BEHAVIORAL PHARMACOLOGY OF OPIOIDS

Project: Research project

Project Details

Description

This application describes a request for an ADAMHA Research Scientist
Development Award for Dr. Charles P. France. The Department of
Pharmacology at LSU Medical Center has a strong and growing research effort
in ares of drug abuse and I will use the support provided by an RSDA to
expand our overall drug abuse research program. Specifically, this request
is an attempt to provide reliable salary support for me so that I can
increase my research efforts in drug abuse, compete for additional
extramural funds to support drug abuse research in my laboratory, and
maintain an laboratory environment conducive to the training of young
researchers in the behavioral pharmacology of drug abuse. My current
formal teaching requirements as well as committee assignments will be
reduced in the event this application is awarded. The primary areas of
research supported by this application involve the use of drug
discrimination procedures to study opioid dependence and withdrawal in
nonhuman species. This research attempts to characterize important
behavioral and pharmacological features of opioid dependence as well as
identify novel compounds that might be effective in the treatment of opioid
abuse. Moreover, receptor theory will be applied extensively to
discrimination and other behavioral procedures both to test the utility of
this approach and to characterize drug affinity, selectivity and efficacy
in vivo. Other procedures that will be used in concert with drug
discrimination procedures include analgesia studies in monkeys and mice,
self-administration studies in rodents and monkeys, and studies in the
electrically-stimulated mouse vas deferens. In addition, I will continue
to pursue collaborative research on the immunologic effects of opioids in
monkeys and in mice as well as studies on the importance of metabolic
factors in the behavioral pharmacology of drugs of abuse. The RSDA will
allow me to take advantage of the expertise of my current collaborators,
particularly those with more molecular approaches. A continued and more
extensive interaction with these scientists will increase my knowledge of
various areas within pharmacology that are important to drug abuse in
general.
StatusFinished
Effective start/end date2/10/941/31/05

Funding

  • National Institutes of Health: $58,006.00
  • National Institutes of Health
  • National Institutes of Health: $122,472.00
  • National Institutes of Health
  • National Institutes of Health: $111,986.00
  • National Institutes of Health: $122,472.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $37,261.00
  • National Institutes of Health: $68,231.00
  • National Institutes of Health: $91,164.00

ASJC

  • Medicine(all)

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