β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Elaine D. Por, Sonya M. Bierbower, Kelly A. Berg, Ruben Gomez, Armen N. Akopian, William C. Wetsel, Nathaniel A. Jeske

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

Original languageEnglish (US)
Pages (from-to)37552-37563
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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