β2-Adrenergic receptor ablation modulates hepatic lipid accumulation and glucose tolerance in aging mice

Yun Shi, Zhen Ju Shu, Xiaoling Xue, Chih-ko Yeh, Michael S. Katz, Amrita Kamat

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Catecholamines acting through β-adrenergic receptors (β1-, β2-, β3-AR subtypes) modulate important biological responses in various tissues. Our previous studies suggest a role for increased hepatic β-AR-mediated signaling during aging as a mediator of hepatic steatosis, liver glucose output, and insulin resistance in rodents. In the current study, we have utilized β2-AR knockout (KO) and wildtype (WT) control mice to define further the role of β2-AR signaling during aging on lipid and glucose metabolism. Our results demonstrate for the first time that age-related increases in hepatic triglyceride accumulation and body weight are attenuated upon β2-AR ablation. Although no differences in plasma triglyceride, non-esterified fatty acids or insulin levels were detected between old WT and KO animals, an age-associated increase in hepatic expression of lipid homeostasis regulator Cidea was significantly reduced in old KO mice. Interestingly, we also observed a shift from reduced glucose tolerance in young adult KO animals to significantly improved glucose tolerance in old KO when compared to age-matched WT mice. These results provide evidence for an important role played by β2-ARs in the regulation of lipid and glucose metabolism during aging. The effect of β2-AR ablation on caloric intake during aging is currently not known and requires investigation. Future studies are also warranted to delineate the β2-AR-mediated mechanisms involved in the control of lipid and glucose homeostasis, especially in the context of a growing aging population.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalExperimental Gerontology
Volume78
DOIs
StatePublished - Jun 1 2016

Keywords

  • Cide
  • Hepatocytes
  • Lipid
  • Metabolism
  • Nonalcoholic fatty liver disease
  • Triglycerides

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

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