ß-Adrenergic stimulation prior to darkness advances the nocturnal increase of Syrian hamster pineal melatonin synthesis

A. Gonzalez-Brito, R. J. Reiter, C. Santana, A. Menedez-Pelaez, J. M. Guerrero

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13 Scopus citations


Pineal glands of male Syrian hamsters stimulated in vivo with isoproterenol (ISO) for 4 h before the onset of darkness showed at 4-h advance in the timing of the nighttime increases in both N-acetyltransferase activity and melatonin levels. When ISO (1 mg/kg) was administered every 2 h to animals kept in light during the night, a significant increase in melatonin synthesis was observed after 4-6 h. The results suggest that the Syrian hamster pineal gland can respond in vivo to continuous ß-adrenergic stimulation, but a lag period of 4-6 h is required before there is an increase in melatonin synthesis.

Original languageEnglish (US)
Pages (from-to)393-396
Number of pages4
JournalBrain Research
Issue number2
StatePublished - Dec 20 1988



  • Isoproterenol
  • Melatonin
  • N-acetyltransferase activity
  • Pineal gland
  • Syrian hamster

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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