α-Fetoprotein levels in amniotic fluid between 11 and 15 weeks

Barbara F. Crandall, Frederick W. Hanson, Frances Tennant, Sondra T. Perdue

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We have shown that α-fetoprotein levels in amniotic fluid peak at 13 weeks and then fall by about 10% a week until 20 weeks. Use of cutoff levels obtained by extrapolation backward from medians at later dates gives results that are too high and could cause diagnostic errors. The ability to monitor α-fetoprotein levels accurately provides an advantage to this method of early prenatal diagnosis.

Original languageEnglish (US)
Pages (from-to)1204-1206
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume160
Issue number5 PART 1
DOIs
StatePublished - May 1989
Externally publishedYes

Keywords

  • Amniocentesis
  • amniotic fluid
  • fetal serum
  • α-fetoprotein

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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