β-Adrenergic receptor changes in learned helplessness may depend on stress and test parameters

Stephen K. Brannan, Alexander Miller, David J. Jones, Gerald L. Kramer, Frederick Petty

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Behavioral deficits following inescapable stress (learned helplessness) may serve as an animal model of depression. Previous studies using foot-shock stress to induce learned helplessness and a bar-press test for the stress-induced behavioral deficit have found increased β-adrenergic receptor density in the hippocampus of learned helpless rats. We replicated these experiments using a tail-shock stress and the shuttle-box test. In our experiments, rats that developed learned helplessness after inescapable stress did not demonstrate any significant differences in β-adrenergic receptor density or affinity in the frontal cortex, cerebellum, or hippocampus compared to the nonhelpless rats, nor to the tested control rats. These results suggest that β-adrenergic receptor changes in learned helplessness may depend on the specific stress and test procedures used.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume51
Issue number2-3
DOIs
StatePublished - Jan 1 1995

Keywords

  • Animal models
  • Depression
  • Learned helplessness
  • Norepinephrine
  • β-Adrenergic receptor

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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