Δ1 Tetrahydrocannabinol, cannabidiol and cannabinol effects on the immune response of mice

S. Zimmerman, A. M. Zimmerman, I. L.H.L. Cameron

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Δ1 Tetrahydrocannabinol (THC) elicited a dose dependent (1, 5, 10 mg/kg) depression of the immune response, of immature mice, stimulated with sheep red blood cells. The impairment of humoral immunity was specific for THC but not for cannabidiol at 25 mg/kg or cannabinol at 25 mg/kg. The mice were given four daily doses (i.p.) of either drug or vehicle (Tween 80 propylene glycol in 1% saline) or a single injection (i.p.) of sheep red blood cells in addition to four daily doses (i.p.) of drug or vehicle. Suppression of the antigenic response by THC was reflected as a reduction of splenic weight, reduction in the number of splenic antibody forming cells, lowered hemagglutination titer and reduction in the percentage of splenic white pulp to total spleen volume.

Original languageEnglish (US)
Pages (from-to)10-23
Number of pages14
JournalPharmacology
Volume15
Issue number1
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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