Abstract
Introduction We tested the latent variable “δ” (for “dementia”)s ability to predict conversion to “mild cognitive impairment” (MCI) and Alzheimer's disease (AD). Methods An ethnicity equivalent d homolog (“dEQ”) was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. “Normal Controls” (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)]. Results 22.0% (n = 281) of NC converted to “MCI” or “AD”. 17.3%(n = 106) of MCI converted to “AD.” Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52%. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. Discussion Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.
Original language | English (US) |
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Pages (from-to) | 214-221 |
Number of pages | 8 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 6 |
DOIs | |
State | Published - 2017 |
Keywords
- Aging
- Cognition
- Dementia
- Functional status
- Intelligence
- MCI
- g
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health