1 The immune system in health and disease

Donald J. Dudley

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


For an immune response against an eliciting antigen, innate and adaptive immune mechanisms interact to provide a specific and appropriate response characterized by self-non-self discrimination and memory. This nonrandom process involves antigen presentation followed by T cell recognition and activation with the elaboration of T cell-derived lymphokines. The nature and amount of lymphokine production from antigen-activated T cells then determines the predominant immune response (e.g. cytotoxicity versus antibody). Exogenous regulatory factors, including steroid hormones, prostaglandins, and cytokines, modulate immune responsiveness. How these regulatory factors influence the immune response during specific host-parasite interactions determines the predominant immune response to specific antigen. As the regulation of the immune response is unravelled, new and powerful immunomodulatory therapies will be developed and utilized to improve the immune response and host survival.

Original languageEnglish (US)
Pages (from-to)393-416
Number of pages24
JournalBailliere's Clinical Obstetrics and Gynaecology
Issue number3
StatePublished - Sep 1992
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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