• Lewis, Sharon (PI)

    Project: Research project

    Project Details


    The overall purpose of this study is to determine if there are immune
    sequelae related to the long-term donation of blood or blood products.
    Detailed studies of possible immune alterations due to donations are
    critical in determining safety for donors. The proposed study will
    investigate many aspects of the immune response which have not been
    studied in these donors to determine if any alterations occur in long-
    term donors or develop over time in new donors. The first objective of this study is to investigate changes in immune
    function which may occur as a result of blood, plasma, or platelet
    donations. Our preliminary studies have shown evidence of alterations in
    immune parameters in normal apheresis donors with the most marked
    changes occurring in long-term plasmapheresis donors. To ascertain
    whether donation of blood or blood products alters specific immune
    parameters, we will study WBC receptors known to be involved in normal
    host defense mechanisms, lymphocyte subpopulations, plasma proteins, and
    complement activation products from 30 individuals in each of 4 separate
    donor groups: whole blood donors, bulk plasma donors, plasma donors
    stimulated with incompatible RBC, and platelet donors. Donor immune data
    will be compared with results in nondonor controls will also be
    correlated with demographic data, donation history, laboratory data, and
    clinical findings. The second objective of this study is to determine if changes in an
    individual donor's immune status occur over time. A longitudinal study
    of 15 new donors in each donation group will be performed to evaluate
    alterations in immune function that may occur in committed donors of
    blood products and whether there is any clinical significance to the
    findings. New donors will be enrolled in donation groups and followed
    longitudinally for a period of up to 2 years.
    Effective start/end date2/1/921/31/97


    • National Institutes of Health: $204,419.00


    • Medicine(all)


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