β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

Chih Ko Yeh; John M. Louis; Eleni E. Kousvelari

doi:10.1016/0014-5793(88)80351-X

β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

Chih Ko Yeh, John M. Louis, Eleni E. Kousvelari

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.

Original language	English (US)
Pages (from-to)	118-122
Number of pages	5
Journal	FEBS Letters
Volume	240
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(88)80351-X
State	Published - Nov 21 1988
Externally published	Yes

Keywords

(RSMT-A5)
Epithelia
Protooncogene c-fos
cyclic AMP
β-Adrenoreceptor

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(88)80351-X

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title = "β-Adrenergic regulation of c-fos gene expression in an epithelial cell line",

abstract = "Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.",

keywords = "(RSMT-A5), Epithelia, Protooncogene c-fos, cyclic AMP, β-Adrenoreceptor",

author = "Yeh, {Chih Ko} and Louis, {John M.} and Kousvelari, {Eleni E.}",

note = "Funding Information: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 and + Division of Cancer Biology and Diagnosis, National Cancer institute, National Institutes of Health, Bethesda, MD 20892, USA",

year = "1988",

month = nov,

day = "21",

doi = "10.1016/0014-5793(88)80351-X",

language = "English (US)",

volume = "240",

pages = "118--122",

journal = "FEBS Letters",

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publisher = "Elsevier",

number = "1-2",

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TY - JOUR

T1 - β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

AU - Yeh, Chih Ko

AU - Louis, John M.

AU - Kousvelari, Eleni E.

N1 - Funding Information: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 and + Division of Cancer Biology and Diagnosis, National Cancer institute, National Institutes of Health, Bethesda, MD 20892, USA

PY - 1988/11/21

Y1 - 1988/11/21

N2 - Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.

AB - Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.

KW - (RSMT-A5)

KW - Epithelia

KW - Protooncogene c-fos

KW - cyclic AMP

KW - β-Adrenoreceptor

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JF - FEBS Letters

SN - 0014-5793

IS - 1-2

ER -

β-Adrenergic regulation of c-fos gene expression in an epithelial cell line

Abstract

Keywords

ASJC Scopus subject areas

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