TY - JOUR
T1 - 1,25(OH)2D3 is not the only D metabolite involved in the pathogenesis of osteomalacia
AU - Rasmussen, Howard
AU - Baron, Roland
AU - Broadus, Arthur
AU - DeFronzo, Ralph
AU - Lang, Robert
AU - Horst, Ronald
N1 - Funding Information:
ROLAND BARON, M.D. ARTHUR BROADUS. M.D. RALPH DeFRONZO, M.D. ROBERT LANG, M.D. New Haven, Connecticut RONALD HORST, M.D. Ames, lowo From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut: and the U.S. Department of Agriculture Scientific and Educational Administration, Ames, Iowa. This work was supported by an NIH SCOR Grant [AM 20570). Clinical studies were performed in the Clinical Research Center of the Yale-New Haven Hospital and were supported by a grant (RP-1251 from the General Clinical Research Centers Branch, Division of Research Resources, NIH. Requests for reprints should be addressed to Dr. Howard Rasmussen, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510. Manuscript accepted March 17,198O.
PY - 1980
Y1 - 1980
N2 - Three patients are described in whom there was no simple correlation between plasma 1,25(OH)2D3 concentration and the occurrence of osteomalacia. One patient had severe osteomalacia with high plasma 1,25(OH)2D3 and normal mineral ion product; the second had a normal mineral ion product and no evidence of osteomalacia even though plasma 1,25(OH)2D3 was undetectable; and the third had osteomalacia, low plasma 1,25(OH)2D3 and a reduced mineral ion product. In considering these data in the light of presently available information, it is concluded that osteomalacia can occur as a consequence of a lack of a vitamin D metabolite other than 1,25(OH)2D3, or as a consequence of a reduced mineral ion product, but not as a consequence of 1,25(OH)2D3 lack if the mineral ion product is normally maintained and other D metabolites are present. However, a deficiency of 1,25(OH)2D3 normally leads to a reduction in the mineral ion product hence 1,25(OH)2D3 deficiency may play a role in the development of certain forms of osteomalacia.
AB - Three patients are described in whom there was no simple correlation between plasma 1,25(OH)2D3 concentration and the occurrence of osteomalacia. One patient had severe osteomalacia with high plasma 1,25(OH)2D3 and normal mineral ion product; the second had a normal mineral ion product and no evidence of osteomalacia even though plasma 1,25(OH)2D3 was undetectable; and the third had osteomalacia, low plasma 1,25(OH)2D3 and a reduced mineral ion product. In considering these data in the light of presently available information, it is concluded that osteomalacia can occur as a consequence of a lack of a vitamin D metabolite other than 1,25(OH)2D3, or as a consequence of a reduced mineral ion product, but not as a consequence of 1,25(OH)2D3 lack if the mineral ion product is normally maintained and other D metabolites are present. However, a deficiency of 1,25(OH)2D3 normally leads to a reduction in the mineral ion product hence 1,25(OH)2D3 deficiency may play a role in the development of certain forms of osteomalacia.
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U2 - 10.1016/0002-9343(80)90005-4
DO - 10.1016/0002-9343(80)90005-4
M3 - Article
C2 - 6251721
AN - SCOPUS:0018855530
SN - 0002-9343
VL - 69
SP - 360
EP - 368
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 3
ER -