NEW MODEL FOR HUMAN DISEASES

  • Rainwater, David L (PI)
  • VandeBerg, John L (PI)
  • Hubbard, Gene (PI)
  • Henkel, Richard (PI)
  • Kammerer, Candace (PI)
  • Samollow, Paul (PI)
  • Robinson, Edward (PI)

    Project: Research project

    Project Details

    Description

    This research program will lead to the establishment of the laboratory
    opossum (Monodelphis domestica) as a unique and appropriate mammal model
    for research on a variety of human diseases of importance to public
    health. We propose to initiate six interactive investigations that will
    form the basis for future large scale studies on susceptibility to human
    diseases (broadly classified as cancer and cardiovascular disease) and
    on their initiation, progression, and treatment. Furthermore, we expect
    that during the proposed period of this program, pilot studies using
    Monodelphis as a model for investigating human infectious disease and
    human fetal development will advance to the level of major research
    initiatives. The use of Monodelphis as an experimental mammal model facilitates the
    detection of genetic effects and interactions involved in specific
    diseases that may be difficult to identify in affect humans. The results
    of these investigations can lead to new hypotheses that can be tested
    with human subjects. Conversely, Monodelphis has a great deal of
    potential for testing hypotheses that arise from research on these
    diseases in humans, but can be tested only on a animal model. Project
    1 will enhance the incidence, determine the progression, and generate
    data for genetic analysis of susceptibility to malignant melanoma,
    initiated at the suckling stage in Monodelphis by exposure to ultraviolet
    radiation alone. Project 2 will test the hypothesis that angiogenesis
    is a prerequisite for ultraviolet radiation-inducted mesenchymal
    neoplasia, using the corneal stroma in Monodelphis as a model system.
    Project 3 will determine the effectiveness of specific chemotherapeutic
    strategies, applicable to humans, for treatment of malignant melanoma and
    mesenchymal (corneal) neoplasia of Monodelphis, using in vitro and in
    vivo systems. Project 4 will examine the effects of diet and genotype
    on lipoprotein phenotypes and the initiation and progression of
    atherosclerosis in the Mondelphis model. Project 5 will be determine the
    genetic basis of serum cholesterol response to a high-cholesterol,
    saturated fat diet in Monodelphis, with the long-term goal, together with
    Project 4, of identifying specific genes that control dietary
    responsiveness. Project 6 will establish a basic linkage map of the
    Monodelphis genome and will use this map to identify associations between
    specific alleles and the phenotypes of interest in the other projects.
    The six Projects are supported by a Core Unit for animal resource
    management, data management and analysis, various research services, and
    administration.
    StatusFinished
    Effective start/end date8/1/947/31/00

    Funding

    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health

    ASJC

    • Medicine(all)

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