5-Hydroxytryptophan-induced conditioned taste aversion to ethanol in the rat

Joseph E. Zabik, John D. Roache

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

This experiment was conducted to determine the efficacy of 5-HTP in producing conditioned taste aversions (CTAs) to ethanol in rats restricted to a one-hour daily access to fluid. Administration of 100 mg/kg of DL-5-HTP immediately following novel exposure to ethanol resulted in an aversion of such magnitude that some rats refused to consume the ethanol solution. Since ethanol was the only fluid available to these rats, they eventually died, presumably of dehydration. By comparison, LiCl administration also produced a CTA to ethanol, but no such persistent rejection was observed. Both 5-HTP and LiCl also produced CTAs when saccharin and tartaric acid solutions were used as novel fluids, but these aversions were short-lived and all rats resumed drinking. The causative factor(s) in the persistent ethanol rejection until death observed in rats treated with 5-HTP remain undetermined but the results have indicated that simple CS-UCS associative learning mechanisms are probably not a primary causative factor.

Original languageEnglish (US)
Pages (from-to)785-790
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume18
Issue number5
DOIs
StatePublished - May 1983
Externally publishedYes

Keywords

  • 5-HTP
  • Conditioned taste aversion
  • Ethanol
  • LiCl
  • Novel fluids
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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