β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

Chih Ko Yeh; John M. Louis; Eleni E. Kousvelari

doi:10.1016/0014-5793(88)80351-X

β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

Chih Ko Yeh, John M. Louis, Eleni E. Kousvelari

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.

Original language	English (US)
Pages (from-to)	118-122
Number of pages	5
Journal	FEBS Letters
Volume	240
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(88)80351-X
State	Published - Nov 21 1988
Externally published	Yes

Keywords

(RSMT-A5)
Epithelia
Protooncogene c-fos
cyclic AMP
β-Adrenoreceptor

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(88)80351-X

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title = "β-Adrenergic regulation of c-fos gene expression in an epithelial cell line",

abstract = "Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.",

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AU - Louis, John M.

AU - Kousvelari, Eleni E.

PY - 1988/11/21

Y1 - 1988/11/21

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AB - Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.

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