TY - JOUR
T1 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
T2 - Potent anticarcinogenic activity in CD-1 mice
AU - DiGiovanni, John
AU - Berry, David L.
AU - Juchau, Mont R.
AU - Slaga, Thomas J.
N1 - Funding Information:
1 Supported by grants HD-04839 from the National Institute of Child Health and Human Development, U. S.P. H. S., National Institutes of Health, U.S. P. H. S. Training Grant GM -00109, by Grant CA-20076 from the National Cancer Institute, U. S. P. H. S. and by the U. S. Department of Energy under contract W-7405-eng-26 with the Union Carbide Corporation.
PY - 1979/2/14
Y1 - 1979/2/14
N2 - Topical pretreatment with non-toxic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant formed in the commercial synthesis of the herbicide 2,4,5-trichlorophen-oxyacetic acid, strongly inhibited the initiation of skin tumors by 7,12-dimethylbenz(a)-anthracene and benzo(a)pyrene in female CD-1 mice. 2,3,7,8-tetrachlorodibenzo-p-dioxin also produced marked induction of epidermal monooxygenase enzymes functional in the conversion of 7,12-dimethylbenz(a)anthracene to a variety of hydroxylated products. The time course of anticarcinogenic effects resulting from pretreatment with the dioxin correlated with the magnitude of induction as well as with a singnificant reduction in the quantity of 7,12-dimethylbenz(a)anthracene metabolites covalently bound in vivo to epidermal DNA and RNA but not protein.
AB - Topical pretreatment with non-toxic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant formed in the commercial synthesis of the herbicide 2,4,5-trichlorophen-oxyacetic acid, strongly inhibited the initiation of skin tumors by 7,12-dimethylbenz(a)-anthracene and benzo(a)pyrene in female CD-1 mice. 2,3,7,8-tetrachlorodibenzo-p-dioxin also produced marked induction of epidermal monooxygenase enzymes functional in the conversion of 7,12-dimethylbenz(a)anthracene to a variety of hydroxylated products. The time course of anticarcinogenic effects resulting from pretreatment with the dioxin correlated with the magnitude of induction as well as with a singnificant reduction in the quantity of 7,12-dimethylbenz(a)anthracene metabolites covalently bound in vivo to epidermal DNA and RNA but not protein.
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U2 - 10.1016/0006-291X(79)91752-2
DO - 10.1016/0006-291X(79)91752-2
M3 - Article
C2 - 106852
AN - SCOPUS:0018348547
SN - 0006-291X
VL - 86
SP - 577
EP - 584
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -