• Loverde, Philip T (PI)

Project: Research project

Project Details


The purpose of this proposal is to provide shared computing facilities
needed for the analysis of protein and nucleic acid sequence and
structure. The system will be used by a group of 27 faculty currently
supervising 18 NIH grants. We are all members of CAMBI (the Center for
Advanced Molecular Biology and Immunology), a group of 50 faculty from
eight departments at SUNY/Buffalo with common interests in the application
of molecular techniques to biological problems. CAMBI is the sponsor and
proposed administrator of this grant. Our NIH grants (a total of
$6,204,370 in direct costs per year) support research including the
prevention of dental and sexually transmitted diseases, the molecular
basis of aging, protein turnover, protein folding, the nature of malignant
cells, and the fundamental processes of viral assembly and gene control.
The hardware which is being requested to establish these computing
facilities consists of (1) a VAX 4000 computer configured with mass
storage devices and appropriate amounts of memory and (2) two molecular
graphic workstations configured for communication with the VAX and
containing software for the analysis of protein and nucleic acid three-
dimensional structures. Resident on the VAX will be a suite of programs used for primary and
secondary structure analysis of proteins, DNA and RNA. This suite
encompasses the University of Wisconsin Genetics Computer Group Programs,
the Staden Programs, and all currently available protein, DNA and RNA
sequence data banks. These programs are state -of-the-art and form a
crucial part of the research efforts of all the major users. Remote access
to these programs and databases will be available to the major users by
University-supported DCA or ETHERNET connections. Along with three other existing workstations, the newly-purchased modeling
workstations will be networked to each other and to the VAX via ETHERNET.
Resident on the VAX will be the Cambridge and Brookhaven structure
databases, which will be accessible by network connections. Resident on
each workstation will be software for simple graphics analysis of
biological macromolecules. Access to molecular mechanics programs resident
on one machine will be obtained through the network connection. The needed
power for these calculations can be obtained by the network-facilitated
utilization of each workstation's memory and computation power.
Effective start/end date9/30/933/29/95


  • National Institutes of Health: $173,000.00


  • Medicine(all)


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