Antimicrobial Coating for Biofilm Inhibition

  • Rawls, Henry R (PI)

Project: Research project

Project Details

Description

Description(provided by applicant): Candida is the third leading cause of
catheter-related nosocomial bloodstream infections. Indwelling devices have
been shown to support colonization and biofilm formulation by Candida.
Intravenous lines are the most frequent indwelling device and are the single
most common cause of candidemia. Once a Candida biofilm forms in vivo, removal
of the substrate that is supporting the biofilm growth is almost always required to eliminate the infection. Unfortunately, in many instances removal
is impossible due to deteriorated patient condition, anatomical location, or
underlying disease. The goal of this project is to incorporate an antifungal agent into unique,
patented formulations to create a coating for medical devices that is resistant
to C. albicans. A coating and antifungal delivery system that could extend the
time and/or increase the rate of delivery and achieve a higher concentration of
antifungal agents to a C. albicans-susceptible site would have enormous
therapeutic advantages over systemic and inefficacious topical routes of
delivery. To demonstrate the feasibility of this approach, the specific aims
are to optimize the coating formulation for use as short-term antifungal
coatings for medical devices, evaluate the coatings for antifungal activity in
vitro, and to perform an intramuscular implantation study in rabbits. PROPOSED COMMERCIAL APPLICATION: Candida albicans is by far the most frequently isolated human mycotic agent. The large number of immunosuppressed patients with indwelling devices combined with the extensive social and economic costs associated with treating C. albicans-related infections serve as justification for the pursuit of alternative therapies.
StatusFinished
Effective start/end date9/1/028/31/04

Funding

  • National Institutes of Health: $100,000.00

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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