5α-Dihydrotestosterone Administration Converts Indolamine Metabolism and Porphyrin Content of the Female Syrian Hamster Harderian Gland to the Male Type (42978)

Benito Marrufo, Armando Menendez-Pelaez, Gerald R. Buzzell, Aldo Gonzalez-Brito, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism of Syrian hamster Harderian glands were studied. Ovariectomy alone had no effect on any of the parameters analyzed. The administration of either testosterone or 5α-dihydrotestosterone increased the activity of N-acetyltransferase in the Harderian glands. However, androgen treatment failed to change the activity of hydroxyindole-O-methyltransferase. Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5α-dihydrotestosterone. The porphyrin content of the Harderian glands was dramatically depressed after the administration of either androgen. It is concluded that the Harderian glands of Syrian hamsters are under an androgenic control involving 5α-dihydrotestosterone.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume192
Issue number2
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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