β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Elaine D. Por; Sonya M. Bierbower; Kelly A. Berg; Ruben Gomez; Armen N. Akopian; William C. Wetsel; Nathaniel A. Jeske

doi:10.1074/jbc.M112.391847

β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Elaine D. Por, Sonya M. Bierbower, Kelly A. Berg, Ruben Gomez, Armen N. Akopian, William C. Wetsel, Nathaniel A. Jeske

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

Original language	English (US)
Pages (from-to)	37552-37563
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.391847
State	Published - Oct 26 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel",

abstract = "Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.",

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doi = "10.1074/jbc.M112.391847",

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AU - Por, Elaine D.

AU - Bierbower, Sonya M.

AU - Berg, Kelly A.

AU - Gomez, Ruben

AU - Akopian, Armen N.

AU - Wetsel, William C.

AU - Jeske, Nathaniel A.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

AB - Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

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β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Abstract

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