TY - JOUR
T1 - 24R,25-dihydroxyvitamin D3 modulates tumorigenicity in breast cancer in an estrogen receptor-dependent manner
AU - Verma, Anjali
AU - Schwartz, Zvi
AU - Boyan, Barbara D.
N1 - Funding Information:
Services in support of the research project were provided by the VCU Massey Cancer Mouse Models Core, supported, in part, with funding from NIH-NCI Cancer Center Support Grant P30 CA016059.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D3], is associated with worsened cancer prognosis and decreased survival rates in cancer patients. However, clinical studies investigating the role of vitamin D supplementation in breast cancer treatment are largely inconclusive. One reason for this may be that many of these studies ignore the complexity of the vitamin D metabolome and the effects of these metabolites at the cellular level. Once ingested, vitamin D is metabolized into 37 different metabolites, including 25(OH)D3, which is the metabolite actually measured clinically, as well as 1,25(OH)2D3 and 24,25(OH)2D3. Recent work by our lab and others has demonstrated a role for 24R,25(OH)2D3, in the modulation of breast cancer tumors via an estrogen receptor α-dependent mechanism. This review highlights the importance of considering estrogen receptor status in vitamin D-associated prognostic studies of breast cancer and proposes a potential mechanism for 24R,25(OH)2D3 signaling in breast cancer cells.
AB - Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D3], is associated with worsened cancer prognosis and decreased survival rates in cancer patients. However, clinical studies investigating the role of vitamin D supplementation in breast cancer treatment are largely inconclusive. One reason for this may be that many of these studies ignore the complexity of the vitamin D metabolome and the effects of these metabolites at the cellular level. Once ingested, vitamin D is metabolized into 37 different metabolites, including 25(OH)D3, which is the metabolite actually measured clinically, as well as 1,25(OH)2D3 and 24,25(OH)2D3. Recent work by our lab and others has demonstrated a role for 24R,25(OH)2D3, in the modulation of breast cancer tumors via an estrogen receptor α-dependent mechanism. This review highlights the importance of considering estrogen receptor status in vitamin D-associated prognostic studies of breast cancer and proposes a potential mechanism for 24R,25(OH)2D3 signaling in breast cancer cells.
KW - 24R,25-dihydroxyvitamin D
KW - Breast cancer
KW - Estrogen receptor α
KW - Phospholipase D
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85069479297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069479297&partnerID=8YFLogxK
U2 - 10.1016/j.steroids.2019.108447
DO - 10.1016/j.steroids.2019.108447
M3 - Article
C2 - 31302113
AN - SCOPUS:85069479297
VL - 150
JO - Steroids
JF - Steroids
SN - 0039-128X
M1 - 108447
ER -