CELL GROWTH AND BONE RESORPTION IN PERIODONTAL DISEASE

Project: Research project

Project Details

Description

The cellular and molecular mechanisms involved in gingivitis and
periodontitis will be studied using a concerted biochemical,
pharmacological and cell biological approach. These are the two major
periodontal diseases and affect virtually the entire population to some
degree. Both conditions are characterized by inflammation; periodontitis
also involves bone resorption. Thus, regulation of the cellular components
of the inflammatory response and their effect on the metabolism of bone
plays a key role in periodontal disease. Accumulating data, both in vivo
and in vitro, strongly suggests that heparin plays a critical role in the
vessel wall as a regulator of smooth muscle cell growth. Heparin has also
been shown to increase the amount of bone resorbed in cultured bone
explants. The exact mechanism by which heparin functions in regulating
smooth muscle cell growth and bone resorption are not known. Based on
preliminary experiments, the effect of heparin on the synthesis of specific
proteins thought to be important in the regulation of cell growth will be
biochemically characterized and their functional significance analyzed.
The specificity and structure-function relationships of the heparin effect
on bone resorption will be determined and compared to the antiproliferative
and anticoagulant properties of heparin. The activity of antiproliferative
heparin-like species produced by endothelial cells will be examined in the
bone resorption process. Experiments are also designed to analyze the
effect of heparin on bone resorption process and include: alterations in
the synthesis of proteins, the production of factors that induce
chemotaxis, and the presence or production of molecules that specifically
interact with heparin.
StatusFinished
Effective start/end date9/1/858/31/91

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Dentistry(all)

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