SCHISTOSOMIASIS AND CHAGAS DISEASE IN BRAZIL

  • Loverde, Philip T (PI)
  • Kemp, W. Michael (PI)
  • Romanha, Alvaro J. (PI)
  • Gazzinelli, Giovanni (PI)
  • Colley, Daniel G. (PI)
  • Carter, Clint (PI)
  • Carter, Clint (PI)
  • De Oliveira, Rodrigo (PI)
  • Doughty, Barbara (PI)

Project: Research project

Project Details

Description

We propose to build a research program of interdisciplinary studies on
human schistosomiasis mansoni and Chagas' disease in Minas Gerias, Brazil.
The disciplines will include immunology, molecular biology, biochemistry,
pathology, epidemiology and clinical medicine. This program is rooted in
the collaborative research being pursued in schistosomal immunoregulation
by 3 of the senior investigators on this application. Our goals are to
understand the pathogenesis of these diseases, and develop vaccines or
other modalities to control the morbidity and mortality of these
infections. Studies on the immunoregulation of schistosomiasis:
comparisons of T cell clones/hybridomas from patients with different
clinical forms, and their abilities to induce/regulate in vitro granuloma
formation; comparisons of multi/monoclonal anti-schistosome idiotypes (Ids)
from patients in clinical groups. Schistosomal pathogenesis: ability of
patients to stimulate/regulate fibrogenesis, and to produce fibrogenic
extracellular matrix proteins, at the protein and gene activation levels.
Studies on the immunology of Chagas' disease: cellular immune responses
and regulation in patients with different clinical forms of Chagas'
disease; Id analysis of patients' anti-T. cruzi antibodies and
retrospective and longitudinal studies of maternal/perinatal immune effects
on subsequent responsiveness, morbidity and mortality; autoimmune studies
and HLA-typing, with analysis in relationship to clinical patterns.
Studies of the Molecular Biology of S. mansoni: identification, cloning
and production of parasite encoded antigens useful in both diagnosis and
immunoregulatory studies of schistosomiasis. Studies of the Molecular
Biology of T cruzi: identification, cloning and production of parasite
encoded antigens related to patients' cellular immunity and useful in
diagnosis of Chagas' disease, and potentially involved in cross-reactivity
and autoimmune reactions with host tissues.
StatusFinished
Effective start/end date5/1/898/31/00

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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