γδ T-cells: Potential regulators of the post-burn inflammatory response

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Severe burn induces an immunopathological response that contributes to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, γδ T-cells are central in the response to injury. While γδ T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn. This review will focus on the potential regulator role of γδ T-cells in immunopathological response following burn and thereby their potential as therapeutic targets for affecting inflammation and healing.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalBurns
Volume35
Issue number3
DOIs
StatePublished - May 1 2009

Keywords

  • Bisphosphonates
  • Chemokines
  • Growth factors
  • Organ injury
  • Wound healing

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'γδ T-cells: Potential regulators of the post-burn inflammatory response'. Together they form a unique fingerprint.

Cite this