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Author

  • Martin G Schwacha
2020

The gut microbiome distinguishes mortality in trauma patients upon admission to the emergency department

Burmeister, D. M., Johnson, T. R., Lai, Z., Scroggins, S. R., DeRosa, M., Jonas, R. B., Zhu, C., Scherer, E., Stewart, R. M., Schwacha, M. G., Jenkins, D. H., Eastridge, B. J. & Nicholson, S. E., May 1 2020, In : The journal of trauma and acute care surgery. 88, 5, p. 579-587 9 p.

Research output: Contribution to journalArticle

Open Access
2019

A prospective study in severely injured patients reveals an altered gut microbiome is associated with transfusion volume

Nicholson, S. E., Burmeister, D. M., Johnson, T. R., Zou, Y., Lai, Z., Scroggins, S., Derosa, M., Jonas, R. B., Merrill, D. R., Zhu, C., Newton, L. M., Stewart, R. M., Schwacha, M. G., Jenkins, D. H. & Eastridge, B. J., Apr 1 2019, In : Journal of Trauma and Acute Care Surgery. 86, 4, p. 573-581 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Burn injury is associated with an infiltration of the wound site with myeloid-derived suppressor cells

Schwacha, M. G., Scroggins, S. R., Montgomery, R. K., Nicholson, S. E. & Cap, A. P., Apr 2019, In : Cellular Immunology. 338, p. 21-26 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner

Nicholson, S. E., Watts, L. T., Burmeister, D. M., Merrill, D., Scroggins, S., Zou, Y., Lai, Z., Grandhi, R., Lewis, A. M., Newton, L. M., Eastridge, B. J. & Schwacha, M. G., Aug 1 2019, In : Shock. 52, 2, p. 240-248 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2018

Compensatory reserve index: Performance of a novel monitoring technology to identify the bleeding trauma patient

Johnson, M. C., Alarhayem, A., Convertino, V., Carter, R., Chung, K., Stewart, R., Myers, J., Dent, D., Liao, L., Cestero, R., Nicholson, S., Muir, M., Schwacha, M., Wampler, D., DeRosa, M. & Eastridge, B. J., Mar 1 2018, In : Shock. 49, 3, p. 295-300 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunopathological response to severe injury: Platelet activation and the Th-17 immune response

Morris, R. S., Schaffer, B. S., Lundy, J. B., Pidcoke, H. F., Chung, K. K., Darlington, D. N., Cap, A. P. & Schwacha, M. G., Jan 1 2018, In : Blood Coagulation and Fibrinolysis. 29, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome

Nicholson, S. E., Merrill, D., Zhu, C., Burmeister, D. M., Zou, Y., Lai, Z., Darlington, D. N., Lewis, A. M., Newton, L., Scroggins, S., Eastridge, B. J. & Schwacha, M. G., Oct 1 2018, In : American Journal of Surgery. 216, 4, p. 699-705 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

The composition of T-cell subsets are altered in the burn wound early after injury

Rani, M. & Schwacha, M. G., Jun 1 2017, In : PLoS One. 12, 6, e0179015.

Research output: Contribution to journalArticle

6 Scopus citations

Traumatic Hemothorax Blood Contains Elevated Levels of Microparticles that are Prothrombotic but Inhibit Platelet Aggregation

Mitchell, T. A., Herzig, M. C., Fedyk, C. G., Salhanick, M. A., Henderson, A. T., Parida, B. K., Prat, N. J., Dent, D. L., Schwacha, M. G. & Cap, A. P., Jun 1 2017, In : Shock. 47, 6, p. 680-687 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation

Rani, M., Nicholson, S. E., Zhang, Q. & Schwacha, M. G., 2016, (Accepted/In press) In : Burns.

Research output: Contribution to journalArticle

24 Scopus citations

Dermal γδ T-cells can be activated by mitochondrial damage-associated molecular patterns

Schwacha, M. G., Rani, M., Nicholson, S. E., Lewis, A. M., Holloway, T. L., Sordo, S. & Cap, A. P., Jul 2016, In : PloS one. 11, 7, e0158993.

Research output: Contribution to journalArticle

6 Scopus citations

Shed pleural blood from traumatic hemothorax contains elevated levels of pro-inflammatory cytokines

Salhanick, M. A., Sams, V. G., Pidcoke, H. F., Fedyk, C. G., Scherer, M. R., Dubick, M. A., Dent, D. L., Cap, A. P. & Schwacha, M. G., Aug 1 2016, In : Shock. 46, 2, p. 144-148 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Toll-like receptor responses are suppressed in trauma ICU patients

Holloway, T. L., Nicholson, S. E., Rani, M., Cap, A. P. & Schwacha, M. G., Nov 1 2016, In : Journal of Surgical Research. 206, 1, p. 139-145 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tranexamic Acid Attenuates the Loss of Lung Barrier Function in a Rat Model of Polytrauma and Hemorrhage with Resuscitation

Wu, X., Dubick, M. A., Schwacha, M. G., Cap, A. P. & Darlington, D. N., Sep 19 2016, (Accepted/In press) In : Shock.

Research output: Contribution to journalArticle

11 Scopus citations

Trauma-Related Acute Lung Injury Develops Rapidly Irrespective of Resuscitation Strategy in the Rat

Wu, X., Schwacha, M. G., Dubick, M. A., Cap, A. P. & Darlington, D. N., May 11 2016, (Accepted/In press) In : Shock.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Activated skin γδ T-cells regulate T-cell infiltration of the wound site after burn

Rani, M., Zhang, Q., Scherer, M. R., Cap, A. P. & Schwacha, M. G., Feb 8 2015, In : Innate Immunity. 21, 2, p. 140-150 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

A rat model of concurrent combined injuries (polytrauma)

Akscyn, R. M., Franklin, J. L., Gavrikova, T. A., Schwacha, M. G. & Messina, J. L., Nov 30 2015, In : International Journal of Clinical and Experimental Medicine. 8, 11, p. 20097-20110 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Gamma Delta T Cells Regulate Inflammatory Cell Infiltration of the Lung after Trauma-Hemorrhage

Rani, M., Zhang, Q., Oppeltz, R. F. & Schwacha, M. G., Jun 4 2015, In : Shock. 43, 6, p. 589-597 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

The association between the Th-17 immune response and pulmonary complications in a trauma ICU population

Holloway, T. L., Rani, M., Cap, A. P., Stewart, R. M. & Schwacha, M. G., Dec 1 2015, In : Cytokine. 76, 2, p. 328-333 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Trauma-induced coagulopathy is associated with a complex inflammatory response in the rat

Darlington, D. N., Gonzales, M. D., Craig, T., Dubick, M. A., Cap, A. P. & Schwacha, M. G., Aug 1 2015, In : Shock. 44, p. 129-137 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

An experimental model of hemothorax autotransfusion: Impact on coagulation

Harrison, H. B., Smith, W. Z., Salhanick, M. A., Higgins, R. A., Ortiz, A., Olson, J. D., Schwacha, M. G., Harrison, C. R., Aydelotte, J. D., Stewart, R. M. & Dent, D. L., Dec 1 2014, In : American journal of surgery. 208, 6, p. 1078-1082 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Burn wound γδ T-cells support a Th2 and Th17 immune response

Rani, M., Zhang, Q. & Schwacha, M. G., 2014, In : Journal of Burn Care and Research. 35, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Gamma delta t cells regulate wound myeloid CELL activity after burn

Rani, M., Zhang, Q. & Schwacha, M. G., Aug 2014, In : Shock. 42, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mitochondrial damage-associated molecular patterns activate γδ T-cells

Schwacha, M. G., Rani, M., Zhang, Q., Nunez-Cantu, O. & Cap, A. P., Jan 1 2014, In : Innate Immunity. 20, 3, p. 261-268 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Acute coagulopathy of trauma in the rat

Darlington, D. N., Craig, T., Gonzales, M. D., Schwacha, M. G., Cap, A. P. & Dubick, M. A., May 1 2013, In : Shock. 39, 5, p. 440-446 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

A small amount can make a difference: A prospective human study of the paradoxical coagulation characteristics of hemothorax

Smith, W. Z., Harrison, H. B., Salhanick, M. A., Higgins, R. A., Ortiz, A., Olson, J. D., Schwacha, M. G., Harrison, C. R., Aydelotte, J. D., Stewart, R. M. & Dent, D. L., Dec 1 2013, In : American Journal of Surgery. 206, 6, p. 904-910 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Aging and the pathogenic response to burn

Rani, M. & Schwacha, M. G., Jan 1 2012, In : Aging and Disease. 3, 2, p. 171-180 10 p.

Research output: Contribution to journalReview article

27 Scopus citations

Burn enhances toll-like receptor induced responses by circulating leukocytes

Schwacha, M. G., Zhang, Q., Rani, M., Craig, T. & Oppeltz, R. F., Apr 26 2012, In : International Journal of Clinical and Experimental Medicine. 5, 2, p. 136-144 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Differential expression of the immunoinflammatory response in trauma patients: Burn vs. non-burn

Mace, J. E., Park, M. S., Mora, A. G., Chung, K. K., Martini, W., White, C. E., Holcomb, J. B., Merrill, G. A., Dubick, M. A., Wolf, S. E., Wade, C. E. & Schwacha, M. G., Jun 1 2012, In : Burns. 38, 4, p. 599-606 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Gamma delta (γδ) T-cells are critical in the up-regulation of inducible nitric oxide synthase at the burn wound site

Oppeltz, R. F., Rani, M., Zhang, Q. & Schwacha, M. G., Nov 1 2012, In : Cytokine. 60, 2, p. 528-534 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Burn-induced alterations in toll-like receptor-mediated responses by bronchoalveolar lavage cells

Oppeltz, R. F., Rani, M., Zhang, Q. & Schwacha, M. G., Sep 1 2011, In : Cytokine. 55, 3, p. 396-401 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Burn induces a Th-17 inflammatory response at the injury site

Sasaki, J. R., Zhang, Q. & Schwacha, M. G., Jun 1 2011, In : Burns. 37, 4, p. 646-651 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

The role of γδ T-cells in the healing of burn wounds

Oppeltz, R. F. & Schwacha, M. G., Dec 1 2011, Wound Healing: Process, Phases and Promoting. Nova Science Publishers, Inc., p. 95-108 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter