• Shade, Robert E (PI)
  • Coelho, Anthony (PI)

    Project: Research project

    Project Details


    We will expose 18 adult male baboons to chronic psychosocial stress, diet
    induced hyperlipidemia, and diet induced elevation in bold pressure in
    order to test the hypothesis that program of graded aerobic exercise
    results in decreased extent and severity of experimentally induced
    atherosclerosis. We will examine the combined effects of stress and graded
    aerobic exercise on atherosclerosis in an animal model, where environmental
    and nutritional variables are controlled while neuroendocrine, metabolic
    and psysiologic variables are measured by means of an instrumented tether
    system. This experiment is designed to provide initial answers for two
    interrelated questions: (1) does exersise ameliorate the adverse effects
    of stress, diet and aggressive behavior on atherosclerosis, and (2) what
    are the underlying physiologic, metabolic, neuroendocrine and behavioral
    mechanisms by which exercise modfiies the effects of psychosocial stress on
    atherosclerosis. The experiment uses: (1) resistance of stable social
    organization (dyadic coalitions) to the introduction of intruders, (2)
    perturbation of a stable social dominance hierarchy by intruders as a model
    of social stress; (3) graded work on a treadmill as a model of exercise;
    (4) baboons who will be fed on atherogenic diet; and (5) an instrumented
    tether system that allows us to obtain measurement of cardiovascular and
    biochemical variables in fully conscious baboons who are unrestrained
    within the confines of their cage. The three experimental treatment groups
    consist of sedentary (n=6), light exercise (n=6) and moderate exercise
    (n=6). We will measure cardiovascular function in terms of heart rate,
    systolic, diastolic and mean blood pressure using an indwelling
    catheter/transducer; circulating mediators of cardiovascular function
    (plasma renin, electrolytes and vasopressin); hormonal indicators of
    sympathetic system arousal and stress response (plasma catecholamines,
    cortisol, and testosterone); aggressive behavior (tension, threat, attack);
    physioloigcal indicators of exercise (blood lactate, muscle papillary
    density and enzyme activity) and lipids (serum cholesterol, HDL, LDL and
    VLDL cholesterol). The animals will be autopsied and the hypotheses tested
    with respect to the effects of exercise, physiologic, metabolic and
    behavioral variables on atherogenic lesion.
    Effective start/end date9/30/859/29/95


    • National Institutes of Health: $374,329.00


    • Medicine(all)


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