EFFECTS OF PROTEOGLYCANS ON BONE RESORPTION

Project: Research project

Project Details

Description

Alveolar destruction in the periodontal diseases is strikingly localized.
The precise etiological agents responsible for this pattern of disease are
not known. Much work has centered on microbiological floras yet little
information exists to explain the disease pattern. Host factors are also
thought to be important. The specific components and the mechanisms
involved in the host response are, however, not clear. Extracellular
matrix components have been shown to have profound effects on connective
tissue cells. It is the overall objective of this proposal to enhance our
concept of the host response in periodontal disease pathogenesis. The
specific aim is to examine the role of extracellular matrix molecules in
the bone resorption process and to investigate the mechanisms by which bone
resorption occurs in the presence of these molecules. In particular, the
effect of hyaluronic acid, chondroitin sulfate A and C and dermatan sulfate
on in vitro bone resorption in the presence and absence of PTH will be
examined and compared to know effects of heparin under similar conditions.
In addition, the amount of latent collagenase, active collagenase and PGE2
released in the culture medium will be determined. The results from these
experiments will provide a basis for future experiments examining the role
of these molecules on the specific cellular components involved in bone
resorption. Furthermore, these experiments will investigate, at the
molecular level, how proteoglycans affect bone resorption and will
therefore enhance our concept of the role of the host response in the
localized alveolar destruction observed in the periodontal diseases.
StatusFinished
Effective start/end date8/1/867/31/87

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)
  • Dentistry(all)

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