5α-dihydrotestosterone administration converts indolamine metabolism and porphyrin content of the female Syrian hamster Harderian gland to the male type

B. Marrufo, A. Menendez-Pelaez, G. R. Buzzell, A. Gonzalez-Brito, Russel J Reiter

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism and Syrian hamster Harderian glands were studied. Ovariectomy alone had no effect on any of the parameters analyzed. The administration of either testosterone or 5α-dihydrotestosterone increased the activity of N-acetyltransferase in the Harderian glands. However, androgen treatment failed to change the activity of hydroxyindole-O-methyltransferase. Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5α-dihydrotestosterone. The porphyrin content of the Harderian glands was dramatically depressed after the administration of either androgen. It is concluded that the Harderian glands of Syrian hamsters are under an androgenic control involving 5α-dihydrotestosterone.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume192
Issue number2
StatePublished - 1989

Fingerprint

Harderian Gland
Dihydrotestosterone
Mesocricetus
Porphyrins
Metabolism
Androgens
Ovariectomy
Testosterone
Acetylserotonin O-Methyltransferase
Acetyltransferases
Melatonin
indolamine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

5α-dihydrotestosterone administration converts indolamine metabolism and porphyrin content of the female Syrian hamster Harderian gland to the male type. / Marrufo, B.; Menendez-Pelaez, A.; Buzzell, G. R.; Gonzalez-Brito, A.; Reiter, Russel J.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 192, No. 2, 1989, p. 192-195.

Research output: Contribution to journalArticle

@article{12c7d4cd45dc45be8397c88686dacfdc,
title = "5α-dihydrotestosterone administration converts indolamine metabolism and porphyrin content of the female Syrian hamster Harderian gland to the male type",
abstract = "The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism and Syrian hamster Harderian glands were studied. Ovariectomy alone had no effect on any of the parameters analyzed. The administration of either testosterone or 5α-dihydrotestosterone increased the activity of N-acetyltransferase in the Harderian glands. However, androgen treatment failed to change the activity of hydroxyindole-O-methyltransferase. Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5α-dihydrotestosterone. The porphyrin content of the Harderian glands was dramatically depressed after the administration of either androgen. It is concluded that the Harderian glands of Syrian hamsters are under an androgenic control involving 5α-dihydrotestosterone.",
author = "B. Marrufo and A. Menendez-Pelaez and Buzzell, {G. R.} and A. Gonzalez-Brito and Reiter, {Russel J}",
year = "1989",
language = "English (US)",
volume = "192",
pages = "192--195",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "Society for Experimental Biology and Medicine",
number = "2",

}

TY - JOUR

T1 - 5α-dihydrotestosterone administration converts indolamine metabolism and porphyrin content of the female Syrian hamster Harderian gland to the male type

AU - Marrufo, B.

AU - Menendez-Pelaez, A.

AU - Buzzell, G. R.

AU - Gonzalez-Brito, A.

AU - Reiter, Russel J

PY - 1989

Y1 - 1989

N2 - The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism and Syrian hamster Harderian glands were studied. Ovariectomy alone had no effect on any of the parameters analyzed. The administration of either testosterone or 5α-dihydrotestosterone increased the activity of N-acetyltransferase in the Harderian glands. However, androgen treatment failed to change the activity of hydroxyindole-O-methyltransferase. Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5α-dihydrotestosterone. The porphyrin content of the Harderian glands was dramatically depressed after the administration of either androgen. It is concluded that the Harderian glands of Syrian hamsters are under an androgenic control involving 5α-dihydrotestosterone.

AB - The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism and Syrian hamster Harderian glands were studied. Ovariectomy alone had no effect on any of the parameters analyzed. The administration of either testosterone or 5α-dihydrotestosterone increased the activity of N-acetyltransferase in the Harderian glands. However, androgen treatment failed to change the activity of hydroxyindole-O-methyltransferase. Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5α-dihydrotestosterone. The porphyrin content of the Harderian glands was dramatically depressed after the administration of either androgen. It is concluded that the Harderian glands of Syrian hamsters are under an androgenic control involving 5α-dihydrotestosterone.

UR - http://www.scopus.com/inward/record.url?scp=0024445995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024445995&partnerID=8YFLogxK

M3 - Article

C2 - 2813451

AN - SCOPUS:0024445995

VL - 192

SP - 192

EP - 195

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 2

ER -