Abstract
Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 118-122 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 240 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 21 1988 |
| Externally published | Yes |
Keywords
- (RSMT-A5)
- Epithelia
- Protooncogene c-fos
- cyclic AMP
- β-Adrenoreceptor
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Cite this
Yeh, C. K., Louis, J. M., & Kousvelari, E. E. (1988). β-Adrenergic regulation of c-fos gene expression in an epithelial cell line. FEBS Letters, 240(1-2), 118-122. https://doi.org/10.1016/0014-5793(88)80351-X