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  • Hui-ming Huang
2020

Attenuation of NAD[P]H:quinone oxidoreductase 1 aggravates prostate cancer and tumor cell plasticity through enhanced TGFβ signaling

Thapa, D., Huang, S. B., Muñoz, A. R., Yang, X., Bedolla, R. G., Hung, C. N., Chen, C. L., Huang, T. H. M., Liss, M. A., Reddick, R. L., Miyamoto, H., Kumar, A. P. & Ghosh, R., Dec 1 2020, In : Communications Biology. 3, 1, 12.

Research output: Contribution to journalArticle

Open Access

Comparative evaluation of network features for the prediction of breast cancer metastasis

Adnan, N., Liu, Z., Huang, T. H. M. & Ruan, J., Apr 3 2020, In : BMC Medical Genomics. 13, 40.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Detection of DNA methylation by MeDIP and MBDCap assays: An overview of techniques

Hsu, H. K., Weng, Y. I., Hsu, P. Y., Huang, T. H. M. & Huang, Y. W., 2020, Methods in Molecular Biology. Humana Press, p. 225-234 10 p. (Methods in Molecular Biology; vol. 2102).

Research output: Chapter in Book/Report/Conference proceedingChapter

Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance

Bi, M., Zhang, Z., Jiang, Y. Z., Xue, P., Wang, H., Lai, Z., Fu, X., De Angelis, C., Gong, Y., Gao, Z., Ruan, J., Jin, V. X., Marangoni, E., Montaudon, E., Glass, C. K., Li, W., Huang, T. H. M., Shao, Z. M., Schiff, R., Chen, L. & 1 others, Liu, Z., Jun 1 2020, In : Nature Cell Biology. 22, 6, p. 701-715 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

Lin, C. L., Tan, X., Chen, M., Kusi, M., Hung, C. N., Chou, C. W., Hsu, Y. T., Wang, C. M., Kirma, N., Chen, C. L., Lin, C. H., Lathrop, K. I., Elledge, R., Kaklamani, V. G., Mitsuya, K. & Huang, T. H. M., May 14 2020, In : BMC Medical Genomics. 13, 1, 69.

Research output: Contribution to journalArticle

Open Access

Single-cell proteomic profiling identifies combined AXL and JAK1 inhibition as a novel therapeutic strategy for lung cancer

Taverna, J. A., Hung, C. N., DeArmond, D. T., Chen, M., Lin, C. L., Osmulski, P. A., Gaczynska, M. E., Wang, C. M., Lucio, N. D., Chou, C. W., Chen, C. L., Nazarullah, A., Lampkin, S. R., Qiu, L., Bearss, D. J., Warner, S., Whatcott, C. J., Mouritsen, L., Wade, M., Weitman, S. & 4 others, Mesa, R. A., Kirma, N. B., Chao, W. T. & Huang, T. H. M., Apr 1 2020, In : Cancer Research. 80, 7, p. 1551-1563 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Xiong, L., Wu, F., Wu, Q., Xu, L., Cheung, O. K., Kang, W., Mok, M. T., Szeto, L. L. M., Lun, C. Y., Lung, R. W., Zhang, J., Yu, K. H., Lee, S. D., Huang, G., Wang, C. M., Liu, J., Yu, Z., Yu, D. Y., Chou, J. L., Huang, W. H. & 10 others, Feng, B., Cheung, Y. S., Lai, P. B., Tan, P., Wong, N., Chan, M. W., Huang, H., Yip, K. Y., Cheng, A. S. & To, K. F., Dec 1 2019, In : Nature communications. 10, 1, 335.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Adipokines deregulate cellular communication via epigenetic repression of gap junction loci in obese endometrial cancer

Polusani, S. R., Huang, Y. W., Huang, G., Chen, C. W., Wang, C. M., Lin, L. L., Osmulski, P., Lucio, N. D., Liu, L., Hsu, Y. T., Zhou, Y., Lin, C. L., Aguilera-Barrantes, I., Valente, P. T., Kost, E. R., Chen, C. L., Shim, E. Y., Lee, S. E., Ruan, J., Gaczynska, M. E. & 7 others, Yan, P., Goodfellow, P. J., Mutch, D. G., Jin, V. X., Nicholson, B. J., Huang, T. H. M. & Kirma, N. B., Jan 1 2019, In : Cancer Research. 79, 1, p. 196-208 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer

Zhu, C., Li, L., Zhang, Z., Bi, M., Wang, H., Su, W., Hernandez, K., Liu, P., Chen, J., Chen, M., Huang, T. H. M., Chen, L. & Liu, Z., Aug 22 2019, In : Molecular Cell. 75, 4, p. 791-806.e8

Research output: Contribution to journalArticle

7 Scopus citations

A novel algorithm for network-based prediction of cancer recurrence

Ruan, J., Jahid, M. J., Gu, F., Lei, C., Huang, Y. W., Hsu, Y. T., Mutch, D. G., Chen, C. L., Kirma, N. B. & Huang, T. H. M., Jan 2019, In : Genomics. 111, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

SOX11 hypermethylation as a tumor biomarker in endometrial cancer

Shan, T., Uyar, D. S., Wang, L. S., Mutch, D. G., Huang, T. H. M., Rader, J. S., Sheng, X. & Huang, Y. W., Jul 2019, In : Biochimie. 162, p. 8-14 7 p.

Research output: Contribution to journalArticle

Spatial EGFR dynamics and metastatic phenotypes modulated by upregulated Ephb2 and Src pathways in advanced prostate cancer

Liu, Y. L., Horning, A. M., Lieberman, B., Kim, M., Lin, C. K., Hung, C. N., Chou, C. W., Wang, C. M., Lin, C. L., Kirma, N. B., Liss, M. A., Vasisht, R., Perillo, E. P., Blocher, K., Horng, H., Taverna, J. A., Ruan, J., Yankeelov, T. E., Dunn, A. K., Huang, T. H. M. & 2 others, Yeh, H. C. & Chen, C. L., Dec 2019, In : Cancers. 11, 12, 1910.

Research output: Contribution to journalArticle

Open Access
2018

BRCA1 interacting protein COBRA1 facilitates adaptation to castrate-resistant growth conditions

Yun, H., Bedolla, R., Horning, A., Li, R., Chiang, H. C., Huang, T. H., Reddick, R., Olumi, A. F., Ghosh, R. & Kumar, A. P., Jul 2018, In : International journal of molecular sciences. 19, 7, 2104.

Research output: Contribution to journalArticle

3 Scopus citations

Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

Panneerdoss, S., Eedunuri, V. K., Yadav, P., Timilsina, S., Rajamanickam, S., Viswanadhapalli, S., Abdelfattah, N., Onyeagucha, B. C., Cui, X., Lai, Z., Mohammad, T. A., Gupta, Y. K., Huang, T. H. M., Huang, Y., Chen, Y. & Rao, M. K., Oct 3 2018, In : Science advances. 4, 10, eaar8263.

Research output: Contribution to journalArticle

39 Scopus citations

Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors

Liew, P. L., Huang, R. L., Weng, Y. C., Fang, C. L., Huang, H. & Lai, H. C., Jul 15 2018, In : International Journal of Cancer. 143, 2, p. 355-367 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., Geraghty, C., Yan, P. S., Hankey, W., Sunkel, B., Cheng, X., Antonarakis, E. S., Wang, Q. E., Liu, Z., Huang, T. H. M., Jin, V. X., Clinton, S. K., Luo, J., Huang, J. & Wang, Q., Jun 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. 6810-6815 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation

Zhang, W., Chen, J. H., Shan, T., Aguilera-Barrantes, I., Wang, L. S., Huang, T. H. M., Rader, J. S., Sheng, X. & Huang, Y. W., Nov 1 2018, In : Laboratory Investigation. 98, 11, p. 1397-1407 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Single-Cell RNA-seq reveals a subpopulation of prostate cancer cells with enhanced cell-Cycle–Related transcription and attenuated androgen response

Horning, A. M., Wang, Y., Lin, C. K., Louie, A. D., Jadhav, R. R., Hung, C. N., Wang, C. M., Lin, C. L., Kirma, N. B., Liss, M. A., Kumar, A. P., Sun, L., Liu, Z., Chao, W. T., Wang, Q., Jin, V. X., Chen, C. & Huang, H., Feb 15 2018, In : Cancer Research. 78, 4, p. 853-864 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation

Hussain, S. S., Huang, S. B., Bedolla, R. G., Rivas, P., Basler, J. W., Swanson, G. P., Hui-Ming Huang, T., Narayanasamy, G., Papanikolaou, N., Miyamoto, H., Yeh, I. T., Reddick, R. L., Pollock, B. H., Ghosh, R. & Kumar, A. P., Oct 1 2018, In : Cancer Letters. 433, p. 232-241 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tamoxifen resistance in breast cancer is regulated by the EZH2–ERa–GREB1 transcriptional axis

Wu, Y., Zhang, Z., Cenciarini, M. E., Proietti, C. J., Amasino, M., Hong, T., Yang, M., Liao, Y., Chiang, H. C., Kaklamani, V. G., Jeselsohn, R., Vadlamudi, R. K., Huang, T. H. M., Li, R., De Angelis, C., Fu, X., Elizalde, P. V., Schiff, R., Brown, M. & Xu, K., Feb 1 2018, In : Cancer Research. 78, 3, p. 671-684 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2017

Cellular cholesterol regulates monocyte deformation

Saha, A. K., Dallo, S. F., Detmar, A. L., Osmulski, P., Gaczynska, M. E., Huang, H. & Ramasubramanian, A. K., 2017, In : Journal of Biomechanics. 52, p. 83-88 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cholesterol Regulates Monocyte Rolling through CD44 Distribution

Saha, A. K., Osmulski, P., Dallo, S. F., Gaczynska, M. E., Huang, H. & Ramasubramanian, A. K., Apr 11 2017, In : Biophysical Journal. 112, 7, p. 1481-1488 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Complete Transcriptome RNA-Seq

Miller, D. F. B., Yan, P., Fang, F., Buechlein, A., Kroll, K., Frankhouser, D., Stump, C., Stump, P., Ford, J. B., Tang, H., Michaels, S., Matei, D., Huang, T. H., Chien, J., Liu, Y., Rusch, D. B. & Nephew, K. P., 2017, Methods in Molecular Biology. Humana Press, p. 141-162 22 p. (Methods in Molecular Biology; vol. 1513).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Computational methods and correlation of Exon-skipping events with splicing, transcription, and epigenetic factors

Wang, J., Ye, Z., Huang, H., Shi, H. & Jin, V. X., 2017, Methods in Molecular Biology. Humana Press, Vol. 1513. p. 163-170 8 p. (Methods in Molecular Biology; vol. 1513).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix

Shen-Gunther, J., Wang, Y., Lai, Z., Poage, G. M., Perez, L. & Huang, T. H. M., Mar 14 2017, In : BMC genomics. 18, 1, 231.

Research output: Contribution to journalArticle

12 Scopus citations

DNA methylation targets influenced by bisphenol A and/or genistein are associated with survival outcomes in breast cancer patients

Jadhav, R. R., Santucci-Pereira, J., Wang, Y. V., Liu, J., Nguyen, T. D., Wang, J., Jenkins, S., Russo, J., Huang, H., Jin, V. X. & Lamartiniere, C. A., May 15 2017, In : Genes. 8, 5, 144.

Research output: Contribution to journalArticle

12 Scopus citations

EGFR-dependent regulated intramembrane proteolysis of EpCAM - Response

Hsu, Y. T., Osmulski, P., Wang, Y., Huang, Y. W., Liu, L., Ruan, J., Jin, V. X., Kirma, N. B., Gaczynska, M. E. & Huang, T. H. M., 2017, In : Cancer Research. 77, 7, p. 1777 1 p.

Research output: Contribution to journalLetter

Integrated epigenomics analysis reveals a DNA methylation panel for endometrial cancer detection using cervical scrapings

Huang, R. L., Su, P. H., Liao, Y. P., Wu, T. I., Hsu, Y. T., Lin, W. Y., Wang, H. C., Weng, Y. C., Ou, Y. C., Huang, T. H. M. & Lai, H. C., Jan 1 2017, In : Clinical Cancer Research. 23, 1, p. 263-272 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
10 Scopus citations

Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence

Sunkel, B., Wu, D., Chen, Z., Wang, C. M., Liu, X., Ye, Z., Horning, A. M., Liu, J., Mahalingam, D., Lopez-Nicora, H., Lin, C. L., Goodfellow, P. J., Clinton, S. K., Jin, V. X., Chen, C. L., Huang, T. H. M. & Wang, Q., Jun 20 2017, In : Nucleic acids research. 45, 11, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

JAK2V617F influences epigenomic changes in myeloproliferative neoplasms

Chen, C. C., Chiu, C. C., Lee, K. D., Hsu, C. C., Chen, H. C., Huang, H., Hsiao, S. H. & Leu, Y. W., Dec 16 2017, In : Biochemical and Biophysical Research Communications. 494, 3-4, p. 470-476 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, H., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 1 2017, In : Cancer immunology research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Reprimo, a potential p53-dependent tumor suppressor gene, is frequently hypermethylated in estrogen receptor α-positive breast cancer

Buchegger, K., Riquelme, I., Viscarra, T., Ili, C., Brebi, P., Huang, T. H. M. & Roa, J. C., Aug 15 2017, In : International journal of molecular sciences. 18, 8, 1525.

Research output: Contribution to journalArticle

1 Scopus citations

START: A system for flexible analysis of hundreds of genomic signal tracks in few lines of SQL-like queries

Zhu, X., Zhang, Q., Ho, E. D., Yu, K. H. O., Liu, C., Huang, T. H., Cheng, A. S. L., Kao, B., Lo, E. & Yip, K. Y., Sep 22 2017, In : BMC genomics. 18, 1, 749.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Crosstalk between RON and androgen receptor signaling in the development of castration resistant prostate cancer

Batth, I., Yun, H., Hussain, S., Meng, P., Osumulski, P., Huang, T. H. M., Bedolla, R., Profit, A., Reddick, R. & Kumar, A., Mar 22 2016, In : Oncotarget. 7, 12, p. 14048-14063 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers

Hsiao, T. H., Chiu, Y. C., Hsu, P. Y., Lu, T. P., Lai, L. C., Tsai, M. H., Huang, H., Chuang, E. Y. & Chen, Y., Mar 14 2016, In : Scientific Reports. 6, 23035.

Research output: Contribution to journalArticle

16 Scopus citations
18 Scopus citations

Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1

Ye, Z., Chen, Z., Sunkel, B., Frietze, S., Huang, T. H. M., Wang, Q. & Jin, V. X., Sep 19 2016, In : Nucleic acids research. 44, 16, p. 7540-7554 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence

Sunkel, B., Wu, D., Chen, Z., Wang, C. M., Liu, X., Ye, Z., Horning, A. M., Liu, J., Mahalingam, D., Lopez-Nicora, H., Lin, C. L., Goodfellow, P. J., Clinton, S. K., Jin, V. X., Chen, C. L., Huang, T. H. M. & Wang, Q., May 19 2016, In : Nucleic acids research. 44, 9, p. 4105-4122 18 p.

Research output: Contribution to journalArticle

14 Scopus citations

Methyl-binding DNA capture sequencing for patient tissues

Jadhav, R. R., Wang, Y. V., Hsu, Y. T., Liu, J., Garcia, D., Lai, Z., Huang, T. H. M. & Jin, V. X., Oct 31 2016, In : Journal of Visualized Experiments. 2016, 116, e54131.

Research output: Contribution to journalArticle

1 Scopus citations

MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1

Venturutti, L., Cordo Russo, R. I., Rivas, M. A., Mercogliano, M. F., Izzo, F., Oakley, R. H., Pereyra, M. G., De Martino, M., Proietti, C. J., Yankilevich, P., Roa, J. C., Guzmán, P., Cortese, E., Allemand, D. H., Huang, T. H., Charreau, E. H., Cidlowski, J. A., Schillaci, R. & Elizalde, P. V., Dec 1 2016, In : Oncogene. 35, 48, p. 6189-6202 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology

Shen-Gunther, J., Wang, C. M., Poage, G. M., Lin, C. L., Perez, L., Banks, N. A. & Huang, T. H. M., Sep 13 2016, In : Clinical Epigenetics. 8, 1, 96.

Research output: Contribution to journalArticle

13 Scopus citations

NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

Özeş, A. R., Miller, D. F., Özeş, O. N., Fang, F., Liu, Y., Matei, D., Huang, T. & Nephew, K. P., Oct 13 2016, In : Oncogene. 35, 41, p. 5350-5361 12 p.

Research output: Contribution to journalArticle

120 Scopus citations

Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line

Buchegger, K., Ili, C., Riquelme, I., Letelier, P., Corvalán, A. H., Brebi, P., Huang, H. & Roa, J. C., Jan 22 2016, (Accepted/In press) In : Biological Research.

Research output: Contribution to journalArticle

11 Scopus citations

Roles of distal and genic methylation in the development of prostate tumorigenesis revealed by genome-wide DNA methylation analysis

Wang, Y., Jadhav, R. R., Liu, J., Wilson, D., Chen, Y., Thompson, I. M., Troyer, D. A., Hernandez, J., Shi, H., Leach, R. J., Huang, T. H. M. & Jin, V. X., Jan 1 2016, In : Scientific reports. 6, 22051.

Research output: Contribution to journalArticle

12 Scopus citations

Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells

Hsu, P. Y., Hsu, H. K., Hsiao, T. H., Ye, Z., Wang, E., Profit, A. L., Jatoi, I., Chen, Y., Kirma, N. B., Jin, V. X., Sharp, Z. D. & Huang, T. H. M., May 5 2016, In : Oncogene. 35, 18, p. 2379-2389 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts

Huang, G., Osmulski, P. A., Bouamar, H., Mahalingam, D., Lin, C. L., Liss, M. A., Kumar, A. P., Chen, C. L., Thompson, I. M., Sun, L. Z., Gaczynska, M. E. & Huang, T. H. M., 2016, In : Oncotarget. 7, 47, p. 77124-77137 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Aberrant epigenetic modifications in radiation-resistant head and neck cancers

Lin, H. Y., Huang, T. H. M. & Chan, M. W. Y., Jan 1 2015, In : Methods in Molecular Biology. 1238, p. 321-332 12 p.

Research output: Contribution to journalArticle

Active surveillance is an appropriate management strategy for a proportion of men diagnosed with prostate cancer by prostate specific antigen testing

Thompson, I. M., Overholser, S., Nielsen, M., Torkko, K., Cwilka, D., Weaver, B., Shi, X., Leach, R. J., Hernandez, J., Huang, H. & Thompson, I. M., Sep 1 2015, In : Journal of Urology. 194, 3, p. 680-684 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer

Chen, Z., Lan, X., Thomas-Ahner, J. M., Wu, D., Liu, X., Ye, Z., Wang, L., Sunkel, B., Grenade, C., Chen, J., Zynger, D. L., Yan, P. S., Huang, J., Nephew, K. P., Huang, T. H. M., Lin, S., Clinton, S. K., Li, W., Jin, V. X. & Wang, Q., Feb 12 2015, In : EMBO Journal. 34, 4, p. 502-516 15 p.

Research output: Contribution to journalArticle

34 Scopus citations