MOLECULAR BIOLOGY OF AN RNA VIRUS FOUND IN LEISHMANIA

  • Patterson, Jean L (PI)

    Project: Research project

    Project Details

    Description

    The purpose of this study is to continue to characterize a virus we have
    discovered in Leishmania braziliensis. Leishmania is an important human
    pathogen, the causative agent of leishmaniasis. The study of
    bacteriophages and viruses has provided important leads in our
    understanding of the control of gene expression, RNA processing and
    translation. These considerations highlight the potential value of a
    Leishmania virus for the study of unique gene regulation and expression
    mechanisms in kinetoplastid parasites. Specifically we would propose to:
    1) Begin to understand the intimate relationship of the virus with the
    parasite. 2) Continue to investigate the replicative and translational
    strategy of the virus. 3) Attempt to infect other strains of Leishmania.
    4) Use this virus as a vector. 5) Exploit this system as an experimental
    model for studying the translational mechanisms of Leishmania.
    StatusFinished
    Effective start/end date4/1/929/29/98

    Funding

    • National Institutes of Health
    • National Institutes of Health: $253,442.00
    • National Institutes of Health
    • National Institutes of Health

    ASJC

    • Medicine(all)
    • Immunology and Microbiology(all)

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