β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

Chih Ko Yeh, John M. Louis, Eleni E. Kousvelari

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalFEBS Letters
Volume240
Issue number1-2
DOIs
StatePublished - Nov 21 1988
Externally publishedYes

Keywords

  • (RSMT-A5)
  • Epithelia
  • Protooncogene c-fos
  • cyclic AMP
  • β-Adrenoreceptor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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