MOLECULARLY DEFINED VACCINE FOR SCHISTOSOMIASIS

  • Loverde, Philip T (PI)

Project: Research project

Project Details

Description

The major goal of the proposed research is to evaluate the vaccine
potential of specific schistosome molecules. to accomplish this goal we
will take advantage of the fact that in concomitant or attenuated parasite
immunity, there are species of antibody molecules that recognize
determinants on the surface of the schistosomule that mediate a
schistosomicidal response. These antibodies provide appropriate reagents
for isolating relevant antigens, when used in conjunction with recombinant
DNA technology. By isolating the DNA encoding an important antigen,
produce reasonable quantities of the antigen in prokaryotic or eukaryotic
vectors for vaccine testing or create a modified antigen that may function
even better than the native one in producing immunity. A second strategy will be to take advantage of the fact that may protective
monoclonal and polyclonal antibodies recognize carbohydrate epitopes.
These protective antibodies will be used to make hybridoma-derived anti-
idiotypic antibodies that mimic the carbohydrate epitope. By assessing the
efficacy of identified antigens or anti-idiotype antibodies in protection
experiments we will be able to identify those schistosome molecules that
are potential vaccine candidates.
StatusFinished
Effective start/end date4/1/833/31/11

Funding

  • National Institutes of Health: $344,521.00
  • National Institutes of Health: $308,753.00
  • National Institutes of Health
  • National Institutes of Health: $188,774.00
  • National Institutes of Health: $359,739.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $235,672.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $299,761.00
  • National Institutes of Health: $318,016.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $196,078.00
  • National Institutes of Health: $344,854.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $349,033.00
  • National Institutes of Health
  • National Institutes of Health: $349,912.00

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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