• Tardif, Suzette D (PI)

Project: Research project

Project Details


The proposed research will define the causes of variability in
reproduction in marmosets and tamarins. Examination of variability
in callitrichid reproduction serves two functions. First, it is
necessary for the formulation of solutions to the problem of high
perinatal loss common in these species. Solution of this problem
is particularly important in the case of the cotton-top tamarin
(Saguinus oedipus), a species which is endangered and an important
research resource in studies of colon cancer and EB-V infection.
Previous studies have addressed the role behavior plays infant
mortality, but clearly more sophisticated, detailed information on
reproductive processes in callitrichids is now needed to fully
address the problem. Secondly, callitrichids offer unique
possibilities to examine the relation of ovulation rate, embryo
loss and neonatal mortality to environmental and physiological
factors in a primate with a relatively large and variable litter
size. The first goal of the proposed research is to determine whether
there are differences in the mechanisms controlling ovulation rats
in callitrichids with differing ovulation rare. Specifically,
endocrine correlates of ovulation rate, timing of follicular
recruitment and selection, and pituitary-ovarian feedback systems
will be examined in subjects with differing ovulation rates. The second goal is to examine the relation of nutrition and
genetics to litter size and offspring viability by monitoring
ovulation rate and embryo loss in females of known genetic
background on experimental diets. Specifically, the effects of
differences in protein and calorie intake in adult females and
calorie intake in your growing females will be determined. The third goal of the proposed research is to better define the
factors determining litter size and perinatal loss by determining
the relation of ovulation rate and embryo survival to litter size
and determining the relation of perinatal events and infant birth
condition to infant mortality.
Effective start/end date9/5/845/31/05


  • National Institutes of Health: $207,706.00
  • National Institutes of Health: $250,209.00
  • National Institutes of Health: $58,323.00
  • National Institutes of Health: $194,862.00
  • National Institutes of Health: $257,359.00


  • Medicine(all)


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