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  • Ralph A Defronzo
2020

Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study

China Cardiometabolic Disease and Cancer Cohort Study Group, Feb 2020, In : The Lancet Diabetes and Endocrinology. 8, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Combination therapy with canagliflozin plus liraglutide exerts additive effect on weight loss, but not on HbA1c, in patients with type 2 diabetes

Ali, A. M., Martinez, R., Al-Jobori, H., Adams, J., Triplitt, C., DeFronzo, R., Cersosimo, E. & Abdul-Ghani, M., Jun 1 2020, In : Diabetes care. 43, 6, p. 1234-1241 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Consensus statement by the American Association of clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2020 executive summary

Garber, A. J., Handelsman, Y., Grunberger, G., Einhorn, D., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bush, M. A., DeFronzo, R. A., Garber, J. R., Timothy Garvey, W., Hirsch, I. B., Jellinger, P. S., McGill, J. B., Mechanick, J. I., Perreault, L., Rosenblit, P. D., Samson, S. & Umpierrez, G. E., Jan 1 2020, In : Endocrine Practice. 26, 1, p. 107-139 33 p.

Research output: Contribution to journalReview article

10 Scopus citations

Culture on a native bone marrow-derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity

Wang, H., Li, S., Dai, Q., Gonzalez, A., Tran, O. N., Sun, H., DeFronzo, R. A., Dean, D. D., Yeh, C. K. & Chen, X. D., Jun 1 2020, In : FASEB Journal. 34, 6, p. 8044-8056 13 p.

Research output: Contribution to journalArticle

Open Access

Effect of treatment with exenatide and pioglitazone or basal-bolus insulin on diabetic neuropathy: A substudy of the Qatar Study

Ponirakis, G., Ponirakis, G., Abdul-Ghani, M. A., Jayyousi, A., Almuhannadi, H., Petropoulos, I. N., Khan, A., Gad, H., Migahid, O., Megahed, A., Defronzo, R., Mahfoud, Z., Hassan, M., Al Hamad, H., Ramadan, M. & Alam, U., Jun 23 2020, In : BMJ Open Diabetes Research and Care. 8, 1, e001420.

Research output: Contribution to journalArticle

Open Access

Evidence against an important role of plasma insulin and glucagon concentrations in the increase in EGP caused by SGLT2 inhibitors

Alatrach, M., Laichuthai, N., Martinez, R., Agyin, C., Ali, A. M., Al-Jobori, H., Lavynenko, O., Adams, J., Triplitt, C., DeFronzo, R., Cersosimo, E. & Abdul-Ghani, M., Apr 1 2020, In : Diabetes. 69, 4, p. 681-688 8 p.

Research output: Contribution to journalArticle

Open Access

Evidence for gene-smoking interactions for hearing loss and deafness in Japanese American families

American Diabetes Association GENNID Study Group, Mar 1 2020, In : Hearing Research. 387, 107875.

Research output: Contribution to journalArticle

4 Scopus citations

Increase in endogenous glucose production with SGLT2 inhibition is unchanged by renal denervation and correlates strongly with the increase in urinary glucose excretion

Solis-Herrera, C., Daniele, G., Alatrach, M., Agyin, C., Triplitt, C., Adams, J., Patel, R., Gastaldelli, A., Honka, H., Chen, X., Abdul-Ghani, M., Cersosimo, E., Prato, S. D. & DeFronzo, R., May 1 2020, In : Diabetes care. 43, 5, p. 1065-1069 5 p.

Research output: Contribution to journalArticle

2019

A neural signature of metabolic syndrome

Kotkowski, E., Price, L. R., Franklin, C., Salazar, M., Woolsey, M., DeFronzo, R. A., Blangero, J. C., Glahn, D. C. & Fox, P. T., Aug 15 2019, In : Human Brain Mapping. 40, 12, p. 3575-3588 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary

Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Fonseca, V. A., Garber, J. R., Garvey, W. T., Grunberger, G., Handelsman, Y., Hirsch, I. B., Jellinger, P. S., McGill, J. B., Mechanick, J. I., Rosenblit, P. D. & Umpierrez, G. E., Jan 2019, In : Endocrine Practice. 25, 1, p. 69-100 32 p.

Research output: Contribution to journalReview article

96 Scopus citations

Exenatide modulates visual cortex responses

Binda, P., Eldor, R., Huerta, C., Adams, J., Lancaster, J., Fox, P., Del Prato, S., DeFronzo, R., Abdul-Ghani, M. & Daniele, G., Sep 1 2019, In : Diabetes/Metabolism Research and Reviews. 35, 6, e3167.

Research output: Contribution to journalArticle

Open Access

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES & AMP-T2D-GENES, Jun 6 2019, In : Nature. 570, 7759, p. 71-76 6 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG

Alatrach, M., Agyin, C., Mehta, R., Adams, J., Defronzo, R. A. & Abdul-ghani, M. A., Jan 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 1, p. 163-171 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population

Iskandar, S., Migahid, A., Kamal, D., Megahed, O., Defronzo, R. A., Zirie, M., Jayyousi, A., Al Jaidah, M. & Abdul-ghani, M. A., Aug 22 2019, In : BMC Endocrine Disorders. 19, 1, 87.

Research output: Contribution to journalArticle

Open Access

Hormone-substrate changes with exenatide plus dapagliflozin versus each drug alone: The randomized, active-controlled DURATION-8 study

Ferrannini, E., Baldi, S., Frías, J. P., Guja, C., Hardy, E., Repetto, E., Jabbour, S. A. & DeFronzo, R. A., Jan 1 2019, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Open Access

Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

Di Pino, A. & Defronzo, R. A., Jan 1 2019, In : Endocrine Reviews. 40, 6, p. 1447-1467 21 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

Fiorentino, T. V., Casiraghi, F., Davalli, A. M., Finzi, G., Rosa, S. L., Higgins, P. B., Abrahamian, G. A., Marando, A., Sessa, F., Perego, C., Guardado-Mendoza, R., Kamath, S., Ricotti, A., Fiorina, P., Daniele, G., Paez, A. M., Andreozzi, F., Bastarrachea, R. A., Comuzzie, A. G., Gastaldelli, A. & 8 others, Chavez, A. O., Di Cairano, E. S., Frost, P., Luzi, L., Dick, E. J., Halff, G. A., DeFronzo, R. A. & Folli, F., Sep 19 2019, In : JCI Insight. 4, 20, e93091.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mechanism of Action of Inhaled Insulin on Whole Body Glucose Metabolism in Subjects with Type 2 Diabetes Mellitus

Mehta, R. J., Gastaldelli, A., Balas, B., Ricotti, A., DeFronzo, R. A. & Tripathy, D., Aug 29 2019, In : International journal of molecular sciences. 20, 17

Research output: Contribution to journalArticle

Open Access

Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose-Tolerant Participants

Tripathy, D., Merovci, A., Basu, R., Abdul-Ghani, M. & Defronzo, R. A., Mar 21 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 7, p. 2842-2850 9 p., jcem_201802304.

Research output: Contribution to journalArticle

3 Scopus citations

Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes

Defronzo, R. A., Inzucchi, S., Abdul-ghani, M. A. & Nissen, S. E., Jan 1 2019, In : Diabetes and Vascular Disease Research.

Research output: Contribution to journalArticle

7 Scopus citations

Pioglitazone prevents the increase in plasma ketone concentration associated with dapagliflozin in insulin-treated T2DM patients: Results from the Qatar Study

Abdul-Ghani, M., Migahid, O., Megahed, A., Singh, R., Fawaz, M., DeFronzo, R. A. & Jayyousi, A., Mar 2019, In : Diabetes, Obesity and Metabolism. 21, 3, p. 705-709 5 p.

Research output: Contribution to journalArticle

2018

A novel experimental model for human mixed acinar-ductal pancreatic cancer

Doiron, B. & Defronzo, R. A., Feb 1 2018, In : Carcinogenesis. 39, 2, p. 180-190 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Associations of Hemoglobin A1c With Cardiovascular Disease and Mortality in Chinese Adults With Diabetes

Lu, J., Wang, W., Li, M., Bi, Y., Xu, Y., Chen, L., Zhao, J., Mu, Y., DeFronzo, R. A. & Ning, G., Dec 18 2018, In : Journal of the American College of Cardiology. 72, 24, p. 3224-3225 2 p.

Research output: Contribution to journalLetter

1 Scopus citations

Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2018 executive summary

Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Fonseca, V. A., Garber, J. R., Garvey, W. T., Grunberger, G., Handelsman, Y., Hirsch, I. B., Jellinger, P. S., McGill, J. B., Mechanick, J. I., Rosenblit, P. D. & Umpierrez, G. E., Jan 2018, In : Endocrine Practice. 24, 1, p. 91-120 30 p.

Research output: Contribution to journalReview article

250 Scopus citations

Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy

Chen, S., Bastarrachea, R. A., Shen, J. S., Laviada-Nagel, A., Rodriguez-Ayala, E., Nava-Gonzalez, E. J., Huang, P., DeFronzo, R. A., Kent, J. W. & Grayburn, P. A., Oct 1 2018, In : Gene Therapy. 25, 7, p. 497-509 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effect of chronic hyperglycemia on glucose metabolism in subjects with normal glucose tolerance

Shannon, C., Merovci, A., Xiong, J., Tripathy, D., Lorenzo, F., McClain, D., Abdul-ghani, M. A., Norton, L. & Defronzo, R. A., Dec 1 2018, In : Diabetes. 67, 12, p. 2507-2517 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of intravenous AICAR (5- aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp

Blanco, C. L., Gastaldelli, A., Anzueto, D. G., Winter, L. A., Seidner, S. R., McCurnin, D. C., Liang, H., Javors, M. A., DeFronzo, R. A. & Musi, N., Dec 2018, In : PloS one. 13, 12, e0208757.

Research output: Contribution to journalArticle

1 Scopus citations

Empagliflozin Treatment Is Associated with Improved β -Cell Function in Type 2 Diabetes Mellitus

Al Jobori, H., Daniele, G., Adams, J., Cersosimo, E., Solis-Herrera, C., Triplitt, C., Defronzo, R. A. & Abdul-Ghani, M., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1402-1407 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endogenous glucose production and hormonal changes in response to canagliflozin and liraglutide combination therapy

Martinez, R., Al-Jobori, H., Ali, A. M., Adams, J., Abdul-Ghani, M., Triplitt, C., DeFronzo, R. A. & Cersosimo, E., Jun 1 2018, In : Diabetes. 67, 6, p. 1182-1189 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 others, Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., van de Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B. J., Kim, Y., Kim, Y. J., Kwon, M. S., Lee, J., Lee, S., Lin, K. H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B. G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S. H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C. Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C. C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S. T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., de Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A. C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C. N., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J. Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E. S., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., Jan 23 2018, In : Scientific Data. 5, 1 p.

Research output: Contribution to journalComment/debate

Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents

Arya, R., Farook, V. S., Fowler, S. P., Puppala, S., Chittoor, G., Resendez, R. G., Mummidi, S., Vanamala, J. M., Almasy, L., Curran, J. E., Comuzzie, A. G., Lehman, D. M., Jenkinson, C. P., Lynch, J. L., DeFronzo, R. A., Blangero, J., Hale, D. E., Duggirala, R. & Diego, V. P., Jun 2018, In : Genetic epidemiology. 42, 4, p. 378-393 16 p.

Research output: Contribution to journalArticle

Insulin resistance the link between t2dm and cvd: Basic mechanisms and clinical implications

Abdul-Ghani, M. A., Jayyousi, A., Defronzo, R. A., Asaad, N. & Al-Suwaidi, J., Jan 1 2018, In : Current Vascular Pharmacology. 17, 2, p. 153-163 11 p.

Research output: Contribution to journalReview article

8 Scopus citations

Insulin secretion predicts the response to therapy with exenatide plus pioglitazone, but not to basal/bolus insulin in poorly controlled T2DM patients: Results from the Qatar study

Abdul-ghani, M. A., Migahid, O., Megahed, A., Singh, R., Kamal, D., Defronzo, R. A. & Jayyousi, A., Apr 1 2018, In : Diabetes, Obesity and Metabolism. 20, 4, p. 1075-1079 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Older subjects with β -cell dysfunction have an accentuated incretin release

De Jesús Garduno-Garcia, J., Gastaldelli, A., Defronzo, R. A., Lertwattanarak, R., Holst, J. J. & Musi, N., Jul 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 7, p. 2613-2619 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Quantitative image-based phosphorus-31 MR spectroscopy for evaluating age-based differences in skeletal muscle metabolites

Deng, S., Ripley, E. M., Vasquez, J. A., Tripathy, D., Defronzo, R. A. & Clarke, G. D., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. SPIE, Vol. 10573. 105732T

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Reduced skeletal muscle phosphocreatine concentration in type 2 diabetic patients: A quantitative image-based phosphorus-31 MR spectroscopy study

Ripley, E. M., Clarke, G. D., Hamidi, V., Martinez, R. A., Settles, F. D., Solis, C., Deng, S., Abdul-ghani, M. A., Tripathy, D. & Defronzo, R. A., Aug 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 2, p. E229-E239

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations

Successful treatment of prediabetes in clinical practice using physiological assessment (STOP DIABETES)

Armato, J. P., Defronzo, R. A., Abdul-ghani, M. A. & Ruby, R. J., Oct 1 2018, In : The Lancet Diabetes and Endocrinology. 6, 10, p. 781-789 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients

Bener, A., Eliaçik, M., Cincik, H., Öztürk, M., Defronzo, R. A. & Abdul-ghani, M. A., Jan 1 2018, In : BioMed Research International. 2018, 2714590.

Research output: Contribution to journalArticle

4 Scopus citations
2017

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes

Broad Genomics Platform, T2D-GENES Consortium, SIGMA T2D Genetics Consortium & Diabetes Prevention Program Research Group, Nov 1 2017, In : Diabetes. 66, 11, p. 2903-2914 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk

Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., Depristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., de Angelis, M. H., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., Defronzo, R. A., Abboud, H. E., Syvänen, A. C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S. T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J. Y., Han, B. G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., E Mel Ander, O. L., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., U, J. L., Khor, C. C., Chia, K. S., Lim, W. Y., Cheng, C. Y., Chan, E., Shyong Tai, E., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Na Kravi C, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Kat, K. H., Farmer, A. J., Frayling, T. M., O’rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stan?cáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Antero Kesaniemi, Y., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Jul 1 2017, In : Diabetes. 66, 7, p. 2019-2032 14 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Cardiovascular disease and type 2 diabetes: Has the dawn of a new era arrived?

Abdul-Ghani, M., DeFronzo, R. A., Del Prato, S., Chilton, R., Singh, R. & Ryder, R. E. J., Jul 1 2017, In : Diabetes care. 40, 7, p. 813-820 8 p.

Research output: Contribution to journalReview article

48 Scopus citations

Combination Therapy with Exenatide Plus Pioglitazone Versus Basal/Bolus Insulin in Patients with Poorly Controlled Type 2 Diabetes on Sulfonylurea Plus Metformin: The Qatar Study

Abdul-Ghani, M., Migahid, O., Megahed, A., Adams, J., Triplitt, C., DeFronzo, R. A., Zirie, M. & Jayyousi, A., Mar 1 2017, In : Diabetes care. 40, 3, p. 325-331 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor

Defronzo, R. A., 2017, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

50 Scopus citations

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2017 EXECUTIVE SUMMARY

Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Fonseca, V. A., Garber, J. R., Garvey, W. T., Grunberger, G., Handelsman, Y., Hirsch, I. B., Jellinger, P. S., McGill, J. B., Mechanick, J. I., Rosenblit, P. D. & Umpierrez, G. E., Feb 1 2017, In : Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 23, 2, p. 207-238 32 p.

Research output: Contribution to journalArticle

275 Scopus citations

Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 others, Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., Van De Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B. J., Kim, Y., Kim, Y. J., Kwon, M. S., Lee, J., Lee, S., Lin, K. H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B. G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S. H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C. Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C. C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S. T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., De Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P. M., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A. C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C. N., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J. Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., Dec 19 2017, In : Scientific Data. 4, 170179.

Research output: Contribution to journalArticle

8 Scopus citations

Decreased basal hepatic glucose uptake in impaired fasting glucose

Alatrach, M., Agyin, C., Adams, J., Defronzo, R. A. & Abdul-ghani, M. A., Mar 22 2017, (Accepted/In press) In : Diabetologia. p. 1-8 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Determinants of the increase in ketone concentration during SGLT2 inhibition in NGT, IFG and T2DM patients

Al Jobori, H., Daniele, G., Adams, J., Cersosimo, E., Triplitt, C. L., Defronzo, R. A. & Abdul-ghani, M. A., Jun 1 2017, In : Diabetes, Obesity and Metabolism. 19, 6, p. 809-813 5 p.

Research output: Contribution to journalArticle

25 Scopus citations