• Austad, Steven N (PI)
  • Preston, Bradley (PI)
  • Ladiges, Warren C. (PI)
  • Wallace, Douglas (PI)
  • Loeb, Lawrence (PI)
  • Monnat, Raymond (PI)
  • Liggitt, Dennis (PI)
  • Martin, George (PI)
  • Rabinovitch, Peter (PI)

Project: Research project

Project Details


Genetic concepts and methodologies serve as the integrating themes for an
analysis of several basic phenomena of importance to gerontology. I. A) An
already well developed program of research on the in vitro clonal senescence of
normal mammalian somatic cells will couple somatic cell genetic investigations
with cell kinetic and biochemical analyses to determine the mechanisms limiting
the replicative potentials of cultured normal cells and the contrasts in cell
cycle regulation between normal cells, cells from patients with Werner syndrome,
and neoplastic cells. B) The in vivo clonal senescence of normal hematopoietic
cells will also be investigated. II. A newly emerging program of research
involving the use of cultured mouse teratocarcinoma cells for the genetic
analysis of in vivo aging will be expanded and will include efforts to carry out
several types of interspecific gene transfers. III. A newly proposed program
of comparative biogerontology, involving Mus musculus, Peromyscus leucopus and
Notomys alexis will be coupled with I and II above and will be utilized for
tests of the intrinsic mutagenesis and free-radical theories of aging.
Effective start/end date9/29/792/29/16


  • National Institutes of Health


  • Medicine(all)


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