• Cochran, David L (PI)
  • Bonewald, Lynda (PI)
  • Poser, James (PI)
  • Mundy, Gregory (PI)
  • Carnes, David (PI)
  • Yoneda, Toshiyuki (PI)
  • Holt, Stanley (PI)

Project: Research project

Project Details


This Program Project Grant application has been initiated in order to
utilize the expertise in our institution to clarify the mechanisms by which
bone cell function is disordered in diseases of the oral cavity. It is our
contention that the mechanisms by which disease process of the oral cavity
affect alveolar bone is by the generation of soluble factors which
stimulate bone cells. The specific aims of this application are to
identify the mechanisms by which disease processes in the oral cavity
affect bone resorbing and bone forming cells, and our plan is to use in
vitro techniques of cell culture and organ culture as well as in vivo
studies to assess the effects of potential mediators on bone resorption
and bone formation. These mechanisms and factors are heterogeneous, and
characterization of the pathophysiology of bone cell dysfunction in these
diseases will require a broadly-based approach. Since the expertise
required to identify and clarify these mechanisms will require the
attention of investigators with different types of skills, a team approach
will be used to unite these different approaches around the tightly focused
goal of clarifying the pathophysiology of bone cell dysfunction in diseases
of the oral cavity.
Effective start/end date1/1/8912/31/94


  • National Institutes of Health


  • Medicine(all)
  • Dentistry(all)


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