NEUROMUSCULAR IMMUNOPATHOLOGY IN EAMG

Project: Research project

Project Details

Description

The immunopathology of Experimental Autoimmune Myasthenia
Gravis (EAMG) in rats involves a neuromuscular impairment
caused by a T cell-dependent antibody response produced against
the post-junctional acetylcholine receptor (AChR). The result is
weakness and rapid fatiguing in the rats similar to symptoms
observed in human patients inflicted with myasthenia gravis.
Although much information is known concerning the
immunopathological role of AChR-reactive B cells (and the
antibodies that they produce), much less is understood concerning
the exact nature of AChR-reactive T cells. Furthermore, there is
a paucity of information regarding effects of anti-AChR immune
responses on neuromuscular signals resulting in muscle
contraction. Thus, the goals of the proposed studies are to
determine the influence of helper T cell specificity on subsequent
anti-AChR antibody production and ultimately, the influence of
helper T cell specificity on the induction of disease symptoms. A
thorough understanding of the T cell regulation of this
autoimmune antibody response may allow the development of
immunotherapeutic strategies that augment or place currently in
use.
StatusFinished
Effective start/end date7/1/879/29/93

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Neuroscience(all)

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