DESCRIPTION (provided by applicant): The overall objective of the present proposal is to develop, evaluate, distribute, and apply tools for quantitative meta-analysis of the human functional brain mapping (HFBM) literature. The BrainMap database may be used as an internet-based resource for retrieval, coding, and filtering papers that is required for an HFBM meta-analysis. BrainMap has been fully implemented in a multi-platform software environment (Java) and populated with >750 papers and > 3,000 experiments (>20% of the literature meeting our inclusion criteria). It is now proposed: to extend the functionality of coordinate-based, voxel- wise meta-analysis (CVM) (Aim 1); to extend network analysis of CVM datasets (Aim 2); to create optimal high-resolution brain templates for spatial normalization that are representative of large groups of subjects (Aim 3); and to develop methods for returning functional labels and metrics of label likelihood for any given anatomical coordinate and serve these labels through a function-label extension of the Talairach Daemon (Aim 4). In addition, we propose a structured data-sharing plan that will provide a formal means for sharing software tools, meta-analyses, a functional ontology, and coordinate data of the published HFBM literature. Addressing these aims will greatly advance the current status of meta-analysis in functional neuroimaging. The evaluations associated with each development will provide guidance for further development of tools and logistics.
|Effective start/end date||7/1/05 → 3/31/19|
- National Institutes of Health: $498,019.00
- National Institutes of Health: $564,350.00
- National Institutes of Health: $614,757.00
- National Institutes of Health: $512,706.00
- National Institutes of Health: $722,489.00
- National Institutes of Health: $498,203.00
- National Institutes of Health: $602,922.00
- National Institutes of Health: $658,731.00
- National Institutes of Health: $640,093.00
- National Institutes of Health: $693,899.00
- National Institutes of Health: $88,432.00
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