CLINICAL AND NEUROCHEMICAL SUBTYPES OF ADD

Project: Research project

Project Details

Description

This is a request for an NIMH Physician Scientist Award. The first
two years focus on providing the awardee with training and
supervison in the areas of (1) neuropsychopharmacology.
Particularly with ragard to catecholamiane function in children,
(2) the neurobiological processes associated with neurotransmitter
function, (3) the relevent laboratory methodology of High
performance-Liquid chromatography, Mass Spectrometry and enzymatic
assays, and (4) measurement of attention and impulse control in
children via standardize computer laboratory tools. In the last
three years, this knowledge will be used to carry out a researach
project under the direction of the sponsor and research advisor.
The study will compare four groups of boys diagnosed by structured
interview: (1) Attention Deficit Disorder (ADD) only, (2) ADD with
concurrent Conduct Disorder, (3) ADD with concurrent Overanxious
of the child's behavior using a standardized scoring system, and
cognitive testing will be obtained at baseline. Each subject with
ADD will then particiapte in a double-blind medication trail of two
dosage levels of methylphenidate and imipramine. The study will
examine if (1) differences in noradrenergic functioning exist
between the three subgroups of ADD and the Overanxious group, and
(2) children with ADD will respond differently to imipramine or
methylphenidate based on the presence of conduct or anxiety
symptoms.
StatusFinished
Effective start/end date9/1/888/31/94

Funding

  • National Institutes of Health: $119,481.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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