Abstract
Stimulation of β-adrenoreceptors in the RSMT-A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto-oncogene c-fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8-bromo-cAMP. The induction of c-fos is specific since the expression of p53, a transformation-related gene, is not modulated by isoproterenol or 8-bromo-cAMP. The increase in c-fos gene expression is not associated with proliferative activity in these epithelial cells.
Original language | English (US) |
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Pages (from-to) | 118-122 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 240 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 21 1988 |
Externally published | Yes |
Keywords
- (RSMT-A5)
- Epithelia
- Protooncogene c-fos
- cyclic AMP
- β-Adrenoreceptor
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology