Characterization of Presynaptic Protein Nerve wracked

Project: Research projectPostdoctoral Individual National Research Service Award

Description

DESCRIPTION (provided by applicant): In this proposal I plan to investigate the
formation and function of the synaptic bouton at the Drosophila NMJ. The
control of the differentiation of the synapse presynaptically is poorly
understood. One manifestation of this differentiation is the formation of the
synaptic bouton. Synaptic boutons are found at nearly all synapses but the
formation of these varicosities as well as their function has not been
addressed experimentally. Preliminary data from the novel Drosophila gene
nerve-wracked suggests that this gene specifically controls the formation of
boutons at the NMJ. I plan to further characterize this gene and use this
reagent to investigate the formation and function of synaptic boutons.
StatusActive
Effective start/end date8/1/01 → …

Funding

  • National Institutes of Health: $40,196.00
  • National Institutes of Health: $48,148.00
  • National Institutes of Health: $44,212.00

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Presynaptic Terminals
Synapses
Drosophila
Proteins
Genes

Keywords

  • Medicine(all)
  • Neuroscience(all)