• German, Victor F (PI)
  • Coalson, Jacqueline J (PI)
  • Harris, Gary (PI)
  • King, Richard (PI)
  • Kolb, William (PI)
  • Collins, James (PI)
  • Levine, Shirley (PI)
  • Johanson, Waldemar (PI)

Project: Research project

Project Details


This project is a multidisciplinary approach to the problem of acute respiratory
failure due to diffuse alveolar damage. Inflammatory mechanisms may initiate
lung injury in some circumstances or may become activated by lung injury in
others, thus serving to potentiate injury begun by other processes. We will
examine the roles of complement and neutrophils in each of these circumstances
using the technique of bronchoalveolar lavage to sample the alveolar milieu.
Connective tissue accumulation occurs rapidly in the lungs of some patients with
diffuse alveolar damage and probably contributes to the high mortality of the
syndrome. We are analyzing connective tissue responses of humans and
experimental animals with a variety of lung injuries, some of which lead to
fibrosis and some which do not to define factors which are important
determinants of connective tissue accumulation. Atelectasis is a common feature
of diffuse alveolar damage but its role in the evaluation of the injury is not
clear. We are investigating the changes in the lung's microvasculature in
atelectasis using electron microscopy and various tracer molecules. Bacterial
infection of the lung is a common complication of acute respiratory failure
which contributes significantly to the morbidity of the syndrome. We are
investigating the mechanisms whereby pathogenic bacteria are able to colonize
the respiratory tract. The effects of bacterial products on lung cells in vivo
and in vitro are being studied.
Effective start/end date12/1/7811/30/89


  • National Institutes of Health


  • Medicine(all)


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