a long-lasting infection restricted to the gastrointestinal tract

Dai, J., Zhang, T., Wang, L., Shao, L., Zhu, C., Zhang, Y., Failor, C., Schenken, R. S., Baseman, J., He, C. & Zhong, G., 2016, In : Infection and Immunity. 84, 8, p. 2382-2388 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF

Yang, Z., Tang, L., Zhou, Z. & Zhong, G., Nov 1 2016, In : Microbes and Infection. 18, 11, p. 669-674 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Small molecule inhibition of Rab7 impairs B cell class switching and plasma cell survival to dampen the autoantibody response in murine lupus

Lam, T., Kulp, D. V., Wang, R., Lou, Z., Taylor, J., Rivera, C. E., Yan, H., Zhang, Q., Wang, Z., Zan, H., Ivanov, D. N., Zhong, G., Casali, P. & Xu, Z., Nov 15 2016, In : Journal of Immunology. 197, 10, p. 3792-3805 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Chlamydia muridarum organisms fail to auto-inoculate the mouse genital tract after colonization in the gastrointestinal tract for 70 days

Wang, L., Zhang, Q., Zhang, T., Zhang, Y., Zhu, C., Sun, X., Zhang, N., Xue, M. & Zhong, G., May 1 2016, In : PLoS One. 11, 5, e0155880.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection

Yang, Z., Tang, L., Sun, X., Chai, J. & Zhong, G., 2015, In : Infection and immunity. 83, 6, p. 2234-2241 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37

Hou, S., Dong, X., Yang, Z., Li, Z., Liu, Q. & Zhong, G., 2015, In : Infection and Immunity. 83, 12, p. 4701-4709 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Chlamydia muridarum induction of glandular duct dilation in mice

Sun, X., Yang, Z., Zhang, H., Dai, J., Chen, J., Tang, L., Rippentrop, S., Xue, M., Zhong, G. & Wu, G., Jan 1 2015, In : Infection and immunity. 83, 6, p. 2327-2337 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chlamydia-secreted protease CPAF degrades host antimicrobial peptides

Tang, L., Chen, J., Zhou, Z., Yu, P., Yang, Z. & Zhong, G., 2015, In : Microbes and Infection. 17, 6, p. 402-408 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effect of pH on cleavage of glycogen by vaginal enzymes

Spear, G. T., McKenna, M., Landay, A. L., Makinde, H., Hamaker, B., French, A. L., Lee, B. H. & Zhong, G., Jul 14 2015, In : PLoS One. 10, 7

Research output: Contribution to journalArticle

15 Scopus citations

Identification of plasmid-free chlamydia muridarum organisms using a pgp3 detection-based immunofluorescence assay

Chen, C., Zhong, G., Ren, L., Lu, C., Li, Z. & Wu, Y., Jan 1 2015, In : Journal of Microbiology and Biotechnology. 25, 10, p. 1621-1628 8 p., A006.

Research output: Contribution to journalArticle

3 Scopus citations

Infection with Chlamydia pneumoniae as a cause of coronary heart disease: The hypothesis is still untested

Grayston, J. T., Belland, R. J., Byrne, G. I., Kuo, C. C., Schachter, J., Stamm, W. E. & Zhong, G., Jan 1 2015, In : Pathogens and disease. 73, 1, ftu015.

Research output: Contribution to journalComment/debate

18 Scopus citations

Intrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating plasmid-independent pathogenicity

Chen, J., Yang, Z., Sun, X., Tang, L., Ding, Y., Xue, M., Zhou, Z., Baseman, J. & Zhong, G., Jan 1 2015, In : Infection and immunity. 83, 6, p. 2583-2592 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract

Chen, C., Zhou, Z., Conrad, T., Yang, Z., Dai, J., Li, Z., Wu, Y. & Zhong, G., Jan 1 2015, In : Infection and Immunity. 83, 5, p. 1881-1892 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

In vivo and ex vivo imaging reveals a long-lasting chlamydial infection in the mouse gastrointestinal tract following genital tract inoculation

Zhang, Q., Huang, Y., Gong, S., Yang, Z., Sun, X., Schenken, R. S. & Zhong, G., 2015, In : Infection and Immunity. 83, 9, p. 3568-3577 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Plasmid-encoded Pgp5 is a significant contributor to Chlamydia muridarum induction of hydrosalpinx

Huang, Y., Zhang, Q., Yang, Z., Conrad, T., Liu, Y. & Zhong, G., Apr 27 2015, In : PloS one. 10, 4, e0124840.

Research output: Contribution to journalArticle

21 Scopus citations
7 Scopus citations

The chromosome-encoded hypothetical protein TC0668 is an upper genital tract pathogenicity factor of Chlamydia muridarum

Conrad, T. A., Gong, S., Yang, Z., Matulich, P., Keck, J., Beltrami, N., Chen, C., Zhou, Z., Dai, J. & Zhong, G., 2015, In : Infection and Immunity. 84, 2, p. 467-479 13 p.

Research output: Contribution to journalArticle

27 Scopus citations