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  • Paolo Casali
2020

B cell endosomal RAB7 promotes TRAF6 K63 polyubiquitination and NF-κB activation for antibody class-switching

Yan, H., Fernandez, M., Wang, J., Wu, S., Wang, R., Lou, Z., Moroney, J. B., Rivera, C. E., Taylor, J. R., Gan, H., Zan, H., Kolvaskyy, D., Liu, D., Casali, P. & Xu, Z., Mar 1 2020, In : Journal of Immunology. 204, 5, p. 1146-1157 12 p.

Research output: Contribution to journalArticle

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

Sanchez, H. N., Moroney, J. B., Gan, H., Shen, T., Im, J. L., Li, T., Taylor, J. R., Zan, H. & Casali, P., Dec 1 2020, In : Nature communications. 11, 1, 60.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

Gan, H., Shen, T., Chupp, D. P., Taylor, J. R., Sanchez, H. N., Li, X., Xu, Z., Zan, H. & Casali, P., Apr 1 2020, In : Science Advances. 6, 14, eaay2793.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Erratum: Correction: B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching (Journal of immunology (Baltimore, Md. : 1950) (2020) 204 5 (1146-1157))

Yan, H., Fernandez, M., Wang, J., Wu, S., Wang, R., Lou, Z., Moroney, J. B., Rivera, C. E., Taylor, J. R., Gan, H., Zan, H., Kovalskyy, D., Liu, D., Casali, P. & Xu, Z., Jun 1 2020, In : Journal of immunology (Baltimore, Md. : 1950). 204, 11, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

Casali, P., Shen, T., Xu, Y., Qiu, Z., Chupp, D. P., Im, J., Xu, Z. & Zan, H., Mar 24 2020, In : Frontiers in immunology. 11, 491.

Research output: Contribution to journalArticle

Open Access
2017
1 Scopus citations

Identification of IL-40, a novel B cell-associated cytokine

Catalan-Dibene, J., Vazquez, M. I., Luu, V. P., Nuccio, S. P., Karimzadeh, A., Kastenschmidt, J. M., Villalta, S. A., Ushach, I., Pone, E. J., Casali, P., Raffatellu, M., Burkhardt, A. M., Hernandez-Ruiz, M., Heller, G., Hevezi, P. A. & Zlotnik, A., Nov 1 2017, In : Journal of Immunology. 199, 9, p. 3326-3335 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

Zan, H., Tat, C., Qiu, Z., Taylor, J. R., Guerrero, J. A., Shen, T. & Casali, P., Feb 8 2017, In : Nature Communications. 8, 14244.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Editorial: Epigenetics of B cells and antibody responses

Zan, H. & Casali, P., Jan 1 2016, In : Frontiers in Immunology. 6, JAN, 656.

Research output: Contribution to journalEditorial

Small molecule inhibition of Rab7 impairs B cell class switching and plasma cell survival to dampen the autoantibody response in murine lupus

Lam, T., Kulp, D. V., Wang, R., Lou, Z., Taylor, J., Rivera, C. E., Yan, H., Zhang, Q., Wang, Z., Zan, H., Ivanov, D. N., Zhong, G., Casali, P. & Xu, Z., Nov 15 2016, In : Journal of Immunology. 197, 10, p. 3792-3805 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses

Pone, E. J., Lam, T., Lou, Z., Wang, R., Chen, Y., Liu, D., Edinger, A. L., Xu, Z. & Casali, P., Apr 1 2015, In : Journal of Immunology. 194, 7, p. 3065-3078 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses

Pone, E. J., Lou, Z., Lam, T., Greenberg, M. L., Wang, R., Xu, Z. & Casali, P., Feb 1 2015, In : Autoimmunity. 48, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Epigenetics of peripheral B-cell differentiation and the antibody response

Zan, H. & Casali, P., Jan 1 2015, In : Frontiers in Immunology. 6, DEC, 631.

Research output: Contribution to journalReview article

42 Scopus citations
16 Scopus citations
10 Scopus citations
2014

Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and blimp-1 expression for epigenetic modulation of antibody and autoantibody responses

White, C. A., Pone, E. J., Lam, T., Tat, C., Hayama, K. L., Li, G., Zan, H. & Casali, P., Dec 15 2014, In : Journal of Immunology. 193, 12, p. 5933-5950 18 p.

Research output: Contribution to journalArticle

50 Scopus citations

MicroRNAs in lupus

Zan, H., Tat, C. & Casali, P., Jun 2014, In : Autoimmunity. 47, 4, p. 272-285 14 p.

Research output: Contribution to journalReview article

35 Scopus citations

Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses

Morgado, P., Sudarshana, D. M., Gov, L., Harker, K. S., Lam, T., Casali, P., Boyle, J. P. & Lodoen, M. B., Jan 1 2014, In : Infection and Immunity. 82, 10, p. 4047-4055 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells

Park, S. R., Kim, P. H., Lee, K. S., Lee, S. H., Seo, G. Y., Yoo, Y. C., Lee, J. & Casali, P., Feb 2013, In : Cytokine. 61, 2, p. 608-613 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Combinatorial H3K9acS10ph histone modification in igh locus s regions targets 14-3-3 adaptors and aid to specify antibody class-switch DNA recombination

Li, G., White, C. A., Lam, T., Pone, E. J., Tran, D. C., Hayama, K. L., Zan, H., Xu, Z. & Casali, P., Oct 28 2013, In : Cell Reports. 5, 3, p. 702-714 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Epigenetics of the antibody response

Li, G., Zan, H., Xu, Z. & Casali, P., Sep 1 2013, In : Trends in Immunology. 34, 9, p. 460-470 11 p.

Research output: Contribution to journalReview article

51 Scopus citations

Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5′-CpG-3′-rich 14-3-3γ promoter and is sustained by E2A

Mai, T., Pone, E. J., Li, G., Lam, T. S., Moehlman, J., Xu, Z. & Casali, P., Aug 15 2013, In : Journal of Immunology. 191, 4, p. 1895-1906 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of Aicda expression and AID activity

Zan, H. & Casali, P., Feb 18 2013, In : Autoimmunity. 46, 2, p. 83-101 19 p.

Research output: Contribution to journalReview article

64 Scopus citations

Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination

Lam, T., Thomas, L. M., White, C. A., Li, G., Pone, E. J., Xu, Z. & Casali, P., Nov 25 2013, In : PloS one. 8, 11, e80414.

Research output: Contribution to journalArticle

16 Scopus citations

TSPAN33 is a novel marker of activated and malignant B cells

Luu, V. P., Hevezi, P., Vences-Catalan, F., Maravillas-Montero, J. L., White, C. A., Casali, P., Llorente, L., Jakez-Ocampo, J., Lima, G., Vilches-Cisneros, N., Flores-Gutiérrez, J. P., Santos-Argumedo, L. & Zlotnik, A., Dec 2013, In : Clinical Immunology. 149, 3 PB, p. 388-399 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

Pone, E. J., Zhang, J., Mai, T., White, C. A., Li, G., Sakakura, J. K., Patel, P. J., Al-Qahtani, A., Zan, H., Xu, Z. & Casali, P., 2012, In : Nature communications. 3, 767.

Research output: Contribution to journalArticle

119 Scopus citations

Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond

Xu, Z., Zan, H., Pone, E. J., Mai, T. & Casali, P., Jul 1 2012, In : Nature Reviews Immunology. 12, 7, p. 517-531 15 p.

Research output: Contribution to journalReview article

204 Scopus citations

Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination

Li, G., Pone, E. J., Tran, D. C., Patel, P. J., Dao, L., Xu, Z. & Casali, P., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 21520-21529 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

Zan, H., White, C. A., Thomas, L. M., Mai, T., Li, G., Xu, Z., Zhang, J. & Casali, P., Nov 29 2012, In : Cell Reports. 2, 5, p. 1220-1232 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

AID dysregulation in lupus-prone MRL/Fas lpr/lpr mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: Modulation by HoxC4

White, C. A., Seth Hawkins, J., Pone, E. J., Yu, E. S., Al-Qahtani, A., Mai, T., Zan, H. & Casali, P., Dec 1 2011, In : Autoimmunity. 44, 8, p. 585-598 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

B cell TLRs and induction of immunoglobulin class-switch DNA recombination

Pone, E. J., Xu, Z., White, C. A., Zan, H. & Casali, P., Jun 1 2011, In : Frontiers in Bioscience. 17, 7, p. 2594-2615 22 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions

Zan, H., Zhang, J., Al-Qahtani, A., Pone, E. J., White, C. A., Lee, D., Yel, L., Mai, T. & Casali, P., Jan 1 2011, In : Molecular Immunology. 48, 4, p. 610-622 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erratum: AID dysregulation in lupus-prone MRL/Faslpr/lpr mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: Modulation by HoxC4 (Autoimmunity (2011) 44: 8 (664))

White, C. A., Hawkins, J. S., Pone, E. J., Yu, E. S., Al-Qahtani, A., Mai, T., Zan, H. & Casali, P., Dec 1 2011, In : Autoimmunity. 44, 8, 1 p.

Research output: Contribution to journalComment/debate