GENETIC ANALYSIS OF COMMON DISEASES--AN EVALUATION

  • Almasy, Laura A (PI)
  • MacCluer, Jean (PI)

    Project: Research project

    Project Details

    Description

    DESCRIPTION: The overall goal of this
    project is to evaluate methods for detecting and characterizing genetic
    effects on common diseases and their risk factors by statistical genetic
    analysis of family and population data. This goal will be pursued by: (1) Continuing the organization of the Genetic Analysis Workshops (GAWs).
    For each GAW, topics are chosen that are relevant to current analytical
    problems in genetic epidemiology and sets of real or computer-simulated
    data are distributed to investigators worldwide. Results of analyses are
    discussed and compared at a two day meeting. GAW8 will be held in 1992 and
    GAW9 in 1994. Planning and data distribution for GAW10 will be underway by
    the end of the requested period of support in 1996. (2) Conducting evaluations of methods of genetic analysis. Some questions
    concerning the strengths and limitations of methods of genetic analysis
    cannot be properly addressed in a workshop setting, for example, questions
    of power, sensitivity, specificity, and robustness of various methods.
    Using computer-simulated data, the following issues would be addressed as
    they apply to analysis of quantitative traits: (a) detecting the effects
    of two or more loci on a trait; and (b) detecting and characterizing
    genetic effects in the presence of genotype by environment interaction. (3) Distributing simulation programs, simulated data, and programs for
    genetic analysis for use by other investigators. As a byproduct of our
    efforts in generating data for the GAWs and in evaluating methods of
    genetic analysis, a variety of computer programs and simulated data sets
    have been generated that are useful to other investigators. These programs
    and data sets will be documented and made available.
    StatusFinished
    Effective start/end date4/1/837/31/17

    Funding

    • National Institutes of Health: $586,925.00
    • National Institutes of Health: $627,619.00
    • National Institutes of Health: $586,304.00
    • National Institutes of Health: $49,228.00
    • National Institutes of Health: $568,091.00
    • National Institutes of Health: $586,464.00
    • National Institutes of Health: $48,736.00
    • National Institutes of Health: $461,006.00

    ASJC

    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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