δ scores predict mild cognitive impairment and Alzheimer's disease conversions from nondemented states

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6 Citations (Scopus)

Abstract

Introduction We tested the latent variable “δ” (for “dementia”)s ability to predict conversion to “mild cognitive impairment” (MCI) and Alzheimer's disease (AD). Methods An ethnicity equivalent d homolog (“dEQ”) was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. “Normal Controls” (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)]. Results 22.0% (n = 281) of NC converted to “MCI” or “AD”. 17.3%(n = 106) of MCI converted to “AD.” Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52%. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. Discussion Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.

Original languageEnglish (US)
Pages (from-to)214-221
Number of pages8
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume6
DOIs
StatePublished - 2017

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Alzheimer Disease
Aptitude
Dementia
Cognitive Dysfunction
Research

Keywords

  • Aging
  • Cognition
  • Dementia
  • Functional status
  • g
  • Intelligence
  • MCI

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

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title = "δ scores predict mild cognitive impairment and Alzheimer's disease conversions from nondemented states",
abstract = "Introduction We tested the latent variable “δ” (for “dementia”)s ability to predict conversion to “mild cognitive impairment” (MCI) and Alzheimer's disease (AD). Methods An ethnicity equivalent d homolog (“dEQ”) was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. “Normal Controls” (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)]. Results 22.0{\%} (n = 281) of NC converted to “MCI” or “AD”. 17.3{\%}(n = 106) of MCI converted to “AD.” Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52{\%}. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. Discussion Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.",
keywords = "Aging, Cognition, Dementia, Functional status, g, Intelligence, MCI",
author = "Royall, {Donald R} and Ray Palmer",
year = "2017",
doi = "10.1016/j.dadm.2017.02.002",
language = "English (US)",
volume = "6",
pages = "214--221",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - δ scores predict mild cognitive impairment and Alzheimer's disease conversions from nondemented states

AU - Royall, Donald R

AU - Palmer, Ray

PY - 2017

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N2 - Introduction We tested the latent variable “δ” (for “dementia”)s ability to predict conversion to “mild cognitive impairment” (MCI) and Alzheimer's disease (AD). Methods An ethnicity equivalent d homolog (“dEQ”) was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. “Normal Controls” (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)]. Results 22.0% (n = 281) of NC converted to “MCI” or “AD”. 17.3%(n = 106) of MCI converted to “AD.” Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52%. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. Discussion Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.

AB - Introduction We tested the latent variable “δ” (for “dementia”)s ability to predict conversion to “mild cognitive impairment” (MCI) and Alzheimer's disease (AD). Methods An ethnicity equivalent d homolog (“dEQ”) was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. “Normal Controls” (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)]. Results 22.0% (n = 281) of NC converted to “MCI” or “AD”. 17.3%(n = 106) of MCI converted to “AD.” Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52%. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. Discussion Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.

KW - Aging

KW - Cognition

KW - Dementia

KW - Functional status

KW - g

KW - Intelligence

KW - MCI

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