• Bowden, Charles L (PI)

Project: Research project

Project Details


The major aim of this six-center collaborative study was to test
hypotheses which implicate neurobiological mechanisms in the
etiology and maintenance of the affective disorders. This
collaborative approach was developed in order to provide a
consortium of investigators having expertise in diverse disciplines
to design and conduct the research. The study utilized uniform
diagnostic criteria and behavioral methods, so as to assess the
functioning of multiple biological systems in the same subjects. It
provided for assessment during a baseline drug-free period and
after four weeks of antidepressant drug treatment. This
collaborative effort makes it possible to test earlier and current
hypotheses, and to examine interactions across and among
biological systems and behavior. All data analysis and the initial phase of hypothesis testing have
been essentially completed. This grant application represents a
request for a final period of support during which the second
phase of the testing of hypotheses which involve two or more
biological systems and behavior, will be brought to a conclusion.
Effective start/end date8/1/887/31/93


  • National Institutes of Health: $39,267.00


  • Medicine(all)


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