DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL

Project: Research project

Project Details

Description

The research proposed is designed to provide a more quantitative
measure of the effects of opioid agonists, antagonists, and mixed
agonist-antagonists on both mu- and kappa-induced opioid
dependence in rhesus monkeys and pigeons. In monkeys, much data
has been accumulated on this issue using observations of
behavioral changes following administration of opioids in
morphine- and U-50,488- (a kappa agonist) dependent subjects.
This procedure has several drawbacks, including dependence on
trained observers, subjective reports of withdrawal signs, use of
rating scales, and the need for high morphine doses to produce
strong dependence. In the current proposal, monkeys will be
trained to discriminate the administration of naltrexone from that
of saline using a standard drug discrimination procedure.
Naltrexone will serve as an indicator of morphine withdrawal in a
group of monkeys receiving relatively low doses of morphine
chronically during training and testing of the naltrexone cue, and
will serve as an indicator of U-50,488 withdrawal in a group of
monkeys receiving chronic U-50,488 during this time. The
capacity of this procedure to produce data relevant to the
modification of withdrawal has been demonstrated well by prior
studies in pigeons. Pigeons will be trained to discriminate
naltrexone from both morphine and saline to allow parametric
evaluation of the effects of drugs on withdrawal from each of
three different morphine maintenance doses. These series of
studies should be helpful in assessing drugs for potential use in the
treatment of opioid dependence, for assisting in the classification
of currently available and newly developed opiate analgesics, as
well as having considerable interest to basic scientists in the field
of opioid pharmacology and behavioral pharmacology.
StatusFinished
Effective start/end date4/1/881/31/20

Funding

  • National Institutes of Health: $292,000.00
  • National Institutes of Health: $334,125.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $164,084.00
  • National Institutes of Health
  • National Institutes of Health: $362,400.00
  • National Institutes of Health: $292,000.00
  • National Institutes of Health: $285,138.00
  • National Institutes of Health: $53,696.00
  • National Institutes of Health: $144,658.00
  • National Institutes of Health: $182,740.00
  • National Institutes of Health: $324,101.00
  • National Institutes of Health
  • National Institutes of Health: $311,137.00
  • National Institutes of Health: $177,736.00
  • National Institutes of Health: $207,595.00
  • National Institutes of Health: $136,438.00
  • National Institutes of Health: $324,101.00
  • National Institutes of Health: $292,000.00
  • National Institutes of Health
  • National Institutes of Health: $276,869.00
  • National Institutes of Health: $118,148.00
  • National Institutes of Health: $195,929.00
  • National Institutes of Health: $324,101.00
  • National Institutes of Health
  • National Institutes of Health: $177,935.00

ASJC

  • Medicine(all)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.